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Takashi Yoshikado

Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers
2018 · Issey Takehara, Takashi Yoshikado, et al. · Pharmaceutical Research · 93
Quantitative Analyses of Hepatic OATP‐Mediated Interactions Between Statins and Inhibitors Using PBPK Modeling With a Parameter Optimization Method
2016 · T Yoshikado, K Yoshida, et al. · Clinical Pharmacology & Therapeutics · 93
Itraconazole-Induced Cholestasis: Involvement of the Inhibition of Bile Canalicular Phospholipid Translocator MDR3/ABCB4
2010 · Takashi Yoshikado, Tappei Takada, et al. · Molecular Pharmacology · 84
PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3
2018 · Takashi Yoshikado, Kota Toshimoto, et al. · CPT Pharmacometrics & Systems Pharmacology · 80
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Investigation of Glycochenodeoxycholate Sulfate and Chenodeoxycholate Glucuronide as Surrogate Endogenous Probes for Drug Interaction Studies of OATP1B1 and OATP1B3 in Healthy Japanese Volunteers
2017 · Issey Takehara, Hanano Terashima, et al. · Pharmaceutical Research · 73
Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers
2018 · Daiki Mori, Yushi Kashihara, et al. · Drug Metabolism and Pharmacokinetics · 68
Small-Dosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1 and ABCG2), and Interaction (Atorvastatin and Grapefruit Juice) Profiles of 5 Probes for OATP2B1 and BCRP
2017 · Yushi Kashihara, Ichiro Ieiri, et al. · Journal of Pharmaceutical Sciences · 55
Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins
2017 · Takashi Yoshikado, Kota Toshimoto, et al. · Drug Metabolism and Disposition · 54
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NPC2 Regulates Biliary Cholesterol Secretion via Stimulation of ABCG5/G8-Mediated Cholesterol Transport
2011 · Yoshihide Yamanashi, Tappei Takada, et al. · Gastroenterology · 53
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Clarification of the Mechanism of Clopidogrel-Mediated Drug–Drug Interaction in a Clinical Cassette Small-dose Study and Its Prediction Based on In Vitro Information
2016 · Soo-Jin Kim, Takashi Yoshikado, et al. · Drug Metabolism and Disposition · 50
Receptor for activated C‐kinase 1 regulates the cellular localization and function of ABCB4
2009 · Yuki Ikebuchi, Tappei Takada, et al. · Hepatology Research · 39
A Clinical Cassette Dosing Study for Evaluating the Contribution of Hepatic OATPs and CYP3A to Drug-Drug Interactions
2017 · Takashi Yoshikado, Kazuya Maeda, et al. · Pharmaceutical Research · 37
Physiologically‐based pharmacokinetic model‐based translation of OATP1B ‐mediated drug–drug interactions from coproporphyrin I to probe drugs
2022 · Tatsuki Mochizuki, Yasunori Aoki, et al. · Clinical and Translational Science · 35
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Physiologically Based Pharmacokinetic Modeling of Bosentan Identifies the Saturable Hepatic Uptake As a Major Contributor to Its Nonlinear Pharmacokinetics
2018 · Masanobu Sato, Kota Toshimoto, et al. · Drug Metabolism and Disposition · 24
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Cluster Gauss‐Newton method analyses of PBPK model parameter combinations of coproporphyrin‐I based on OATP1B ‐mediated rifampicin interaction studies
2022 · Takashi Yoshikado, Yasunori Aoki, et al. · CPT Pharmacometrics & Systems Pharmacology · 23
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Quantitative Analysis of Complex Drug-Drug Interactions between Cerivastatin and Metabolism/Transport Inhibitors Using Physiologically Based Pharmacokinetic Modeling
2018 · Yoshiaki Yao, Kota Toshimoto, et al. · Drug Metabolism and Disposition · 22
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Quantitative Analysis of Complex Drug–Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data
2017 · Soo-Jin Kim, Kota Toshimoto, et al. · Journal of Pharmaceutical Sciences · 22
Ticlopidine, a Cholestatic Liver Injury-Inducible Drug, Causes Dysfunction of Bile Formation via Diminished Biliary Secretion of Phospholipids: Involvement of Biliary-Excreted Glutathione-Conjugated Ticlopidine Metabolites
2012 · Takashi Yoshikado, Tappei Takada, et al. · Molecular Pharmacology · 19
Evaluation of Hepatic Uptake of OATP1B Substrates by Short Term-Cultured Plated Human Hepatocytes: Comparison With Isolated Suspended Hepatocytes
2020 · Takashi Yoshikado, Wooin Lee, et al. · Journal of Pharmaceutical Sciences · 18
Quantitative Analyses of the Influence of Parameters Governing Rate-Determining Process of Hepatic Elimination of Drugs on the Magnitudes of Drug-Drug Interactions via Hepatic OATPs and CYP3A Using Physiologically Based Pharmacokinetic Models
2017 · Takashi Yoshikado, Kazuya Maeda, et al. · Journal of Pharmaceutical Sciences · 17
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Synthesis of benzofurazan derivatization reagents for short chain carboxylic acids in liquid chromatography/electrospray ionization‐tandem mass spectrometry (LC/ESI‐MS/MS)
2008 · Tomofumi Santa, Osama Y. Al‐Dirbashi, et al. · Biomedical Chromatography · 17
Total hepatocellular disposition profiling of rosuvastatin and pitavastatin in sandwich-cultured human hepatocytes
2018 · Katsuhiro Kanda, Ryosuke Takahashi, et al. · Drug Metabolism and Pharmacokinetics · 16
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Evaluation of Alteration in Hepatic and Intestinal BCRP Function In Vivo from ABCG2 c.421C>A Polymorphism Based on PBPK Analysis of Rosuvastatin
2018 · Azusa Futatsugi, Kota Toshimoto, et al. · Drug Metabolism and Disposition · 16
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Ursodeoxycholic acid stimulates the formation of the bile canalicular network
2012 · Yuki Ikebuchi, Hidetoshi Shimizu, et al. · Biochemical Pharmacology · 12
Elucidating Contributions of Drug Transporters/Enzyme to Nonlinear Pharmacokinetics of Grazoprevir by PBPK Modeling With a Cluster Gauss–Newton Method
2025 · Takashi Yoshikado, Yasunori Aoki, et al. · CPT Pharmacometrics & Systems Pharmacology · 5
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Works count: 41
Citation count: 1,036
H-index: 18
I10-index: 24
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