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Timo Nuijens

Observed names: Nuijens T, Nuijens T., Nuijens, T., Nuijens, Timo, T. Nuijens
ORCID: 0000-0002-1197-2433
Observed ORCID: 0000-0002-1197-2433
OpenAlex ID: A5000612196
Enzyme-mediated ligation technologies for peptides and proteins
2017 · Marcel Schmidt, Ana Toplak, et al. · Current Opinion in Chemical Biology · 123
Peptiligase, an Enzyme for Efficient Chemoenzymatic Peptide Synthesis and Cyclization in Water
2016 · Ana Toplak, Timo Nuijens, et al. · Advanced Synthesis & Catalysis · 79
Omniligase‐1: A Powerful Tool for Peptide Head‐to‐Tail Cyclization
2017 · Marcel Schmidt, Ana Toplak, et al. · Advanced Synthesis & Catalysis · 78
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Versatile Peptide C-Terminal Functionalization via a Computationally Engineered Peptide Amidase
2016 · Bian Wu, Hein J. Wijma, et al. · ACS Catalysis · 72
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Sustainable, cost-efficient manufacturing of therapeutic peptides using chemo-enzymatic peptide synthesis (CEPS)
2019 · Jan Pawlas, Timo Nuijens, et al. · Green Chemistry · 70
Natural Occurring and Engineered Enzymes for Peptide Ligation and Cyclization
2019 · Timo Nuijens, Ana Toplak, et al. · Frontiers in Chemistry · 66
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Engineering a Diverse Ligase Toolbox for Peptide Segment Condensation
2016 · Timo Nuijens, Ana Toplak, et al. · Advanced Synthesis & Catalysis · 53
Enzyme-catalyzed peptide cyclization
2017 · Marcel Schmidt, Ana Toplak, et al. · Drug Discovery Today Technologies · 52
Enzymatic Synthesis ofC-Terminal Arylamides of Amino Acids and Peptides
2009 · Timo Nuijens, Claudia Cusan, et al. · The Journal of Organic Chemistry · 40
Design of a substrate-tailored peptiligase variant for the efficient synthesis of thymosin-α 1
2018 · Marcel Schmidt, Ana Toplak, et al. · Organic & Biomolecular Chemistry · 37
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Efficient Enzymatic Cyclization of Disulfide‐Rich Peptides by Using Peptide Ligases
2019 · Marcel Schmidt, Yen‐Hua Huang, et al. · ChemBioChem · 35
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Enzymatic synthesis of activated esters and their subsequent use in enzyme-based peptide synthesis
2011 · Timo Nuijens, Claudia Cusan, et al. · Journal of Molecular Catalysis B Enzymatic · 34
From thiol-subtilisin to omniligase: Design and structure of a broadly applicable peptide ligase
2021 · Ana Toplak, Eduardo F. Teixeira de Oliveira, et al. · Computational and Structural Biotechnology Journal · 32
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Synthesis of Constrained Tetracyclic Peptides by Consecutive CEPS, CLIPS, and Oxime Ligation
2019 · Dieuwertje E. Streefkerk, Marcel Schmidt, et al. · Organic Letters · 31
Racemization‐Free Chemoenzymatic Peptide Synthesis Enabled by the Ruthenium‐Catalyzed Synthesis of Peptide Enol Esters via Alkyne‐Addition and Subsequent Conversion Using Alcalase‐Cross‐Linked Enzyme Aggregates
2013 · Hilmar Schröder, Gernot A. Strohmeier, et al. · Advanced Synthesis & Catalysis · 31
Fully Enzymatic Peptide Synthesis using C‐Terminal tert‐Butyl Ester Interconversion
2010 · Timo Nuijens, Claudia Cusan, et al. · Advanced Synthesis & Catalysis · 27
Improved solid phase synthesis of peptide carboxyamidomethyl (Cam) esters for enzymatic segment condensation
2016 · Timo Nuijens, Ana Toplak, et al. · Tetrahedron Letters · 25
Enzymatic C-terminal amidation of amino acids and peptides
2012 · Timo Nuijens, Elena Piva, et al. · Tetrahedron Letters · 23
Traceless enzymatic protein synthesis without ligation sites constraint
2021 · Ruifeng Li, Marcel Schmidt, et al. · National Science Review · 21
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Peptide synthesis in neat organic solvents with novel thermostable proteases
2015 · Ana Toplak, Timo Nuijens, et al. · Enzyme and Microbial Technology · 21
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A One‐Pot “Triple‐C” Multicyclization Methodology for the Synthesis of Highly Constrained Isomerically Pure Tetracyclic Peptides
2018 · Gaston J. J. Richelle, Marcel Schmidt, et al. · ChemBioChem · 20
Fully Enzymatic N→C‐Directed Peptide Synthesis Using C‐Terminal Peptide α‐Carboxamide to Ester Interconversion
2011 · Timo Nuijens, Elena Piva, et al. · Advanced Synthesis & Catalysis · 18
Selecting optimal conditions for Alcalase CLEA-OM for synthesis of dipeptides in organic media
2011 · P. Vossenberg, H.H. Beeftink, et al. · Journal of Molecular Catalysis B Enzymatic · 17
Papain‐Catalyzed Peptide Bond Formation: Enzyme‐Specific Activation with Guanidinophenyl Esters
2011 · Roseri J. A. C. de Beer, Barbara Zarzycka, et al. · ChemBioChem · 17
A versatile and selective chemo-enzymatic synthesis of β-protected aspartic and γ-protected glutamic acid derivatives
2009 · Timo Nuijens, John A.W. Kruijtzer, et al. · Tetrahedron Letters · 17
Works count: 50
Citation count: 1,159
H-index: 20
I10-index: 32
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