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Mark A. Graham

Observed names: Graham, M.A., Graham, Mark A., M. A. Graham, M.A. Graham, Mark A Graham, Mark Graham
ORCID: 0000-0001-7186-9107
Observed ORCID: 0000-0001-7186-9107
OpenAlex ID: A5007555526
Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes
2017 · James R. Smith, Beatrice S. L. Collins, et al. · Journal of the American Chemical Society · 141
An Investigation into the Tether Length and Substitution Pattern of Arene-Substituted Complexes for Asymmetric Transfer Hydrogenation of Ketones
2007 · Fung K. Cheung, Changxue Lin, et al. · Organic Letters · 129
Preclinical safety testing of monoclonal antibodies: the significance of species relevance
2007 · Kathryn Chapman, Nick Pullen, et al. · Nature Reviews Drug Discovery · 121
Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2
2015 · Richard A. Ward, Nicola Colclough, et al. · Journal of Medicinal Chemistry · 102
Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153)
2016 · Robert H. Bradbury, Rowena Callis, et al. · Journal of Medicinal Chemistry · 87
The importance of the N–H bond in Ru/TsDPEN complexes for asymmetric transfer hydrogenation of ketones and imines
2011 · Rina Soni, Fung Kei Cheung, et al. · Organic & Biomolecular Chemistry · 83
Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC)
2019 · Richard A. Ward, Mark J. Anderton, et al. · Journal of Medicinal Chemistry · 82
Kinetic and structural studies on ‘tethered’ Ru(ii) arene ketone reduction catalysts
2009 · Fung Kei (Kathy) Cheung, Adam J. Clarke, et al. · Dalton Transactions · 58
Development and Proof of Concept for a Large-Scale Photoredox Additive-Free Minisci Reaction
2020 · Mark A. Graham, Gary Noonan, et al. · Organic Process Research & Development · 55
Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point
2017 · Richard A. Ward, Paul Bethel, et al. · Journal of Medicinal Chemistry · 52
The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing
2008 · Clifford D. Jones, David M. Andrews, et al. · Bioorganic & Medicinal Chemistry Letters · 43
Development and Scale-Up of an Improved Manufacturing Route to the ATR Inhibitor Ceralasertib
2020 · Mark A. Graham, Hannah Askey, et al. · Organic Process Research & Development · 39
Tandem cationic cyclisation–aziridinium ion formation–nucleophilic ring opening: new methodology for the stereocontrolled synthesis of substituted pyrrolidines
2001 · Mark A. Graham, Mark Thornton-Pett, et al. · Chemical Communications · 38
Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode
2008 · M. Raymond V. Finlay, David G. Acton, et al. · Bioorganic & Medicinal Chemistry Letters · 34
Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor
2012 · M. Raymond V. Finlay, David Buttar, et al. · Bioorganic & Medicinal Chemistry Letters · 33
Discovery and Optimization of a Novel Series of Dyrk1B Kinase Inhibitors To Explore a MEK Resistance Hypothesis
2015 · Jason G. Kettle, Peter Ballard, et al. · Journal of Medicinal Chemistry · 32
Synthesis of Functionalized Cyanopyrazoles via Magnesium Bases
2014 · Allan Dishington, J. Lyman Feron, et al. · Organic Letters · 18
“Ether-Linked” Organometallic Catalysts for Ketone Reduction Reactions
2007 · Fung Kei Cheung, Mark A. Graham, et al. · Organometallics · 16
Design and campaign synthesis of pyridine-based histone deacetylase inhibitors
2008 · David M. Andrews, Keith M. Gibson, et al. · Bioorganic & Medicinal Chemistry Letters · 11
Studies on the Lewis acid mediated cleavage of α-aminoacetals: synthesis of novel 1,2-aminoethers, and evidence for α-alkoxy aziridinium ion intermediatesElectronic supplementary information (ESI) available: correlation of 1H NMR spectra between the syn and anti diastereomeric series. See http://www.rsc.org/suppdata/ob/b2/b210116e/
2003 · Mark A. Graham, Alan H. Wadsworth, et al. · Organic & Biomolecular Chemistry · 11
Flexible and Scalable Route to HDAc Inhibitors Containing an Unusual Trisubstituted Pyridine Core
2012 · Mark A. Graham, Steven A. Raw, et al. · Organic Process Research & Development · 9
Unexpected ring-expansion of 1,2-benzisoxazol-3-ones
2011 · Steven A. Raw, Anne M. O’Kearney-McMullan, et al. · Tetrahedron Letters · 8
Novel and Versatile Synthesis of Disubstituted 1,2-Dihydro-1,2,4-triazol-3-ones
2013 · Mark A. Graham, Paul A. Bethel, et al. · Organic Letters · 7
Mechanistic and stereochemical aspects of the Lewis acid mediated cleavage of α-aminoacetals
2001 · Mark A Graham, Alan H Wadsworth, et al. · Tetrahedron Letters · 5
Modular synthesis of cyclic β-difluoroamines
2024 · Natalie G. Charlesworth, Dhanarajan Arunprasath, et al. · Chemical Communications · 4
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Works count: 79
Citation count: 1,225
H-index: 17
I10-index: 20
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