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Gemma Mudd

Observed names: G Mudd, Gemma E Mudd, Gemma E. Mudd, Mudd, Gemma E.
ORCID: 0000-0002-5075-1625
Observed ORCID: 0000-0002-5075-1625
OpenAlex ID: A5008373586
Discovery of BT8009: A Nectin-4 Targeting Bicycle Toxin Conjugate for the Treatment of Cancer
2022 · Gemma E. Mudd, Heather Scott, et al. · Journal of Medicinal Chemistry · 111
MMAE Delivery Using the Bicycle Toxin Conjugate BT5528
2020 · Gavin Bennett, Amy Brown, et al. · Molecular Cancer Therapeutics · 106
BT8009; A Nectin-4 Targeting Bicycle Toxin Conjugate for Treatment of Solid Tumors
2022 · Michael Rigby, Gavin Bennett, et al. · Molecular Cancer Therapeutics · 85
Identification and Optimization of EphA2-Selective Bicycles for the Delivery of Cytotoxic Payloads
2020 · Gemma E. Mudd, Amy Brown, et al. · Journal of Medicinal Chemistry · 80
Bicyclic Peptides as a New Modality for Imaging and Targeting of Proteins Overexpressed by Tumors
2019 · Matthias Eder, Silvia Pavan, et al. · Cancer Research · 70
Comprehensive Surfaceome Profiling to Identify and Validate Novel Cell-Surface Targets in Osteosarcoma
2022 · Yifei Wang, Xiangjun Tian, et al. · Molecular Cancer Therapeutics · 41
Complementary Benzophenone Cross-Linking/Mass Spectrometry Photochemistry
2017 · Adam Belsom, Gemma Mudd, et al. · Analytical Chemistry · 33
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Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist
2021 · Punit Upadhyaya, Johanna Lahdenranta, et al. · Journal for ImmunoTherapy of Cancer · 32
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A general synthetic route to isomerically pure functionalized rhodamine dyes
2015 · Gemma Mudd, Irene Pérez Pi, et al. · Methods and Applications in Fluorescence · 27
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Development and preclinical characterization of a novel radiotheranostic EphA2-targeting bicyclic peptide
2024 · Mohamed El Fakiri, Anusha R. Regupathy, et al. · Theranostics · 26
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Discovery and Optimization of a Synthetic Class of Nectin-4-Targeted CD137 Agonists for Immuno-oncology
2022 · Punit Upadhyaya, Julia Kristensson, et al. · Journal of Medicinal Chemistry · 21
Gold-Mediated Multiple Cysteine Arylation for the Construction of Highly Constrained Bicycle Peptides
2022 · Gemma E. Mudd, Steven J. Stanway, et al. · Bioconjugate Chemistry · 16
Identification and X‐ray Co‐crystal Structure of a Small‐Molecule Activator of LFA‐1‐ICAM‐1 Binding
2014 · Martin Hintersteiner, Jörg Kallen, et al. · Angewandte Chemie International Edition · 14
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Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin
2024 · Frank Narjes, Fredrik Edfeldt, et al. · Journal of Medicinal Chemistry · 9
Abstract C061: BT8009, a Bicycle Toxin Conjugate targeting Nectin-4, shows target selectivity, and efficacy in preclinical large and small tumor models
2019 · Michael Rigby, Gavin Bennett, et al. · Molecular Cancer Therapeutics · 9
Towards mimicking short linear peptide motifs: identification of new mixed α,β-peptidomimetic ligands for SLAM-Associated Protein (SAP) by confocal on-bead screening
2012 · Martin Hintersteiner, Andrew J. Knox, et al. · Journal of Chemical Biology · 8
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Design of Bicyclic Peptide Tandems Mimicking the Homodimeric GDF15 Protein to Inhibit GDF15–GFRaL–RET Complex Cell Signaling
2025 · Anaïs F. M. Noisier, Jenny Sandmark, et al. · Journal of Medicinal Chemistry · 6
Abstract 4479: BT8009: A bicyclic peptide toxin conjugate targeting Nectin-4 (PVRL4) displays efficacy in preclinical tumor models
2019 · Mike Rigby, Paul Beswick, et al. · Cancer Research · 6
Unlocking the potential of EphA2 with precision-guided cancer therapy: bicycle drug conjugates
2026 · Gavin Bennett, Jitka Riedl, et al. · Journal of Translational Medicine · 4
Abstract 5854: BT5528, a Bicycle Toxin Conjugate targeting EphA2 has potent anti-tumor activity without bleeding or coagulation abnormalities in preclinical models
2018 · Gavin Bennett, Philip Huxley, et al. · Cancer Research · 3
Abstract 5807: Bicycle Toxin Conjugates®for the treatment of solid tumors
2024 · Stephen J. Walsh, Johanna Lahdenranta, et al. · Cancer Research · 2
Abstract 1319: Rapid accumulation of cytotoxic payload in tumor tissue drives BT5528 activity in tumor models
2021 · Johanna Lahdenranta, Gavin Bennett, et al. · Cancer Research · 2
Abstract C066: BT5528, a Bicycle Toxin Conjugate targeting EphA2: mechanism of action and clinical translation
2019 · Gavin Bennett, Amy Brown, et al. · Molecular Cancer Therapeutics · 2
Abstract 4481: BT5528, an EphA2-targeting Bicycle Toxin Conjugate (BTC): Profound efficacy without bleeding and coagulation abnormalities in animal models
2019 · Gavin S. Bennett, Amy Brown, et al. · Cancer Research · 2
Abstract 5855: Bicycle Drug Conjugates targeting EphA2 for the treatment of solid tumors: Discovery and selection of BT5528
2018 · Gavin Bennett, Philip Huxley, et al. · Cancer Research · 2
Works count: 73
Citation count: 721
H-index: 13
I10-index: 13
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