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Nick Loizos

Targeting the platelet-derived growth factor receptor α with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts: Implications as a potential therapeutic target
2005 · Nick Loizos, Yan Xu, et al. · Molecular Cancer Therapeutics · 118
Platelet-derived growth factor receptor-α: a novel therapeutic target in human hepatocellular cancer
2007 · Peggy Stock, Dulabh Monga, et al. · Molecular Cancer Therapeutics · 108
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Lack of detection of agonist activity by antibodies to platelet‐derived growth factor receptor α in a subset of normal and systemic sclerosis patient sera
2009 · Nick Loizos, Leah LaRiccia, et al. · Arthritis & Rheumatism · 80
Correction to: The td intron endonuclease I‐TevI makes extensive sequence‐tolerant contacts across the minor groove of its DNA target.
1993 · M. Bryk, S.M. Quirk, et al. · The EMBO Journal · 75
Evolution of mobile group I introns: recognition of intron sequences by an intron-encoded endonuclease.
1994 · N Loizos, E R Tillier, et al. · Proceedings of the National Academy of Sciences · 66
Development of a Fully Human Anti-PDGFRβ Antibody That Suppresses Growth of Human Tumor Xenografts and Enhances Antitumor Activity of an Anti-VEGFR2 Antibody
2009 · Juqun Shen, Marie Danielle Vil, et al. · Neoplasia · 63
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Rationale for the development of IMC‐3G3, a fully human immunoglobulin G subclass 1 monoclonal antibody targeting the platelet‐derived growth factor receptor α
2010 · Gaurav D. Shah, Nick Loizos, et al. · Cancer · 62
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A phase I study of olaratumab, an anti-platelet-derived growth factor receptor alpha (PDGFRα) monoclonal antibody, in patients with advanced solid tumors
2014 · E. Gabriela Chiorean, Christopher Sweeney, et al. · Cancer Chemotherapy and Pharmacology · 61
Platelet-Derived Growth Factor Receptor α Contributes to Human Hepatic Stellate Cell Proliferation and Migration
2017 · Alexander Kikuchi, Tirthadipa Pradhan-Sundd, et al. · American Journal Of Pathology · 53
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4 Homing Endonucleases
1993 · John Mueller, Mary Bryk, et al. · Cold Spring Harbor Monograph Archive · 50
The td intron endonuclease I‐TevI makes extensive sequence‐tolerant contacts across the minor groove of its DNA target.
1993 · M. Bryk, S.M. Quirk, et al. · The EMBO Journal · 47
Stromal Platelet-Derived Growth Factor Receptor α (PDGFRα) Provides a Therapeutic Target Independent of Tumor Cell PDGFRα Expression in Lung Cancer Xenografts
2012 · David E. Gerber, Puja Gupta, et al. · Molecular Cancer Therapeutics · 42
An antibody directed against PDGF receptor β enhances the antitumor and the anti-angiogenic activities of an anti-VEGF receptor 2 antibody
2007 · Juqun Shen, Marie D. Vil, et al. · Biochemical and Biophysical Research Communications · 40
Human Bone Marrow Activates the Akt Pathway in Metastatic Prostate Cells through Transactivation of the α-Platelet–Derived Growth Factor Receptor
2007 · Nathan G. Dolloff, Mike R. Russell, et al. · Cancer Research · 39
Platelet-derived growth factor receptor alpha (PDGFRα) targeting and relevant biomarkers in ovarian carcinoma
2013 · Koji Matsuo, Masato Nishimura, et al. · Gynecologic Oncology · 38
Olaratumab Exerts Antitumor Activity in Preclinical Models of Pediatric Bone and Soft Tissue Tumors through Inhibition of Platelet-Derived Growth Factor Receptor α
2017 · Caitlin D. Lowery, Wayne Blosser, et al. · Clinical Cancer Research · 34
Determinants for Escherichia coli RNA polymerase assembly within the β subunit
1997 · Yi Wang, Konstantin Severinov, et al. · Journal of Molecular Biology · 34
Intron-encoded Endonuclease I-TevII Binds Across the Minor Groove and Induces Two Distinct Conformational Changes in its DNA Substrate
1996 · Nick Loizos, George H. Silva, et al. · Journal of Molecular Biology · 33
Mapping Interactions of Escherichia coli GreB with RNA Polymerase and Ternary Elongation Complexes
1999 · Nick Loizos, Seth A. Darst · Journal of Biological Chemistry · 29
Phase 1 study of narnatumab, an anti-RON receptor monoclonal antibody, in patients with advanced solid tumors
2017 · Patricia M. LoRusso, Mrinal Gounder, et al. · Investigational New Drugs · 22
Inhibition of fibroblast growth factor receptor 3-dependent lung adenocarcinoma with a human monoclonal antibody
2016 · Yongjun Yin, Xiaodi Ren, et al. · Disease Models & Mechanisms · 19
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A human monoclonal antibody targeting the stem cell factor receptor (c-Kit) blocks tumor cell signaling and inhibits tumor growth
2014 · Maria B Lebron, Laura Brennan, et al. · Cancer Biology & Therapy · 12
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Mapping Protein–Ligand Interactions by Hydroxyl-Radical Protein Footprinting
2004 · Nick Loizos · Humana Press eBooks · 11
Mapping protein–ligand interactions by footprinting, a radical idea
1998 · Nick Loizos, Seth A Darst · Structure · 9
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Randomized phase II trial of pegylated liposomal doxorubicin (PLD) with or without anti-platelet-derived growth factor receptor-alpha (PDGFR-alpha) monoclonal antibody IMC-3G3 in platinum-refractory/resistant advanced ovarian cancer.
2010 · W. P. McGuire, G. D. Shah, et al. · Journal of Clinical Oncology · 7
Works count: 57
Citation count: 1,163
H-index: 20
I10-index: 23
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