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Tse‐I Lin

Observed names: T. Lin, Tse-I Lin, Tse-I. Lin, Tse–I Lin
OpenAlex ID: A5003454997
In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435
2010 · Oliver Lenz, Thierry Verbinnen, et al. · Antimicrobial Agents and Chemotherapy · 218
In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor
2009 · Tse-I Lin, Oliver Lenz, et al. · Antimicrobial Agents and Chemotherapy · 195
Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350
2008 · Pierre Raboisson, Herman de Kock, et al. · Bioorganic & Medicinal Chemistry Letters · 146
Induced‐Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target
2010 · Maxwell D. Cummings, Jimmy Lindberg, et al. · Angewandte Chemie International Edition · 98
Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)
2020 · Xuan G. Luong, Sarah K. Stevens, et al. · PLoS ONE · 76
Tracking the Evolution of MultipleIn VitroHepatitis C Virus Replicon Variants under Protease Inhibitor Selection Pressure by 454 Deep Sequencing
2010 · Thierry Verbinnen, Herwig Van Marck, et al. · Journal of Virology · 68
1,5-Benzodiazepine inhibitors of HCV NS5B polymerase
2009 · David McGowan, Origène Nyanguile, et al. · Bioorganic & Medicinal Chemistry Letters · 60
2′-Deoxy-2′-spirocyclopropylcytidine Revisited: A New and Selective Inhibitor of the Hepatitis C Virus NS5B Polymerase
2010 · Tim H. M. Jonckers, Tse-I Lin, et al. · Journal of Medicinal Chemistry · 56
Antiviral Suppression vs Restoration of RIG-I Signaling by Hepatitis C Protease and Polymerase Inhibitors
2008 · Yuqiong Liang, Hisashi Ishida, et al. · Gastroenterology · 50
Nucleotide Prodrugs of 2′-Deoxy-2′-spirooxetane Ribonucleosides as Novel Inhibitors of the HCV NS5B Polymerase
2013 · Tim H. M. Jonckers, Koen Vandyck, et al. · Journal of Medicinal Chemistry · 48
Discovery and Early Development of TMC647055, a Non-Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase
2013 · Maxwell D. Cummings, Tse-I Lin, et al. · Journal of Medicinal Chemistry · 39
Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055
2012 · Sandrine Vendeville, Tse-I. Lin, et al. · Bioorganic & Medicinal Chemistry Letters · 39
Structure‐Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties
2012 · Maxwell D. Cummings, Tse‐I Lin, et al. · Angewandte Chemie International Edition · 39
Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH
2024 · Koen Vandyck, David C. McGowan, et al. · Journal of Medicinal Chemistry · 38
Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors
2008 · Pierre Raboisson, Tse-I Lin, et al. · Bioorganic & Medicinal Chemistry Letters · 28
Discovery of 1-((2R,4aR,6R,7R,7aR)-2-Isopropoxy-2-oxidodihydro-4H,6H-spiro[furo[3,2-d][1,3,2]dioxaphosphinine-7,2′-oxetan]-6-yl)pyrimidine-2,4(1H,3H)-dione (JNJ-54257099), a 3′-5′-Cyclic Phosphate Ester Prodrug of 2′-Deoxy-2′-Spirooxetane Uridine Triphosphate Useful for HCV Inhibition
2016 · Tim H. M. Jonckers, Abdellah Tahri, et al. · Journal of Medicinal Chemistry · 25
Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: Exploration of P2 quinazoline substituents
2010 · Magnus Nilsson, Anna Karin Belfrage, et al. · Bioorganic & Medicinal Chemistry Letters · 25
Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors
2008 · Sandrine Vendeville, Magnus Nilsson, et al. · Bioorganic & Medicinal Chemistry Letters · 24
JNJ-64794964 (AL-034/TQ-A3334), a TLR7 agonist, induces sustained anti-HBV activity in AAV/HBV mice via non-cytolytic mechanisms
2021 · Florence Herschke, Chris Li, et al. · Antiviral Research · 21
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Discovery of 4′-azido-2′-deoxy-2′-C-methyl cytidine and prodrugs thereof: A potent inhibitor of Hepatitis C virus replication
2012 · Magnus Nilsson, Genadiy Kalayanov, et al. · Bioorganic & Medicinal Chemistry Letters · 20
Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series
2012 · David McGowan, Sandrine Vendeville, et al. · Bioorganic & Medicinal Chemistry Letters · 15
Evaluation of the anti-hepatitis C virus effect of novel potent, selective, and orally bioavailable JNK and VEGFR kinase inhibitors
2007 · Pierre Raboisson, Oliver Lenz, et al. · Bioorganic & Medicinal Chemistry Letters · 15
Analysis of the Iron-Sulfur Clusters Within the Complex I (NADH: Ubiquinone Oxidoreductase) Isolated from Potato Tuber Mitochondria
1995 · Tse‐I Lin, Vladimir D. Sled, et al. · European Journal of Biochemistry · 12
Development of a high-content screening assay to identify compounds interfering with the formation of the hepatitis C virus replication complex
2010 · Jan Martin Berke, Denis Fenistein, et al. · Journal of Virological Methods · 10
Safety, pharmacokinetics, and antiviral activity of the class II capsid assembly modulator ALG-000184 in subjects with chronic hepatitis B
2022 · Man-Fung Yuen, Kosh Agarwal, et al. · Journal of Hepatology · 9
Works count: 60
Citation count: 1,445
H-index: 20
I10-index: 24
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