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Heather A. Cooke

Observed names: H.A. Cooke, Heather A Cooke
Observed institutions: Boston College, Biogen (United States), University of Vienna, Howard Hughes Medical Institute, University of Wisconsin–Madison, University of Illinois Urbana-Champaign, Carl R. Woese Institute for Genomic Biology
ORCID: 0000-0001-9742-5993
Observed ORCID: 0000-0001-9742-5993
OpenAlex ID: A5000149019
Synthesis of Methylphosphonic Acid by Marine Microbes: A Source for Methane in the Aerobic Ocean
2012 · William W. Metcalf, Benjamin M. Griffin, et al. · Science · 315
The Mechanism of MIO-Based Aminomutases in β-Amino Acid Biosynthesis
2007 · Carl V. Christianson, Timothy J. Montavon, et al. · Journal of the American Chemical Society · 80
Structure and chemistry of 4-methylideneimidazole-5-one containing enzymes
2009 · Heather A Cooke, Carl V Christianson, et al. · Current Opinion in Chemical Biology · 57
Probing the active site of MIO‐dependent aminomutases, key catalysts in the biosynthesis of β‐amino acids incorporated in secondary metabolites
2010 · Heather A. Cooke, Steven D. Bruner · Biopolymers · 29
Molecular Basis of Substrate Promiscuity for the SAM-Dependent O-Methyltransferase NcsB1, Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin
2009 · Heather A. Cooke, Elizabeth L. Guenther, et al. · Biochemistry · 28
Mechanistic Investigation of Methylphosphonate Synthase, a Non-Heme Iron-Dependent Oxygenase
2012 · Heather A. Cooke, Spencer C. Peck, et al. · Journal of the American Chemical Society · 27
Mechanism and Substrate Recognition of 2-Hydroxyethylphosphonate Dioxygenase
2011 · Spencer C. Peck, Heather A. Cooke, et al. · Biochemistry · 26
Characterization of NcsB2 as a Promiscuous Naphthoic Acid/Coenzyme A Ligase Integral to the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin
2007 · Heather A. Cooke, Jian Zhang, et al. · Journal of the American Chemical Society · 26
Regiospecific O-Methylation of Naphthoic Acids Catalyzed by NcsB1, an O-Methyltransferase Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin
2008 · Yinggang Luo, Shuangjun Lin, et al. · Journal of Biological Chemistry · 23
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EFab domain substitution as a solution to the light-chain pairing problem of bispecific antibodies
2018 · Heather A. Cooke, Joe Arndt, et al. · mAbs · 17
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Building a potent TREM2 agonistic, biparatopic, common light chain antibody
2025 · Ana da Silva Almeida, Melissa L. Geddie, et al. · mAbs · 6
Crystal structure of Fab 7268 in complex with MBP-TREM2 Ig domain fusion
2025 · J.W. Arndt, Q. Chao, et al. · Worldwide Protein Data Bank
Crystal structure of Fabs 7411 in complex with TREM2 peptide
2025 · J.W. Arndt, Q. Chao, et al. · Worldwide Protein Data Bank
X-ray crystal structure of a tyrosine aminomutase mutant construct with bound ligand
2009 · H.A. Cooke, S.D. Bruner · Worldwide Protein Data Bank
X-ray crystal structure of tyrosine aminomutase mutant construct
2009 · H.A. Cooke, S.D. Bruner · Worldwide Protein Data Bank
Crystal structure of an O-methyltransferase (NcsB1) from neocarzinostatin biosynthesis in complex with S-adenosyl-L-homocysteine (SAH) and 1,4-dihydroxy-2-naphthoic acid (DHN)
2009 · H.A. Cooke, S.D. Bruner · Worldwide Protein Data Bank
Crystal structure of an O-methyltransferase (NcsB1) from neocarzinostatin biosynthesis in complex with S-adenosylmethionine (SAM) and 2-hydroxy-5-methyl naphthoic acid (MNA)
2009 · H.A. Cooke, S.D. Bruner · Worldwide Protein Data Bank
Crystal structure of an O-methyltransferase (NcsB1) from neocarzinostatin biosynthesis in complex with S-adenosyl-L-homocysteine (SAH)
2009 · H.A. Cooke, S.D. Bruner · Worldwide Protein Data Bank
Crystal structure of an O-methyltransferase (NcsB1) from neocarzinostatin biosynthesis in complex with S-adenosyl-L-homocysteine (SAH) and 2-hydroxy-7-methoxy-5-methyl naphthoic acid (NA)
2009 · H.A. Cooke, S.D. Bruner · Worldwide Protein Data Bank
Works count: 21
Citation count: 634
H-index: 10
I10-index: 10
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