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Francis M. Hughes

Observed names: F Hughes, F M Hughes, F. M. Hughes, F. Monty Hughes, F.M. Hughes, FRANCIS M. HUGHES, Francis Hughes, Francis M Hughes, Francis M Hughes Jr, Francis M Hughes Jr., Francis M. Hughes Jr, Francis M. Hughes Jr., Francis M. Hughes., Francis Monty Hughes, Hughes FM Jr, Hughes Jr., Francis M., Hughes, Francis, Hughes, Francis M.
Observed institutions: University of North Carolina at Charlotte, University of North Carolina at Chapel Hill, National Institutes of Health, Medical University of South Carolina, Duke University, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, Duke Medical Center, Duke University Hospital, Clemson University
ORCID: 0000-0003-3776-3653
Observed ORCID: 0000-0003-3776-3653
OpenAlex ID: A5006166397
A Primary Role for K+ and Na+ Efflux in the Activation of Apoptosis
1997 · Carl D. Bortner, Francis M. Hughes, et al. · Journal of Biological Chemistry · 555
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Biochemical Identification of Apoptosis (Programmed Cell Death) in Granulosa Cells: Evidence for a Potential Mechanism Underlying Follicular Atresia*
1991 · FRANCIS M. HUGHES, WILLIAM C. GOROSPE · Endocrinology · 513
Intracellular K+ Suppresses the Activation of Apoptosis in Lymphocytes
1997 · Francis M. Hughes, Carl D. Bortner, et al. · Journal of Biological Chemistry · 460
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Potassium is a critical regulator of apoptotic enzymes in vitro and in vivo
1999 · Francis M Hughes Jr., John A Cidlowski · Advances in Enzyme Regulation · 230
Cadmium-induced apoptosis in oyster hemocytes involves disturbance of cellular energy balance but no mitochondrial permeability transition
2004 · I. M. Sokolova, S. Evans, et al. · Journal of Experimental Biology · 208
Roles of cytoplasmic Ca2+ and intracellular Ca2+ stores in induction and suppression of apoptosis in S49 cells
1997 · X. Bian, F. M. Hughes, et al. · American Journal of Physiology-Cell Physiology · 164
Native Recombinant Cyclophilins A, B, and C Degrade DNA Independently of Peptidylprolyl cis-trans-Isomerase Activity
1997 · Jennifer W. Montague, Francis M. Hughes, et al. · Journal of Biological Chemistry · 162
Estrogen Regulation of Aquaporins in the Mouse Uterus: Potential Roles in Uterine Water Movement1
2003 · Elizabeth M. Jablonski, Nisha A. McConnell, et al. · Biology of Reproduction · 130
Decreased aquaporin expression leads to increased resistance to apoptosis in hepatocellular carcinoma
2006 · Elizabeth M. Jablonski, M. Adrian Mattocks, et al. · Cancer Letters · 123
Plasma membrane aquaporin activity can affect the rate of apoptosis but is inhibited after apoptotic volume decrease
2004 · Elizabeth M. Jablonski, Ashley N. Webb, et al. · American Journal of Physiology-Cell Physiology · 116
The biochemistry and molecular biology of glucocorticoid-induced apoptosis in the immune system.
1996 · J A Cidlowski, K L King, et al. · PubMed · 115
Water Permeability of an Ovarian Antral Follicle Is Predominantly Transcellular and Mediated by Aquaporins
2002 · Nisha A. McConnell, Raheela S. Yunus, et al. · Endocrinology · 113
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Interleukin-6: effects on and production by rat granulosa cells in vitro
1992 · W C Gorospe, F M Hughes, et al. · Endocrinology · 103
Apoptosis as a host defense mechanism in Crassostrea virginica and its modulation by Perkinsus marinus
2010 · Francis M. Hughes, Brent Foster, et al. · Fish & Shellfish Immunology · 90
The NLRP3 Inflammasome Mediates Inflammation Produced by Bladder Outlet Obstruction
2015 · Francis M. Hughes, Hayden M. Hill, et al. · The Journal of Urology · 79
Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation
2013 · Francis M. Hughes, Nivardo P. Vivar, et al. · American Journal of Physiology-Renal Physiology · 77
A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections
2020 · Jianxuan Wu, Byron W. Hayes, et al. · Nature Immunology · 71
Identification of Potassium-Dependent and -Independent Components of the Apoptotic Machinery in Mouse Ovarian Germ Cells and Granulosa Cells1
2000 · Gloria I. Perez, Daniel V. Maravei, et al. · Biology of Reproduction · 70
A necessary role for reduced intracellular potassium during the DNA degradation phase of apoptosis
1999 · Jennifer W Montague, Carl D Bortner, et al. · Steroids · 69
Delineation of the Signaling Pathways Involved in Glucocorticoid-Induced and Spontaneous Apoptosis of Rat Thymocytes
2000 · Cynthia L. Mann, Francis M. Hughes, et al. · Endocrinology · 59
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A novel urodynamic model for lower urinary tract assessment in awake rats
2015 · Marc P. Schneider, Francis M. Hughes, et al. · British Journal of Urology · 58
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Glucocorticoid-induced thymocyte apoptosis: protease-dependent activation of cell shrinkage and DNA degradation
1998 · Francis M. Hughes, John A. Cidlowski · The Journal of Steroid Biochemistry and Molecular Biology · 57
Staphylococcus aureusandSalmonella entericaSerovar Dublin Induce Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Expression by Normal Mouse and Human Osteoblasts
2001 · Emily H. Alexander, Jennifer L. Bento, et al. · Infection and Immunity · 55
Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1β
2017 · Francis M. Hughes, Stephanie J. Sexton, et al. · American Journal of Physiology-Renal Physiology · 51
Evidence that non-caspase proteases are required for chromatin degradation during apoptosis
1998 · Francis M Hughes Jr, Rosemary B Evans-Storms, et al. · Cell Death and Differentiation · 46
Works count: 115
Citation count: 4,759
H-index: 32
I10-index: 68
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