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Roberto A. Chica

Observed names: Chica, R, Chica, R., Chica, R. A., Chica, Roberto, Chica, Roberto A, Chica, Roberto A., Chica, Roberto Antonio, R.A. Chica, Roberto A Chica, Roberto A. Chica
Observed institutions: California Institute of Technology, University of Ottawa, PROTEO, Université Laval, Centre for Catalysis Research and Innovation, Université de Montréal
ORCID: 0000-0003-3789-9841
Observed ORCID: 0000-0003-3789-9841
OpenAlex ID: A5001218668
Semi-rational approaches to engineering enzyme activity: combining the benefits of directed evolution and rational design
2005 · Roberto A Chica, Nicolas Doucet, et al. · Current Opinion in Biotechnology · 449
Iterative approach to computational enzyme design
2012 · Heidi K. Privett, Gert Kiss, et al. · Proceedings of the National Academy of Sciences · 334
Protein Engineering, Design and Selection
2020 · Roberto A Chica · Protein Engineering Design and Selection · 142
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Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico
2020 · Aron Broom, Rojo V. Rakotoharisoa, et al. · Nature Communications · 121
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Generation of longer emission wavelength red fluorescent proteins using computationally designed libraries
2010 · Roberto A. Chica, Matthew M. Moore, et al. · Proceedings of the National Academy of Sciences · 96
Rational design of proteins that exchange on functional timescales
2017 · James A Davey, Adam M Damry, et al. · Nature Chemical Biology · 86
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Multistate approaches in computational protein design
2012 · James A. Davey, Roberto A. Chica · Protein Science · 77
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One-Pot Biocatalytic Synthesis of Substituted d -Tryptophans from Indoles Enabled by an Engineered Aminotransferase
2019 · Fabio Parmeggiani, Arnau Rué Casamajo, et al. · ACS Catalysis · 64
ProtaBank: A repository for protein design and engineering data
2018 · Connie Y. Wang, Paul M. Chang, et al. · Protein Science · 61
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The bioorganic chemistry of transglutaminase — from mechanism to inhibition and engineering
2008 · Jeffrey W Keillor, Roberto A Chica, et al. · Canadian Journal of Chemistry · 46
Improving the accuracy of protein stability predictions with multistate design using a variety of backbone ensembles
2013 · James A. Davey, Roberto A. Chica · Proteins Structure Function and Bioinformatics · 45
Computational remodeling of an enzyme conformational landscape for altered substrate selectivity
2023 · Antony D. St-Jacques, Joshua M. Rodriguez, et al. · Nature Communications · 44
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Tissue transglutaminase acylation: Proposed role of conserved active site Tyr and Trp residues revealed by molecular modeling of peptide substrate binding
2004 · Roberto A. Chica, Paul Gagnon, et al. · Protein Science · 42
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Discovery of Substrates for a SET Domain Lysine Methyltransferase Predicted by Multistate Computational Protein Design
2014 · Sylvain Lanouette, James A. Davey, et al. · Structure · 41
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Computational Design of Multisubstrate Enzyme Specificity
2019 · Antony D. St-Jacques, Marie-Ève C. Eyahpaise, et al. · ACS Catalysis · 36
Distal mutations enhance catalysis in designed enzymes by facilitating substrate binding and product release
2025 · Niayesh Zarifi, Pooja Asthana, et al. · Nature Communications · 35
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Engineered Aminotransferase for the Production of d ‐Phenylalanine Derivatives Using Biocatalytic Cascades
2017 · Curtis J. W. Walton, Fabio Parmeggiani, et al. · ChemCatChem · 32
Biocatalytic retrosynthesis approaches to d -(2,4,5-trifluorophenyl)alanine, key precursor of the antidiabetic sitagliptin
2019 · Fabio Parmeggiani, Arnau Rué Casamajo, et al. · Green Chemistry · 30
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Structure-guided rational design of red fluorescent proteins: towards designer genetically-encoded fluorophores
2016 · Matthew G Eason, Adam M Damry, et al. · Current Opinion in Structural Biology · 25
Expression and rapid purification of highly active hexahistidine-tagged guinea pig liver transglutaminase
2003 · Steve M.F.G. Gillet, Roberto A. Chica, et al. · Protein Expression and Purification · 25
Recovery of Red Fluorescent Protein Chromophore Maturation Deficiency through Rational Design
2012 · Matthew M. Moore, Samuel K. Oteng-Pabi, et al. · PLoS ONE · 24
Prediction of Stable Globular Proteins Using Negative Design with Non-native Backbone Ensembles
2015 · James A. Davey, Adam M. Damry, et al. · Structure · 23
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Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme
2011 · Andrew C. Hemmert, Tamara C. Otto, et al. · PLoS ONE · 23
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Brighter Red Fluorescent Proteins by Rational Design of Triple-Decker Motif
2015 · Antonia T. Pandelieva, Miranda J. Baran, et al. · ACS Chemical Biology · 22
Photolabeling of Tissue Transglutaminase Reveals the Binding Mode of Potent Cinnamoyl Inhibitors
2009 · Christophe Pardin, Isabelle Roy, et al. · Biochemistry · 22
Works count: 119
Citation count: 2,172
H-index: 23
I10-index: 35
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