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Heike J. Wobst

Observed names: Heike J Wobst, Heike Wobst, Wobst, Heike Julia
ORCID: 0000-0002-9041-3241
Observed ORCID: 0000-0002-9041-3241
OpenAlex ID: A5006937919
EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity
2010 · Jan Bieschke, Jenny Russ, et al. · Proceedings of the National Academy of Sciences · 1,050
A Decade of FDA-Approved Drugs (2010–2019): Trends and Future Directions
2021 · Dean G. Brown, Heike J. Wobst · Journal of Medicinal Chemistry · 340
The green tea polyphenol (−)‐epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios
2014 · Heike J. Wobst, Apurwa Sharma, et al. · FEBS Letters · 207
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Clinical development times for innovative drugs
2021 · Dean G. Brown, Heike J. Wobst, et al. · Nature Reviews Drug Discovery · 200
The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future
2020 · Heike J. Wobst, Korrie L. Mack, et al. · Medicinal Research Reviews · 90
Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function
2019 · Yvonne E. Moore, Leslie C. Conway, et al. · Frontiers in Molecular Neuroscience · 58
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The small molecule CLP257 does not modify activity of the K+–Cl− co-transporter KCC2 but does potentiate GABAA receptor activity
2017 · Ross A Cardarelli, Karen Jones, et al. · Nature Medicine · 56
Emerging small-molecule therapeutic approaches for amyotrophic lateral sclerosis and frontotemporal dementia
2019 · Dean G. Brown, James Shorter, et al. · Bioorganic & Medicinal Chemistry Letters · 53
Opportunities and Challenges in Phenotypic Screening for Neurodegenerative Disease Research
2019 · Dean G. Brown, Heike J. Wobst · Journal of Medicinal Chemistry · 47
Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy
2025 · Mari Aikio, Hana M. Odeh, et al. · Cell Reports · 34
Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant
2017 · Heike J. Wobst, Louise Delsing, et al. · PLoS ONE · 29
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Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells
2019 · Jayashree Chadchankar, Victoria Korboukh, et al. · PLoS ONE · 28
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Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro
2017 · Heike J. Wobst, Steven S. Wesolowski, et al. · Frontiers in Molecular Neuroscience · 27
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Increased 4R tau expression and behavioural changes in a novel MAPT-N296H genomic mouse model of tauopathy
2017 · Heike J. Wobst, Franziska Denk, et al. · Scientific Reports · 20
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SLC6A19 inhibition facilitates urinary neutral amino acid excretion and lowers plasma phenylalanine
2024 · Heike J. Wobst, Andreu Viader, et al. · JCI Insight · 19
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Identification of a Core Amino Acid Motif within the α Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures
2019 · Anna J. Nathanson, Yihui Zhang, et al. · Cell Reports · 19
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Promiscuity of in Vitro Secondary Pharmacology Assays and Implications for Lead Optimization Strategies
2019 · Dean G. Brown, Graham F. Smith, et al. · Journal of Medicinal Chemistry · 18
Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau−/− mice
2017 · Mariana Vargas-Caballero, Franziska Denk, et al. · Frontiers in Neuroscience · 17
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Analysis of orphan designation status for FDA approved drugs, and case studies in oncology, neuroscience and metabolic diseases
2023 · Dean G. Brown, Heike J. Wobst · Bioorganic & Medicinal Chemistry · 8
A Small Molecule Slc6a19 Inhibitor Increases Urinary Phenylalanine Excretion and Reduces Its Pathogenic Plasma Accumulation in a Phenylketonuria Mouse Model
2023 · Heike Wobst, Ryan Hollibaugh, et al. · Molecular Genetics and Metabolism · 5
Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy
2025 · Mari Aikio, Hana M. Odeh, et al. · Cell Reports · 4
JNT-517, a first-in-class SLC6A19 inhibitor for the treatment of phenylketonuria, enhances urinary excretion of phenylalanine in healthy volunteers
2024 · Andreu Viader, John Throup, et al. · Molecular Genetics and Metabolism · 2
A survey of the clinical pipeline in neuroscience
2021 · Dean G. Brown, Heike J. Wobst · Bioorganic & Medicinal Chemistry Letters · 1
Effects of acute inhibition of solute carrier family 6 member 19 on plasma and brain amino acid levels and on neurotransmitters in a mouse model of phenylketonuria
2026 · Heike Wobst, Ryan Philbin, et al. · Molecular Genetics and Metabolism
Abstract 4015 RAPID – Photoaffinity-based High-throughput Ligand Discovery in Cells
2026 · Justin Rettenmaier, Matthew Labenski, et al. · Journal of Biological Chemistry
Works count: 28
Citation count: 2,331
H-index: 17
I10-index: 18
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