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Karin V. Niessen

Observed names: K. Niessen, K. V. Niessen, K.V. Niessen, Karin Niessen, Karin Veronika Niessen, Niessen, Karin, Niessen, Karin V., Niessen, Karin Veronika
ORCID: 0009-0008-6810-5294
Observed ORCID: 0009-0008-6810-5294
OpenAlex ID: A5003926084
Diagnostics and treatment of nerve agent poisoning—current status and future developments
2020 · Niko Amend, Karin V. Niessen, et al. · Annals of the New York Academy of Sciences · 66
Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro
2012 · T. Seeger, M. Eichhorn, et al. · Toxicology · 58
Interaction of bispyridinium compounds with the orthosteric binding site of human α7 and Torpedo californica nicotinic acetylcholine receptors (nAChRs)
2011 · K.V. Niessen, J.E.H. Tattersall, et al. · Toxicology Letters · 37
Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning
2017 · Corinna Scheffel, Karin V. Niessen, et al. · Toxicology Letters · 26
Development of MS Binding Assays targeting the binding site of MB327 at the nicotinic acetylcholine receptor
2017 · S. Sichler, G. Höfner, et al. · Toxicology Letters · 25
In vitro pharmacological characterization of the bispyridinium non-oxime compound MB327 and its 2- and 3-regioisomers
2017 · K.V. Niessen, T. Seeger, et al. · Toxicology Letters · 25
Affinities of bispyridinium non-oxime compounds to [3H]epibatidine binding sites of Torpedo californica nicotinic acetylcholine receptors depend on linker length
2013 · K.V. Niessen, T. Seeger, et al. · Chemico-Biological Interactions · 25
Functional analysis of Torpedo californica nicotinic acetylcholine receptors in multiple activation states by SSM-based electrophysiology
2016 · K.V. Niessen, S. Muschik, et al. · Toxicology Letters · 23
Competition radioligand binding assays for the investigation of bispyridinium compound affinities to the human muscarinic acetylcholine receptor subtype 5 (hM5)
2012 · K. V. Niessen, J. E. H. Tattersall, et al. · Drug Testing and Analysis · 18
Competitive MS Binding Assays for Dopamine D2 Receptors Employing Spiperone as a Native Marker
2005 · Karin V. Niessen, Georg Höfner, et al. · ChemBioChem · 18
Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor
2017 · Thomas Wein, Georg Höfner, et al. · Toxicology Letters · 17
A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment
2022 · Jesko Kaiser, Christoph G.W. Gertzen, et al. · Toxicology Letters · 15
Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity—An in vitro structure-activity analysis
2017 · Corinna Scheffel, Karin V. Niessen, et al. · Toxicology Letters · 15
Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor
2018 · Sebastian Rappenglück, Sonja Sichler, et al. · ChemMedChem · 11
MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor
2024 · Valentin Nitsche, Georg Höfner, et al. · Toxicology Letters · 10
Regioselective and Transition-Metal-Free Addition of tert-Butyl Magnesium Reagents to Pyridine Derivatives: A Convenient Method for the Synthesis of 3-Substituted 4-tert-Butylpyridine Derivatives
2017 · Sebastian Rappenglück, Karin Niessen, et al. · Synthesis · 10
Restoration of nerve agent inhibited muscle force production in human intercostal muscle strips with HI 6
2011 · T. Seeger, K.V. Niessen, et al. · Toxicology Letters · 10
Synthesis of a Series of Non‐Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor
2018 · Sebastian Rappenglück, Sonja Sichler, et al. · ChemMedChem · 9
Screening for new ligands of the MB327-PAM-1 binding site of the nicotinic acetylcholine receptor
2024 · Sonja Sichler, Georg Höfner, et al. · Toxicology Letters · 7
New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling
2018 · Thomas Wein, Klaus T. Wanner, et al. · Current Computer - Aided Drug Design · 6
Identification of ligands binding to MB327-PAM-1, a binding pocket relevant for resensitization of nAChRs
2024 · Jesko Kaiser, Christoph G.W. Gertzen, et al. · Toxicology Letters · 4
Synthesis and biological evaluation of novel MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after intoxication with nerve agents
2024 · Tamara Bernauer, Valentin Nitsche, et al. · Toxicology Letters · 3
Development of a scintillation proximity assay for [3H]epibatidine binding sites of Tetronarce californica muscle-type nicotinic acetylcholine receptor
2024 · Fabian Springer, Marian Freisleben, et al. · Toxicology Letters · 2
Methyltransferase-Inhibitoren – mögliche Schlüsselstruktur für die Entwicklung neuer Behandlungsmöglichkeiten bei Nervenkampfstoffvergiftungen?
2025 · Springer, Fabian, Muschik, Sebastian, et al. · FIRe-Publikationsserver des FIZBw
Characterization of cell membrane fragments containing muscle type nAChR from Tetronarce californica after preparation using high pressure homogenization
2025 · Fabian Springer, Marian Freisleben, et al. · Toxicology Letters
Works count: 36
Citation count: 440
H-index: 13
I10-index: 17
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