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Jean‐Christophe François

Observed names: FRANCOIS, Jean-Christophe, Francois, Jean Christophe, J C François, J-C François, J-C. Francois, J. -C. François, J. C. Francois, J.-C. Francois, J.-C. François, J.C. Francois, J.C. François, Jean C. François, Jean Christophe Francois, Jean-Christophe FRANÇOIS, Jean-Christophe Francois, Jean-Christophe François, Jean-Christophe François, Jean-christophe François
Observed institutions: École Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, National Museum of Natural History, Inserm, Sorbonne Université, Institut de Biologie et de Chimie des Protéines, Institute of Chemical Biology and Fundamental Medicine, Hôpital Saint-Antoine, Muséum national d'Histoire naturelle, Siberian Branch of the Russian Academy of Sciences, Centre de Recherche Saint-Antoine, Evolution des Régulations Endocriniennes, Structure et Instabilité des Génomes, Université Pierre-et-Marie-Curie
ORCID: 0000-0003-4480-1822
Observed ORCID: 0000-0003-4480-1822
OpenAlex ID: A5005575509
Sequence-specific intercalating agents: intercalation at specific sequences on duplex DNA via major groove recognition by oligonucleotide-intercalator conjugates.
1989 · J S Sun, J C François, et al. · Proceedings of the National Academy of Sciences · 179
Sequence-specific recognition and cleavage of duplex DNA via triple-helix formation by oligonucleotides covalently linked to a phenanthroline-copper chelate.
1989 · J C François, T Saison-Behmoaras, et al. · Proceedings of the National Academy of Sciences · 150
Sequence-specific recognition of the major groove of DNA by oligodeoxynucleotides via triple helix formation. Footprinting studies
1988 · Jean-Christophe François, Tula Saison-Behmoaras, et al. · Nucleic Acids Research · 137
Temporal Variations in the Dynamics of Potentially Microcystin-Producing Strains in a Bloom-Forming Planktothrix agardhii (Cyanobacterium) Population
2008 · Enora Briand, Muriel Gugger, et al. · Applied and Environmental Microbiology · 132
Inhibition of restriction endonuclease cleavage via triple helix formation by homopyrimidine oligonucleotides
1989 · Jean Christophe Francois, Tula Saison-Behmoaras, et al. · Biochemistry · 132
DNA enzymes as potential therapeutics: towards clinical application of 10-23 DNAzymes
2015 · Alesya A Fokina, Dmitry A Stetsenko, et al. · Expert Opinion on Biological Therapy · 108
Triple-helix formation by alpha oligodeoxynucleotides and alpha oligodeoxynucleotide-intercalator conjugates.
1991 · J S Sun, C Giovannangeli, et al. · Proceedings of the National Academy of Sciences · 96
Sequence-targeted Cleavage of single- and Double-stranded DNA by Oligothymidylates Covalently Linked to 1,10-Phenanthroline
1989 · J C François, T Saison-Behmoaras, et al. · Journal of Biological Chemistry · 95
Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway
2014 · N Milosch, G Tanriöver, et al. · Cell Death and Disease · 86
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The Alzheimer’s disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons
2017 · Caroline George, Géraldine Gontier, et al. · Brain · 84
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Global quantitative analysis of protein expression and phosphorylation status in the liver of the medaka fish (Oryzias latipes) exposed to microcystin-LR
2007 · Karim Mezhoud, Danièle Praseuth, et al. · Aquatic Toxicology · 77
Effect of competing self-structure on triplex formation with purine-rich oligodeoxynucleotides containing GA repeats
1995 · Sarah B. Noonberg, Jean-Christophe François, et al. · Nucleic Acids Research · 71
Proteomic and phosphoproteomic analysis of cellular responses in medaka fish (Oryzias latipes) following oral gavage with microcystin-LR
2008 · K. Mezhoud, A.L. Bauchet, et al. · Toxicon · 58
Periodic cleavage of poly(dA) by oligothymidylates covalently linked to the 1,10-phenanthroline-copper complex
1988 · Jean Christophe Francois, Tula Saison-Behmoaras, et al. · Biochemistry · 55
Unusual DNA Conformations: Implications for Telomeres
2002 · Martin Mills, Laurent Lacroix, et al. · Anti-Cancer Agents in Medicinal Chemistry · 52
Sequence-targeted cleavage of nucleic acids by oligo-[.alpha.]thymidylate-phenanthroline conjugates: parallel and antiparallel double helices are formed with DNA and RNA, respectively
1988 · Jian Sheng Sun, Jean Christophe Francois, et al. · Biochemistry · 52
Targeting Insulin-like Growth Factor I with 10–23 DNAzymes: 2′-O-Methyl Modifications in the Catalytic Core Enhance mRNA Cleavage
2012 · Alesya A. Fokina, Mariya I. Meschaninova, et al. · Biochemistry · 50
A hybrid CMV-H1 construct improves efficiency of PEI-delivered shRNA in the mouse brain
2007 · Z. Hassani, J.-C. Francois, et al. · Nucleic Acids Research · 46
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Small Interfering RNA Targeted to IGF-IR Delays Tumor Growth and Induces Proinflammatory Cytokines in a Mouse Breast Cancer Model
2012 · Tiphanie Durfort, Mercedes Tkach, et al. · PLoS ONE · 43
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Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction
2017 · Rigo Cintron-Colon, Manuel Sanchez-Alavez, et al. · Proceedings of the National Academy of Sciences · 36
Recognition and cleavage of hairpin structures in nucleic acids by oligodeoxynucleotides
1994 · Jean-Christophe François, Nguyen T. Thuong, et al. · Nucleic Acids Research · 35
Human glioma cells transformed by IGF-I triple helix technology show immune and apoptotic characteristics determining cell selection for gene therapy of glioblastoma
2001 · A Ly, H T Duc, et al. · Molecular Pathology · 32
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Sequence-specific artificial endonucleases
1989 · Claude Hélène, Nguyen T. Thuong, et al. · Trends in biotechnology · 32
Chronodisruption in lung cancer and possible therapeutic approaches
2011 · Gianluigi Mazzoccoli, Roberto Tarquini, et al. · Biomedicine & Pharmacotherapy · 25
Recognition and Cleavage of Single-Stranded DNA Containing Hairpin Structures by Oligonucleotides Forming Both Watson-Crick and Hoogsteen Hydrogen Bonds
1995 · Jean-Christophe Francois, Claude Helene · Biochemistry · 25
Works count: 71
Citation count: 2,174
H-index: 25
I10-index: 40
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