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Christian M. Simon

Observed names: Christian M Simon, Christian Simon, Christian M. Simon, Simon, Christian M.
Institution: Leipzig University
ORCID: 0000-0002-3996-4697
Observed ORCID: 0000-0002-3996-4697
OpenAlex ID: A5001955404
Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy
2017 · Emily V Fletcher, Christian M Simon, et al. · Nature Neuroscience · 140
Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA
2021 · Lingling Kong, David O. Valdivia, et al. · Science Translational Medicine · 127
Converging Mechanisms of p53 Activation Drive Motor Neuron Degeneration in Spinal Muscular Atrophy
2017 · Christian M. Simon, Ya Dai, et al. · Cell Reports · 106
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Presynaptic Localization of Smn and hnRNP R in Axon Terminals of Embryonic and Postnatal Mouse Motoneurons
2014 · Benjamin Dombert, Rajeeve Sivadasan, et al. · PLoS ONE · 71
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Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy
2018 · Meaghan Van Alstyne, Christian M. Simon, et al. · Genes & Development · 70
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Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy
2019 · Christian M. Simon, Meaghan Van Alstyne, et al. · Cell Reports · 63
Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of mild spinal muscular atrophy
2009 · Christian M. Simon, Sibylle Jablonka, et al. · Human Molecular Genetics · 63
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Activity Regulates the Incidence of Heteronymous Sensory-Motor Connections
2015 · Alana I. Mendelsohn, Christian M. Simon, et al. · Neuron · 58
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Central synaptopathy is the most conserved feature of motor circuit pathology across spinal muscular atrophy mouse models
2021 · Jannik M. Buettner, Josiane K. Sime Longang, et al. · iScience · 44
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A Stem Cell Model of the Motor Circuit Uncouples Motor Neuron Death from Hyperexcitability Induced by SMN Deficiency
2016 · Christian M. Simon, Anna M. Janas, et al. · Cell Reports · 42
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Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy
2015 · Christian M. Simon, Stefanie Rauskolb, et al. · Acta Neuropathologica · 42
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The PDZ-Domain Protein Whirlin Facilitates Mechanosensory Signaling in Mammalian Proprioceptors
2015 · Joriene C. de Nooij, Christian M. Simon, et al. · Journal of Neuroscience · 33
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SMN controls neuromuscular junction integrity through U7 snRNP
2022 · Sarah Tisdale, Meaghan Van Alstyne, et al. · Cell Reports · 31
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Chronic Pharmacological Increase of Neuronal Activity Improves Sensory-Motor Dysfunction in Spinal Muscular Atrophy Mice
2020 · Christian M. Simon, Beatriz Blanco-Redondo, et al. · Journal of Neuroscience · 24
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Peripherally-derived LGI1-reactive monoclonal antibodies cause epileptic seizures in vivo
2024 · Manoj Upadhya, Toni Kirmann, et al. · Brain · 22
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Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy
2023 · Luisa Hennlein, Hanaa Ghanawi, et al. · The Journal of Cell Biology · 22
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P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons
2009 · Matthias Fischer, Patricia Marques Pereira, et al. · Molecular and Cellular Neuroscience · 19
Proprioceptive synaptic dysfunction is a key feature in mice and humans with spinal muscular atrophy
2025 · Christian M Simon, Nicolas Delestrée, et al. · Brain · 17
The systemic complexity of a monogenic disease: the molecular network of spinal muscular atrophy
2024 · Ines Tapken, Theresa Schweitzer, et al. · Brain · 13
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Boosting neuregulin 1 type-III expression hastens SMA motor axon maturation
2023 · Lingling Kong, Cera W. Hassinan, et al. · Acta Neuropathologica Communications · 12
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Catecholaminergic dysfunction drives postural and locomotor deficits in a mouse model of spinal muscular atrophy
2025 · John G. Pagiazitis, Nicolas Delestrée, et al. · Cell Reports · 10
Laser microscopy acquisition and analysis of premotor synapses in the murine spinal cord
2022 · Jannik M. Buettner, Toni Kirmann, et al. · STAR Protocols · 10
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p53-dependent c-Fos expression is a marker but not executor for motor neuron death in spinal muscular atrophy mouse models
2022 · Jannik M. Buettner, Leonie Sowoidnich, et al. · Frontiers in Cellular Neuroscience · 8
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Cerebellar pathology contributes to neurodevelopmental deficits in spinal muscular atrophy
2025 · Florian Gerstner, Sandra Wittig, et al. · Brain · 7
A standardized framework resolves ambiguity in motor neuron loss across neurodegenerative diseases
2026 · Leonie Sowoidnich, Aaron L. Norman, et al. · Acta Neuropathologica Communications · 1
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Works count: 35
Citation count: 1,054
H-index: 17
I10-index: 22
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