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Dian Su

Linker Design Impacts Antibody-Drug Conjugate Pharmacokinetics and Efficacy via Modulating the Stability and Payload Release Efficiency
2021 · Dian Su, Donglu Zhang · Frontiers in Pharmacology · 184
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Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers with Enhanced Protease Specificity
2017 · BinQing Wei, Janet Gunzner-Toste, et al. · Journal of Medicinal Chemistry · 113
Site-Specific Trastuzumab Maytansinoid Antibody–Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering
2014 · Thomas H. Pillow, Janet Tien, et al. · Journal of Medicinal Chemistry · 108
Modulating Antibody–Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification
2018 · Dian Su, Katherine R. Kozak, et al. · Bioconjugate Chemistry · 83
A homogeneous high-DAR antibody–drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides
2022 · Neelie Zacharias, Vladimir N. Podust, et al. · Chemical Science · 69
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Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein– and Peptide–Payload Conjugates: Application to THIOMAB Antibody–Drug Conjugates
2017 · Jack D. Sadowsky, Thomas H. Pillow, et al. · Bioconjugate Chemistry · 60
Custom-Designed Affinity Capture LC-MS F(ab′)2 Assay for Biotransformation Assessment of Site-Specific Antibody Drug Conjugates
2016 · Dian Su, Carl Ng, et al. · Analytical Chemistry · 60
High-Resolution Accurate-Mass Mass Spectrometry Enabling In-Depth Characterization of in Vivo Biotransformations for Intact Antibody-Drug Conjugates
2017 · Jintang He, Dian Su, et al. · Analytical Chemistry · 57
Intratumoral Payload Concentration Correlates with the Activity of Antibody–Drug Conjugates
2018 · Donglu Zhang, Shang-Fan Yu, et al. · Molecular Cancer Therapeutics · 45
2019 White Paper on Recent Issues in Bioanalysis: Chromatographic Assays (Part 1 – Innovation in Small Molecules and Oligonucleotides & Mass Spectrometric Method Development Strategies for Large Molecule Bioanalysis)
2019 · Christine Fandozzi, Christopher Evans, et al. · Bioanalysis · 41
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2017 White Paper on Recent Issues in Bioanalysis: Rise of Hybrid LBA/LCMS Immunogenicity Assays (Part 2: Hybrid LBA/LCMS Biotherapeutics, Biomarkers & Immunogenicity Assays and Regulatory Agencies’ Inputs)
2017 · Hendrik Neubert, An Song, et al. · Bioanalysis · 40
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Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody–Drug Conjugates with Phenol-Containing Payloads
2018 · Donglu Zhang, Hoa Le, et al. · Bioconjugate Chemistry · 37
2021 White Paper on Recent Issues in Bioanalysis: Mass Spec of Proteins, Extracellular Vesicles, CRISPR, Chiral Assays, Oligos; Nanomedicines Bioanalysis; ICH M10 Section 7.1; Non-Liquid & Rare Matrices; Regulatory Inputs ( Part 1A – Recommendations on Endogenous Compounds, Small Molecules, Complex Methods, Regulated Mass Spec of Large Molecules, Small Molecule, PoC & Part 1B - Regulatory Agencies' Inputs on Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy and Vaccine)
2022 · Surinder Kaur, Stephen C Alley, et al. · Bioanalysis · 36
Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
2019 · Donglu Zhang, Peter S. Dragovich, et al. · Drug Metabolism and Disposition · 34
LC–MS Challenges in Characterizing and Quantifying Monoclonal Antibodies (mAb) and Antibody-Drug Conjugates (ADC) in Biological Samples
2018 · Cong Wei, Dian Su, et al. · Current Pharmacology Reports · 31
Chemical de-conjugation for investigating the stability of small molecule drugs in antibody-drug conjugates
2015 · Tao Chen, Dian Su, et al. · Journal of Pharmaceutical and Biomedical Analysis · 29
Improved translation of stability for conjugated antibodies using an in vitro whole blood assay
2020 · Aimee Fourie-O’Donohue, Phillip Y. Chu, et al. · mAbs · 22
Antibody–Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo
2019 · Dian Su, Jinhua Chen, et al. · Bioconjugate Chemistry · 21
An Integrated Strategy for Assessing the Metabolic Stability and Biotransformation of Macrocyclic Peptides in Drug Discovery toward Oral Delivery
2022 · Yukuang Guo, Shaofei Ji, et al. · Analytical Chemistry · 20
Biosynthetic Strategies for Macrocyclic Peptides
2021 · Wei Wang, S. Cyrus Khojasteh, et al. · Molecules · 20
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Future of Biotransformation Science in the Pharmaceutical Industry
2021 · Valerie M. Kramlinger, Deepak Dalvie, et al. · Drug Metabolism and Disposition · 17
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Preclinical pharmacokinetics and pharmacodynamics of DCLL9718A: An antibody-drug conjugate for the treatment of acute myeloid leukemia
2018 · Douglas D. Leipold, Isabel Figueroa, et al. · mAbs · 17
Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1
2024 · John C. Tellis, BinQing Wei, et al. · ACS Medicinal Chemistry Letters · 16
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PBPK Modeling to Predict Clinical Drug–Drug Interaction and Impact of Hepatic Impairment for an ADC With the Payload Auristatin F‐Hydroxypropylamide
2025 · Niyanta Kumar, Vaishali Dixit, et al. · CPT Pharmacometrics & Systems Pharmacology · 5
Identification of a Discrete Diglucuronide of GDC-0810 in Human Plasma after Oral Administration
2023 · Chenghong Zhang, Dian Su, et al. · Drug Metabolism and Disposition · 4
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Works count: 33
Citation count: 1,214
H-index: 20
I10-index: 24
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