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Hideyuki Oki

Observed names: H. Oki, Oki, Hideyuki
ORCID: 0000-0003-1927-053X
Observed ORCID: 0000-0003-1927-053X
OpenAlex ID: A5001043320
Crystal structure of methionine aminopeptidase from hyperthermophile, Pyrococcus furiosus
1998 · Tahir H Tahirov, Hideyuki Oki, et al. · Journal of Molecular Biology · 146
Cryo-EM Structure of K+-Bound hERG Channel Complexed with the Blocker Astemizole
2021 · Tatsuki Asai, Naruhiko Adachi, et al. · Structure · 99
Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor
2013 · Naoki Miyamoto, Nozomu Sakai, et al. · Bioorganic & Medicinal Chemistry · 77
Design and Synthesis of Novel DFG-Out RAF/Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Inhibitors. 1. Exploration of [5,6]-Fused Bicyclic Scaffolds
2012 · Masanori Okaniwa, Masaaki Hirose, et al. · Journal of Medicinal Chemistry · 75
Discovery of 1-[2-Fluoro-4-(1 H -pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1 H -pyrazol-5-yl)pyridazin-4(1 H )-one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor
2014 · Jun Kunitomo, Masato Yoshikawa, et al. · Journal of Medicinal Chemistry · 64
Discovery of Novel, Highly Potent, and Selective Quinazoline-2-carboxamide-Based Matrix Metalloproteinase (MMP)-13 Inhibitors without a Zinc Binding Group Using a Structure-Based Design Approach
2014 · Hiroshi Nara, Kenjiro Sato, et al. · Journal of Medicinal Chemistry · 64
Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach
2016 · Hiroshi Nara, Akira Kaieda, et al. · Journal of Medicinal Chemistry · 63
Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors
2013 · Shigemitsu Matsumoto, Naoki Miyamoto, et al. · Bioorganic & Medicinal Chemistry · 60
Discovery of a B-Cell Lymphoma 6 Protein–Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach
2017 · Yusuke Kamada, Nozomu Sakai, et al. · Journal of Medicinal Chemistry · 57
Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: Highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site
2014 · Hiroshi Nara, Kenjiro Sato, et al. · Bioorganic & Medicinal Chemistry · 55
Refined structure of orthorhombic lysozyme crystallized at high temperature: correlation between morphology and intermolecular contacts
1999 · Hideyuki Oki, Yoshiki Matsuura, et al. · Acta Crystallographica Section D Biological Crystallography · 55
T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice
2018 · Satoru Matsuda, Rina Baba, et al. · Neuropsychopharmacology · 53
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LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models
2021 · Rina Baba, Satoru Matsuda, et al. · Science Advances · 47
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Synthesis and Structure Activity Relationship Studies of Benzothieno[3,2-b]furan Derivatives as a Novel Class of IKK.BETA. Inhibitors
2007 · Hideyuki Sugiyama, Masato Yoshida, et al. · Chemical and Pharmaceutical Bulletin · 47
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Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders
2017 · Satoshi Mikami, Shigekazu Sasaki, et al. · Journal of Medicinal Chemistry · 45
Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay
2017 · Misa Iwatani-Yoshihara, Masahiro Ito, et al. · ACS Chemical Biology · 41
Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors
2016 · Hiroshi Nara, Kenjiro Sato, et al. · Bioorganic & Medicinal Chemistry · 37
Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors
2012 · Mitsunori Kono, Takahiro Matsumoto, et al. · Bioorganic & Medicinal Chemistry · 37
Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders
2017 · Satoshi Mikami, Shinji Nakamura, et al. · Journal of Medicinal Chemistry · 36
Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor
2015 · Masato Yoshikawa, Haruhi Kamisaki, et al. · Bioorganic & Medicinal Chemistry · 34
A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases
2012 · Hidehisa Iwata, Hideyuki Oki, et al. · ACS Medicinal Chemistry Letters · 31
Design, synthesis, and structure–activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects
2022 · Yasushi Hattori, Shigemitsu Matsumoto, et al. · European Journal of Medicinal Chemistry · 30
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BTZO-1, a Cardioprotective Agent, Reveals that Macrophage Migration Inhibitory Factor Regulates ARE-Mediated Gene Expression
2010 · Haruhide Kimura, Yoshimi Sato, et al. · Chemistry & Biology · 30
High-Resolution Crystals of Methionine Aminopeptidase fromPyrococcus furiosusObtained by Water-Mediated Transformation
1998 · Tahir H Tahirov, Hideyuki Oki, et al. · Journal of Structural Biology · 23
A new brain‐penetrant glucosylceramide synthase inhibitor as potential Therapeutics for Gaucher disease
2021 · Takahiro Fujii, Yuta Tanaka, et al. · Journal of Neurochemistry · 21
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Works count: 45
Citation count: 1,394
H-index: 23
I10-index: 28
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