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Nagakumar Bharatham
Observed names:
Bharatham, Nagakumar,
Bharatham, Nagakumar;Bharatham, Kavitha;Lee, Keun-Woo;,
N. Bharatham,
bharatham, nagakumar
Institutions:
National Centre for Biological Sciences,
University of Trans-Disciplinary Health Sciences and Technology
Observed institutions:
Tata Institute of Fundamental Research,
St. Jude Children's Research Hospital,
Nanyang Technological University,
Gyeongsang National University,
National Centre for Biological Sciences,
University of Trans-Disciplinary Health Sciences and Technology
show all 6
ORCID:
0000-0003-4904-7726
Observed ORCID:
0000-0003-4904-7726
OpenAlex ID:
A5006084918
Binding mode analyses and pharmacophore model development for sulfonamide chalcone derivatives, a new class of α-glucosidase inhibitors
2007
·
Kavitha Bharatham
, Nagakumar Bharatham
, et al.
·
Journal of Molecular Graphics and Modelling
·
107
PtdIns(3)P-bound UVRAG coordinates Golgi–ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex
2013
·
Shanshan He
, Duojiao Ni
, et al.
·
Nature Cell Biology
·
92
Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae
2021
·
Nagakumar Bharatham
, Purnendu Bhowmik
, et al.
·
Nature Communications
·
78
PDF
Pharmacophore identification and virtual screening for methionyl-tRNA synthetase inhibitors
2006
·
Nagakumar Bharatham
, Kavitha Bharatham
, et al.
·
Journal of Molecular Graphics and Modelling
·
50
Macro Histone H2A1.2 (MacroH2A1) Protein Suppresses Mitotic Kinase VRK1 during Interphase
2011
·
Wanil Kim
, Goutam Chakraborty
, et al.
·
Journal of Biological Chemistry
·
49
PDF
NMR Solution Structure of Human Vaccinia-related Kinase 1 (VRK1) Reveals the C-terminal Tail Essential for Its Structural Stability and Autocatalytic Activity
2011
·
Joon Shin
, Goutam Chakraborty
, et al.
·
Journal of Biological Chemistry
·
49
PDF
Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer
2020
·
P. Jake Slavish
, Liying Chi
, et al.
·
Cancer Research
·
43
Molecular Basis of Bcl-XL-p53 Interaction: Insights from Molecular Dynamics Simulations
2011
·
Nagakumar Bharatham
, Seung-Wook Chi
, et al.
·
PLoS ONE
·
40
PDF
Ligand Binding Mode Prediction by Docking: Mdm2/Mdmx Inhibitors as a Case Study
2013
·
Nagakumar Bharatham
, Kavitha Bharatham
, et al.
·
Journal of Chemical Information and Modeling
·
36
Monitoring Ligand-Induced Protein Ordering in Drug Discovery
2016
·
Christy R. Grace
, David Ban
, et al.
·
Journal of Molecular Biology
·
33
Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C‐terminal pentapeptide
2009
·
Reema Alag
, Nagakumar Bharatham
, et al.
·
Protein Science
·
33
PDF
Molecular dynamics simulation study of PTP1B with allosteric inhibitor and its application in receptor based pharmacophore modeling
2008
·
Kavitha Bharatham
, Nagakumar Bharatham
, et al.
·
Journal of Computer-Aided Molecular Design
·
33
Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors
2017
·
William R. Shadrick
, Peter J. Slavish
, et al.
·
Bioorganic & Medicinal Chemistry
·
32
NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35
2010
·
Reema Alag
, Insaf A. Qureshi
, et al.
·
Protein Science
·
31
PDF
Analysis of the Active-Site Mechanism of Tyrosyl-DNA Phosphodiesterase I: A Member of the Phospholipase D Superfamily
2011
·
Stefan Gajewski
, Evan Q. Comeaux
, et al.
·
Journal of Molecular Biology
·
30
Targeting FK506 Binding Proteins to Fight Malarial and Bacterial Infections:Current Advances and Future Perspectives
2011
·
N. Bharatham
, M. W. Chang
, et al.
·
Current Medicinal Chemistry
·
29
Nitrothiophene carboxamides, a novel narrow spectrum antibacterial series: Mechanism of action and Efficacy
2018
·
Shahul Hameed P
, Nagakumar Bharatham
, et al.
·
Scientific Reports
·
28
PDF
The role of ZA channel water-mediated interactions in the design of bromodomain-selective BET inhibitors
2018
·
Nagakumar Bharatham
, Peter J. Slavish
, et al.
·
Journal of Molecular Graphics and Modelling
·
27
BWC0977, a broad-spectrum antibacterial clinical candidate to treat multidrug resistant infections
2024
·
Shahul Hameed P
, Harish Kotakonda
, et al.
·
Nature Communications
·
21
PDF
A strategy to identify a ketoreductase that preferentially synthesizes pharmaceutically relevant (S)-alcohols using whole-cell biotransformation
2018
·
Saiful F. Haq
, Anirudh P. Shanbhag
, et al.
·
Microbial Cell Factories
·
21
PDF
Performance of a docking/molecular dynamics protocol for virtual screening of nutlin-class inhibitors of Mdmx
2017
·
Nagakumar Bharatham
, Kristin E. Finch
, et al.
·
Journal of Molecular Graphics and Modelling
·
20
Azaindole Based Potentiator of Antibiotics against Gram-Negative Bacteria
2021
·
Sreevalli Sharma
, Ranga Rao
, et al.
·
ACS Infectious Diseases
·
17
Combating Multidrug‐Resistant Bacteria by Integrating a Novel Target Site Penetration and Receptor Binding Assay Platform Into Translational Modeling
2021
·
Yinzhi Lang
, Nirav R. Shah
, et al.
·
Clinical Pharmacology & Therapeutics
·
13
PDF
Pharmacophore modeling for protein tyrosine phosphatase 1B inhibitors
2007
·
Kavitha Bharatham
, Nagakumar Bharatham
, et al.
·
Archives of Pharmacal Research
·
12
Suprafenacine, an Indazole-Hydrazide Agent, Targets Cancer Cells Through Microtubule Destabilization
2014
·
Bo-Hwa Choi
, Souvik Chattopadhaya
, et al.
·
PLoS ONE
·
11
PDF
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Works count:
64
Citation count:
997
H-index:
20
I10-index:
26
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