Author

Andreas Mühlemann

Observed names: A Mühlemann, Andreas Mühlemann, MÃ¼hlemann, Andreas, Mühlemann, Andreas

Institutions: Idorsia (Switzerland), Idorsia Pharmaceuticals Ltd (Switzerland)

Observed institutions: University of Geneva, F. Hoffmann-La Roche AG, Idorsia (Switzerland), CNS Research (United States), Idorsia Pharmaceuticals Ltd (Switzerland), Actelion (Switzerland)

ORCID: 0009-0001-3914-1535

Observed ORCID: 0009-0001-3914-1535

OpenAlex ID: A5003242135

Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

2005 · Richard H.P. Porter, Georg Jaeschke, et al. · Journal of Pharmacology and Experimental Therapeutics · 312

Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP

2006 · Pari Malherbe, Nicole Kratochwil, et al. · Journal of Neurochemistry · 68

An Automated System for the Analysis of G Protein-Coupled Receptor Transmembrane Binding Pockets: Alignment, Receptor-Based Pharmacophores, and Their Application

2005 · Nicole A. Kratochwil, Pari Malherbe, et al. · Journal of Chemical Information and Modeling · 59

Determination of key amino acids implicated in the actions of allosteric modulation by 3,3′-difluorobenzaldazine on rat mGlu5 receptors

2005 · Andreas Mühlemann, Natalie A. Ward, et al. · European Journal of Pharmacology · 57

Glucosylceramide synthase inhibition with lucerastat lowers globotriaosylceramide and lysosome staining in cultured fibroblasts from Fabry patients with different mutation types

2018 · R W D Welford, A Mühlemann, et al. · Human Molecular Genetics · 47

A Sendai Virus Vector Leading to the Efficient Expression of Mutant M Proteins Interfering with Virus Particle Budding

1996 · Geneviève Mottet, Andreas Mühlemann, et al. · Virology · 30

Discovery of a New Class of Orexin 2 Receptor Agonists as a Potential Treatment for Narcolepsy

2025 · Davide Pozzi, Romain Siegrist, et al. · Journal of Medicinal Chemistry · 9

Lucerastat, an iminosugar for substrate reduction therapy in Fabry disease: preclinical evidence

2017 · Richard W.D. Welford, Andreas Mühlemann, et al. · Molecular Genetics and Metabolism · 9

Constitutive activity modulation of human metabotropic glutamate 5a receptors in HEK293 cells: a role for key amino‐terminal cysteine residues

2005 · Andreas Mühlemann, Catherine Diener, et al. · British Journal of Pharmacology · 7

IDOR-1104-0086, a novel Kv7 channel activator with antiseizure effects in rodents

2025 · Melanie Kessler, Andreas Mühlemann, et al. · Neuropharmacology · 5

Discovery and In-Vivo Characterization of Kv7 Channel Openers through a Phenotypic Approach

2025 · Romain Siegrist, Olivier Bezençon, et al. · Journal of Medicinal Chemistry · 5

Sinbaglustat is efficacious in GM2 gangliosidosis primarily through inhibition of GBA2 rather than GCS

2025 · Michel A. Steiner, Catherine Vaillant, et al. · Molecular Therapy Advances · 2

Functional study of neuronal calcium sensor-1 (NCS-1) in yeast and mice : a role for NCS-1 in learning and memory

2005 · Mühlemann, Andreas · Archive ouverte UNIGE (University of Geneva)

Works count: 14

Citation count: 610

H-index: 8

I10-index: 6