Author

Nedim Özdemir

Observed names: N. Ozdemir, N. ÖZDEMİR, N.N.Ozdemir, N.Ozdemir, NEDİM ÖZDEMİR, Nedim Özdemir, Nedim Özdemir, Nedim Ozdemir, Nedim ÖZDEMİR, Ozdemir, Nedim, Ozdemir, Nedim, ÖZDEMİR, NEDİM, Özdemir, N., Özdemir, Nedim, Недим Оздемир, Оздемир, Недим
Institution: Muğla University
Observed institution: Muğla University
ORCID: 0000-0001-7410-6113
Observed ORCID: 0000-0001-7410-6113
OpenAlex ID: A5007750458
2005 · Fevzi Yılmaz, Nedim Özdemir, et al. · Food Chemistry · 399
2012 · A. S. TARKAN, G. H. COPP, et al. · Fisheries Management and Ecology · 74
2006 · A. Levent Tuna, F. Yilmaz, et al. · Environmental Monitoring and Assessment · 49
2006 · Fevzi Yılmaz, Murat Barlas, et al. · DOAJ (DOAJ: Directory of Open Access Journals) · 16
2021 · Ahmet Demirak, Feyyaz Keskin, et al. · Environmental Science and Pollution Research · 13
2015 · Nedim Özdemir, Ali Serhan Tarkan, et al. · Çanakkale Onsekiz Mart University AVESIS · 12
2023 · CENGİZ ÇESKO, SAMİ GASHİ, et al. · TURKISH JOURNAL OF AGRICULTURE AND FORESTRY · 8
2024 · Mustafa Döndü, Nedim Özdemir, et al. · Regional Studies in Marine Science · 7
2021 · Hasan Cerim, Nedim Özdemir, et al. · Regional Studies in Marine Science · 7
2014 · Nedim Özdemir, Ahmet Demirak, et al. · Environmental Monitoring and Assessment · 7
2022 · Nedim ÖZDEMİR, Mesut PERKTAŞ, et al. · Adnan Menderes Üniversitesi Ziraat Fakültesi Dergisi · 5
2007 · Nedim Özdemir, Fevzi Yılmaz, et al. · Muğla Sıtkı Koçman University Institutional Repository · 5
2019 · Yıldırım Bayazit, Recep Bakiş, et al. · Journal of Geoscience and Environment Protection · 4
2019 · Mustafa DÖNDÜ, Nedim ÖZDEMİR · Adnan Menderes Üniversitesi Ziraat Fakültesi Dergisi · 2
Impact of select Polyphenols on α-amylase Activity under In vitro Conditions Khasan Y. Kayumov1*, Lubov S. Kuchkarova1, Jakhongir S. Abdurakhmonov1, Rashidbek Kh. Achilov1, Shoaib Khan2, Teodoro Durá-Travé3, Manzura A. Agzamova4, Komila A. Eshbakova4, Shohista O. Meliyeva4, Nedim Özdemir5, Anum Masood6 1National University of Uzbekistan named after Mirza Ulugbek, Tashkent, Uzbekistan. 2Department of Chemistry, Abbottabad University of Science and Technology, Abbottabad - 22500, Pakistan. 3Faculty of Medicine, University of Navarra, Spain. 4Institute of Chemistry of Plant Substans of the Academy of Sciences of Uzbekistan, Tashkent, Uzbekistan. 5Mugla Sıtkı Kocman University, Turkey. 6Department of Pharmaceutical Chemistry, The Islamia University of Bahawalpur Pakistan, Bahawalpur, Pakistan. *Corresponding Author E-mail: [email protected] ABSTRACT: Background: Flavonoids have been extensively researched for their ability to modulate enzyme activity, particularly in relation to controlling blood sugar and carbohydrates metabolism. However, there is limited information on the tissue-specific effects of structurally diverse flavonoids on α-amylase activity. This study aimed to investigate and compare rutin, quercetin, luteolin, chrysosplenetin, and thamiflaside affects on α-amylase activity in various parts of the digestive system. Methods: We used homogenates from pancreatic tissue, parotid gland, intestinal mucosa, and chyme during in vitro assays. Flavonoids were tested at different levels and α-amylase activity was measured using a spectrophotometer. The Student-Fisher t-test was used to run a statistical analysis to determine dose and tissue-dependent effects. Results: Rutin, quercetin, luteolin, and chrysosplenetin significantly and dose-dependently inhibited the α-amylase activity. The parotid gland and intestinal mucosa were more sensitive (p<0.05). Luteolin had the strongest inhibitory impact, perhaps because of its hydroxylation patterns. On the other hand, thamiflaside had a distinct influence on α-amylase activity, particularly in the salivary and intestinal compartments suggesting allosteric activation pathways. The varied modulatory profiles were correlated with flavonoid structure-function relationships, where the distribution of hydroxyl and methoxyl groups determines the enzyme binding and outcomes. Conclusion: The results showed that some flavonoids might be used as natural α-amylase inhibitors to regulate blood sugar levels and treat metabolic disorders. They also showed that thamiflaside could help those who need better carbohydrate digestion. These findings revealed that flavonoids might be added to nutraceutical formulations in an organized way. Furthermore, in vivo and clinical studies are needed to determine their safety and efficacy as therapeutic agents. KEYWORDS: Flavonoids, α-Amylase, Rutin, Quercetin, Luteolin, Chrysosplenetin, Thamiflaside, Enzyme Modulation, Glycemic Control, Digestive Enzymes.
2025 · Khasan Y. Kayumov, Lubov S. Kuchkarova, et al. · Research Journal of Pharmacy and Technology · 1
2022 · Keskin, Feyyaz, Demirak, Ahmet, et al. · Journal of international environmental application and science · 1
2019 · Cengiz Koç, Nedim Özdemir · European Journal of Science and Technology · 1
2006 · Nedim Özdemir, Seher Dirican · DOAJ (DOAJ: Directory of Open Access Journals) · 1
Works count: 48
Citation count: 1,206
H-index: 10
I10-index: 10
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