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Patrick H. van Berkel

Observed names: P.H van Berkel, P.H. Van Berkel, Patrick H Van Berkel, Patrick H van Berkel, Patrick H. Van Berkel, Patrick H. Van Berkel, Patrick Van Berkel
ORCID: 0000-0002-7315-0347
Observed ORCID: 0000-0002-7315-0347
OpenAlex ID: A5006107477
ADCT-402, a PBD dimer–containing antibody drug conjugate targeting CD19-expressing malignancies
2018 · Francesca Zammarchi, Simon Corbett, et al. · Blood · 188
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Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine
2018 · John A. Hartley, Michael J. Flynn, et al. · Scientific Reports · 134
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ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer–Containing Antibody–Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies
2016 · Michael J. Flynn, Francesca Zammarchi, et al. · Molecular Cancer Therapeutics · 128
CD25-targeted antibody–drug conjugate depletes regulatory T cells and eliminates established syngeneic tumors via antitumor immunity
2020 · Francesca Zammarchi, Karin Havenith, et al. · Journal for ImmunoTherapy of Cancer · 85
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Integrin αvβ6-specific therapy for pancreatic cancer developed from foot-and-mouth-disease virus
2020 · Kate M. Moore, Ami Desai, et al. · Theranostics · 50
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Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer
2018 · Song Cho, Francesca Zammarchi, et al. · Molecular Cancer Therapeutics · 50
Selective haematological cancer eradication with preserved haematopoiesis
2024 · Simon Garaudé, Romina Marone, et al. · Nature · 49
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The Role of Specific ATP-Binding Cassette Transporters in the Acquired Resistance to Pyrrolobenzodiazepine Dimer–Containing Antibody–Drug Conjugates
2020 · Simon Corbett, Shiran Huang, et al. · Molecular Cancer Therapeutics · 33
A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma
2024 · Amber K. Hamilton, Alexander B. Radaoui, et al. · Cancer Cell · 28
Anti-CD45 PBD-based antibody-drug conjugates are effective targeted conditioning agents for gene therapy and stem cell transplant
2024 · Jenny Yeung, Aiyin Liao, et al. · Molecular Therapy · 25
Targeting CD19-positive lymphomas with the antibodydrug conjugate loncastuximab tesirine: preclinical evidence of activity as a single agent and in combination therapy
2024 · Chiara Tarantelli, David Wald, et al. · Haematologica · 21
APOMAB Antibody–Drug Conjugates Targeting Dead Tumor Cells are Effective In Vivo
2018 · Alexander H. Staudacher, Yanrui Li, et al. · Molecular Cancer Therapeutics · 20
ADCT-502, a novel pyrrolobenzodiazepine (PBD)-based antibody–drug conjugate (ADC) targeting low HER2-expressing solid cancers
2016 · F. Zammarchi, S. Chivers, et al. · European Journal of Cancer · 16
ADCT-602, a Novel PBD Dimer–containing Antibody–Drug Conjugate for Treating CD22-positive Hematologic Malignancies
2024 · Francesca Zammarchi, Karin E. Havenith, et al. · Molecular Cancer Therapeutics · 14
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Integrin-αvβ6 targeted peptide-toxin therapy in a novel αvβ6-expressing immunocompetent model of pancreatic cancer
2024 · Nicholas F. Brown, Elizabeth R. Murray, et al. · Pancreatology · 13
Lineage dependence of the neuroblastoma surfaceome defines tumor cell state-dependent and -independent immunotherapeutic targets
2025 · Nathan M Kendsersky, Michal Odrobina, et al. · Neuro-Oncology · 12
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Abstract 744: ADCT-701, a novel pyrrolobenzodiazepine (PBD) dimer-based antibody-drug conjugate (ADC) targeting DLK1-expressing tumors
2018 · Francesca Zammarchi, Karin Havenith, et al. · Cancer Research · 10
Pre-Clinical Development of Adct-402, a Novel Pyrrolobenzodiazepine (PBD)-Based Antibody Drug Conjugate (ADC) Targeting CD19-Expressing B-Cell Malignancies
2015 · Francesca Zammarchi, David G. Williams, et al. · Blood · 10
Combination of Camidanlumab Tesirine, a CD25-Targeted ADC, with Gemcitabine Elicits Synergistic Anti-Tumor Activity in Preclinical Tumor Models
2020 · Asma Jabeen, Shiran Huang, et al. · Blood · 9
Mechanistic and Pharmacodynamic Studies of Adct-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies
2015 · Michael J. Flynn, Patrick H. van Berkel, et al. · Blood · 7
Abstract 2792A: Preclinical activity of ADCT-601, a novel pyrrolobenzodiazepine (PBD) dimer-based antibody-drug conjugate (ADC) targeting AXL-expressing tumors
2018 · Francesca Zammarchi, Karin Havenith, et al. · Cancer Research · 6
Targeting CD25 + lymphoma cells with the antibody–drug conjugate camidanlumab tesirine as a single agent or in combination with targeted agents
2024 · Filippo Spriano, Chiara Tarantelli, et al. · British Journal of Haematology · 5
Abstract 52: Mechanistic and benchmarking studies of ADCT-502, a pyrrolobenzodiazepine (PBD) dimer-containing antibody-drug conjugate (ADC) targeting HER2-expressing solid tumors
2017 · Francesca Zammarchi, Halla W. Reinert, et al. · Cancer Research · 5
Abstract 234: Pre-clinical characterization of 3A4-PL1601, a novel pyrrolobenzodiazepine (PBD) dimer-based antibody-drug conjugate (ADC) directed against KAAG1-expressing malignancies
2019 · Francesca Zammarchi, Francois Bertelli, et al. · Cancer Research · 4
DLK1 is a GATA1s-driven dependency and therapeutic target in Down syndrome–associated myeloid leukemia
2026 · Lonneke J. Verboon, Sonali P. Barwe, et al. · Blood Advances · 3
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Works count: 116
Citation count: 956
H-index: 14
I10-index: 18
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