Author

Ethan O. Perlstein

Observed names: E. O. Perlstein, E.O. Perlstein, Ethan O Perlstein, Ethan Perlstein, PERLSTEIN, ETHAN, Perlstein, Ethan, Perlstein, Ethan O, Perlstein, Ethan O.

Observed institutions: Broad Institute, Howard Hughes Medical Institute, Harvard University, National Academies of Sciences, Engineering, and Medicine, Princeton University, National Research Council, National Research Council, Massachusetts Institute of Technology

ORCID: 0000-0002-4734-4391

Observed ORCID: 0000-0002-4734-4391

OpenAlex ID: A5006748871

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models

2007 · Sovan Sarkar, Ethan O Perlstein, et al. · Nature Chemical Biology · 596

Global nucleosome occupancy in yeast

2004 · Bradley E Bernstein, Chih Long Liu, et al. · Genome biology · 356

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A Library of Spirooxindoles Based on a Stereoselective Three-Component Coupling Reaction

2004 · Michael M.-C. Lo, Christopher S. Neumann, et al. · Journal of the American Chemical Society · 276

Small Molecule Enhancers of Rapamycin-Induced TOR Inhibition Promote Autophagy, Reduce Toxicity in Huntington’s Disease Models and Enhance Killing of Mycobacteria by Macrophages

2007 · R. Andres Floto, Sovan Sarkar, et al. · Autophagy · 158

Genetic basis of individual differences in the response to small-molecule drugs in yeast

2007 · Ethan O Perlstein, Douglas M Ruderfer, et al. · Nature Genetics · 123

Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway

2006 · Rebecca A Butcher, Bhupinder S Bhullar, et al. · Nature Chemical Biology · 99

Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG

2019 · Sangeetha Iyer, Feba S. Sam, et al. · Disease Models & Mechanisms · 92

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Sorbitol Is a Severity Biomarker for PMM2‐CDG with Therapeutic Implications

2021 · Anna N. Ligezka, Silvia Radenkovic, et al. · Annals of Neurology · 59

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The Antidepressant Sertraline Targets Intracellular Vesiculogenic Membranes in Yeast

2010 · Meredith M Rainey, Daniel Korostyshevsky, et al. · Genetics · 56

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Ten Simple Rules of Live Tweeting at Scientific Conferences

2014 · Sean Ekins, Ethan O. Perlstein · PLoS Computational Biology · 55

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Harnessing gene expression to identify the genetic basis of drug resistance

2009 · Bo‐Juen Chen, Helen C Causton, et al. · Molecular Systems Biology · 53

Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit

2022 · John P. Vaughen, Emma Theisen, et al. · Neuron · 46

Revealing Complex Traits with Small Molecules and Naturally Recombinant Yeast Strains

2006 · Ethan O. Perlstein, Douglas M. Ruderfer, et al. · Chemistry & Biology · 42

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Accumulation of an Antidepressant in Vesiculogenic Membranes of Yeast Cells Triggers Autophagy

2012 · Jingqiu Chen, Daniel Korostyshevsky, et al. · PLoS ONE · 37

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Defects in the Neuroendocrine Axis Contribute to Global Development Delay in a Drosophila Model of NGLY1 Deficiency

2018 · Tamy Portillo Rodriguez, Joshua D Mast, et al. · G3 Genes Genomes Genetics · 36

Display of functional αβ single-chain T-cell receptor molecules on the surface of bacteriophage

1998 · Jon A Weidanz, Kimberlyn F Card, et al. · Journal of Immunological Methods · 31

Drug screens of NGLY1 Deficiency worm and fly models reveal catecholamine, NRF2 and anti-inflammatory pathway activation as potential clinical approaches

2019 · Sangeetha Iyer, Joshua D. Mast, et al. · Disease Models & Mechanisms · 27

Yeast Models of Phosphomannomutase 2 Deficiency, a Congenital Disorder of Glycosylation

2018 · Jessica P. Lao, Nina DiPrimio, et al. · G3 Genes Genomes Genetics · 22

Systematic Review: Drug Repositioning for Congenital Disorders of Glycosylation (CDG)

2022 · Sandra Brasil, Mariateresa Allocca, et al. · International Journal of Molecular Sciences · 20

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Anatomy of the Crowd4Discovery crowdfunding campaign

2013 · Ethan O Perlstein · SpringerPlus · 17

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Evolutionary rescue of phosphomannomutase deficiency in yeast models of human disease

2022 · Ryan C. Vignogna, Mariateresa Allocca, et al. · eLife · 15

Proceedings of the fifth international RASopathies symposium: When development and cancer intersect

2018 · Katherine A. Rauen, Lisa Schoyer, et al. · American Journal of Medical Genetics Part A · 15

Using Expression and Genotype to Predict Drug Response in Yeast

2009 · Douglas M. Ruderfer, David C. Roberts, et al. · PLoS ONE · 15

Evolutionarily Conserved Optimization of Amino Acid Biosynthesis

2007 · Ethan O. Perlstein, Benjamin L. de Bivort, et al. · Journal of Molecular Evolution · 14

Amino Acid Metabolic Origin as an Evolutionary Influence on Protein Sequence in Yeast

2009 · Benjamin L. de Bivort, Ethan O. Perlstein, et al. · Journal of Molecular Evolution · 13

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Works count: 158

Citation count: 2,345

H-index: 19

I10-index: 28