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Karen D. Brown

Observed names: K. Brown, Karen Brown, Karen D Brown
OpenAlex ID: A5004546393
Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban
2016 · Jack E. Ansell, Sasha H. Bakhru, et al. · Thrombosis and Haemostasis · 147
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Discovery of an Orally Efficacious Inhibitor of Coagulation Factor Xa Which Incorporates a Neutral P1Ligand
2003 · Yong Mi Choi-Sledeski, Robert Kearney, et al. · Journal of Medicinal Chemistry · 80
Optimization of the β-Aminoester class of factor Xa inhibitors. part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity
2002 · Kevin R Guertin, Charles J Gardner, et al. · Bioorganic & Medicinal Chemistry Letters · 52
Design and Structure−Activity Relationships of Potent and Selective Inhibitors of Blood Coagulation Factor Xa
1999 · William R. Ewing, Michael R. Becker, et al. · Journal of Medicinal Chemistry · 42
Sulfonamidopyrrolidinone Factor Xa Inhibitors: Potency and Selectivity Enhancements via P-1 and P-4 Optimization
1999 · Yong Mi Choi-Sledeski, Daniel G. McGarry, et al. · Journal of Medicinal Chemistry · 39
Identification and Initial Structure−Activity Relationships of a Novel Class of Nonpeptide Inhibitors of Blood Coagulation Factor Xa
1998 · Scott I. Klein, Mark Czekaj, et al. · Journal of Medicinal Chemistry · 39
Abstract 18809: PER977: A Synthetic Small Molecule Which Reverses Over-Dosage and Bleeding by the New Oral Anticoagulants
2013 · Sasha Bakhru, Bryan Laulicht, et al. · Circulation · 32
Antithrombotic efficacy of RPR208566, a novel factor Xa inhibitor, in a rat model of carotid artery thrombosis
2000 · Christopher Heran, Suzanne Morgan, et al. · European Journal of Pharmacology · 32
Pharmacological Characterization of a Novel Factor Xa Inhibitor, FXV673
2001 · Valeria Chu, Karen Brown, et al. · Thrombosis Research · 28
Synthesis, SAR and in vivo activity of novel thienopyridine sulfonamide pyrrolidinones as factor Xa inhibitors
1999 · Michael R. Becker, William R. Ewing, et al. · Bioorganic & Medicinal Chemistry Letters · 25
Aminoisoquinolines: Design and synthesis of an orally active benzamidine isostere for the inhibition of factor XA
1999 · Y.M. Choi-Sledeski, M.R. Becker, et al. · Bioorganic & Medicinal Chemistry Letters · 23
Solid-phase parallel synthesis of azarene pyrrolidinones as factor Xa inhibitors
2000 · Yong Gong, Michael Becker, et al. · Bioorganic & Medicinal Chemistry Letters · 19
Pharmacodynamic Activity and Antithrombotic Efficacy of RPR120844, a Novel Inhibitor of Coagulation Factor Xa
1999 · Robert J. Leadley, Suzanne R. Morgan, et al. · Journal of Cardiovascular Pharmacology · 19
RPR120844, a Novel, Specific Inhibitor of Coagulation Factor Xa Inhibits Venous Thrombosis in the Rabbit
1999 · Ross Bentley, Suzanne Morgan, et al. · Thrombosis and Haemostasis · 19
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Optimization of the β-Aminoester class of factor Xa inhibitors. part 1: P4 and side-Chain modifications for improved In vitro potency
2002 · Mark Czekaj, Scott I Klein, et al. · Bioorganic & Medicinal Chemistry Letters · 18
In Vitro Characterization of a Novel Factor Xa Inhibitor, RPR 130737
2000 · Valeria Chu, Karen Brown, et al. · Thrombosis Research · 16
Design of a New Class of Orally Active Fibrinogen Receptor Antagonists
1998 · Scott I. Klein, Bruce F. Molino, et al. · Journal of Medicinal Chemistry · 16
Amido-(propyl and allyl)-hydroxybenzamidines: development of achiral inhibitors of factor Xa
2000 · Yong Gong, Henry W. Pauls, et al. · Bioorganic & Medicinal Chemistry Letters · 14
Role of Short-Term Inhibition of Factor Xa by FXV673 in Arterial Passivation: A Study in a Chronic Model of Thrombosis in Conscious Dogs
2001 · Sam S. Rebello, Charles J. Kasiewski, et al. · Journal of Cardiovascular Pharmacology · 12
Nonbenzamidine compounds as selective factor xa inhibitors
2000 · Wei He, Barbara Hanney, et al. · Bioorganic & Medicinal Chemistry Letters · 12
Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors
2002 · Wei He, Barbara Hanney, et al. · Bioorganic & Medicinal Chemistry Letters · 7
ChemInform Abstract: Benzimidazoles and Isosteric Compounds as Potent and Selective Factor Xa Inhibitors
2002 · Wei He, Barbara Hanney, et al. · ChemInform
ChemInform Abstract: Amido‐(Propyl and Allyl)‐hydroxybenzamidines: Development of Achiral Inhibitors of Factor Xa.
2000 · Yong Gong, Henry W. Pauls, et al. · ChemInform
Works count: 23
Citation count: 691
H-index: 16
I10-index: 20
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