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Hadas Reuveni

Therapeutic Destruction of Insulin Receptor Substrates for Cancer Treatment
2013 · Hadas Reuveni, Efrat Flashner-Abramson, et al. · Cancer Research · 125
LynIs a Target Gene for Prostate Cancer
2004 · Mirela Goldenberg-Furmanov, Ilan Stein, et al. · Cancer Research · 111
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Toward a PKB Inhibitor: Modification of a Selective PKA Inhibitor by Rational Design
2002 · Hadas Reuveni, Nurit Livnah, et al. · Biochemistry · 104
Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3)
2003 · Tamar Licht, Lilia Tsirulnikov, et al. · Blood · 97
Signal transduction by a nondissociable heterotrimeric yeast G protein
2000 · Shoshana Klein, Hadas Reuveni, et al. · Proceedings of the National Academy of Sciences · 90
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S1PR3 Signaling Drives Bacterial Killing and Is Required for Survival in Bacterial Sepsis
2017 · JinChao Hou, QiXing Chen, et al. · American Journal of Respiratory and Critical Care Medicine · 70
A novel inhibitor of the insulin/IGF signaling pathway protects from age‐onset, neurodegeneration‐linked proteotoxicity
2013 · Tayir El‐Ami, Lorna Moll, et al. · Aging Cell · 69
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Antidiabetic effect of novel modulating peptides of G-protein-coupled kinase in experimental models of diabetes
2004 · Y. Anis, O. Leshem, et al. · Diabetologia · 52
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The Tyrphostin NT157 Suppresses Insulin Receptor Substrates and Augments Therapeutic Response of Prostate Cancer
2014 · Naokazu Ibuki, Mazyar Ghaffari, et al. · Molecular Cancer Therapeutics · 48
Sequence-based Design of Kinase Inhibitors Applicable for Therapeutics and Target Identification
2004 · Masha Y. Niv, Hila Rubin, et al. · Journal of Biological Chemistry · 46
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Targeting melanoma with NT157 by blocking Stat3 and IGF1R signaling
2015 · E Flashner-Abramson, S Klein, et al. · Oncogene · 44
Prevention of insulin resistance and beta‐cell loss by abrogating PKCε‐induced serine phosphorylation of muscle IRS‐1 in Psammomys obesus
2008 · Esther Mack, Ehud Ziv, et al. · Diabetes/Metabolism Research and Reviews · 36
The inhibition of IGF‐1 signaling promotes proteostasis by enhancing protein aggregation and deposition
2015 · Lorna Moll, Tziona Ben‐Gedalya, et al. · The FASEB Journal · 29
Synthesis of a Novel Macrocyclic Library: Discovery of an IGF-1R Inhibitor
2008 · Nir Qvit, Hadas Reuveni, et al. · Journal of Combinatorial Chemistry · 29
Reversal of the Ras-Induced Transformed Phenotype by Hr12, a Novel Ras Farnesylation Inhibitor, Is Mediated by the Mek/ERK Pathway
2000 · Hadas Reuveni, Tamar Geiger, et al. · The Journal of Cell Biology · 27
405 The tyrphostin, NT157, suppresses insulin receptor substrates and augments therapeutic response of prostate cancer
2015 · I. Naokazu, G. Mazyar, et al. · European Urology Supplements · 25
IRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy
2021 · Adi Jacob Berger, Elinor Gigi, et al. · Nature Cancer · 20
α-Cyanocinnamide derivatives: a new family of non-peptide, non-sulfhydryl inhibitors of ras farnesylation
1999 · Enrique Poradosu, Aviv Gazit, et al. · Bioorganic & Medicinal Chemistry · 14
Synthesis and biological activity of semipeptoid farnesyltransferase inhibitors
1997 · Hadas Reuveni, Alex Gitler, et al. · Bioorganic & Medicinal Chemistry · 14
The inhibition of Ras farnesylation leads to an increase in p27Kip1 and G1 cell cycle arrest
2003 · Hadas Reuveni, Shoshana Klein, et al. · European Journal of Biochemistry · 8
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Sequence-Based Protein Kinase Inhibition: Applications for Drug Development
2005 · Isaiah D. Wexler, Masha Y. Niv, et al. · BioTechniques · 7
IRS2 as a driver of brain metastasis in colorectal cancer: A potential target for novel therapeutic strategies
2025 · Inbal Greenberg, Fayhaa Khair-Dabour, et al. · Neuro-Oncology · 4
Abstract 5181: Early activity and biomarker evaluation of NT219 in combination with cetuximab in a Phase 1/2 study of recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN)
2024 · Ari J. Rosenberg, Shumei Kato, et al. · Cancer Research · 2
Abstract 1939: NT219, a dual inhibitor of IRS1/2 and STAT3, suppresses cancer stem cell mediated resistance to KRASG12C and KRASG12D inhibitors in solid tumors
2024 · Hadas Reuveni, Mohammed Najeeb Al-Hallak, et al. · Cancer Research · 2
Genomic alterations drive brain metastases formation in colorectal cancer: The role of IRS2
2022 · Inbal Greenberg, Ethan Sokol, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
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Works count: 67
Citation count: 1,081
H-index: 17
I10-index: 19
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