Get started
Author

Brian Elenbaas

Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain
1996 · Paul H. Kussie, Svetlana Gorina, et al. · Science · 2,239
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
2001 · Brian Elenbaas, Lisa Spirio, et al. · Genes & Development · 888
PDF
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.
1994 · J Lin, J Chen, et al. · Genes & Development · 656
PDF
Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation
2002 · William C. Hahn, Scott K. Dessain, et al. · Molecular and Cellular Biology · 626
Heterotypic Signaling between Epithelial Tumor Cells and Fibroblasts in Carcinoma Formation
2001 · Brian Elenbaas, Robert A. Weinberg · Experimental Cell Research · 572
p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches
1995 · Suman Lee, Brian Elenbaas, et al. · Cell · 409
PDF
The Ribosomal L5 Protein Is Associated with mdm-2 and mdm-2-p53 Complexes
1994 · V Marechal, B Elenbaas, et al. · Molecular and Cellular Biology · 324
Immortalization and transformation of primary human airway epithelial cells by gene transfer
2002 · Ante S Lundberg, Scott H Randell, et al. · Oncogene · 261
Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress
2021 · Anish Thomas, Nobuyuki Takahashi, et al. · Cancer Cell · 174
PDF
The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain
1996 · Brian Elenbaas, Matthias Dobbelstein, et al. · Molecular Medicine · 166
PDF
Identification of SFRP1 as a Candidate Mediator of Stromal-to-Epithelial Signaling in Prostate Cancer
2005 · Margaret S. Joesting, Steve Perrin, et al. · Cancer Research · 160
PDF
Alternatively Spliced Forms in the Carboxy-Terminal Domain of the p53 Protein Regulate Its Ability to Promote Annealing of Complementary Single Strands of Nucleic Acids
1995 · Lin Wu, J. Henri Bayle, et al. · Molecular and Cellular Biology · 108
PDF
The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity.
1995 · J H Bayle, B Elenbaas, et al. · Proceedings of the National Academy of Sciences · 102
MEK inhibition leads to BRCA2 downregulation and sensitization to DNA damaging agents in pancreas and ovarian cancer models
2018 · Francesca Vena, Ruochen Jia, et al. · Oncotarget · 49
PDF
Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis
1997 · Vincent Marechal, Brian Elenbaas, et al. · Oncogene · 43
Selective Inhibition of ATM-dependent Double-strand Break Repair and Checkpoint Control Synergistically Enhances the Efficacy of ATR Inhibitors
2023 · Audrey Turchick, Astrid Zimmermann, et al. · Molecular Cancer Therapeutics · 30
PDF
Structure-based design of low-nanomolar PIM kinase inhibitors
2014 · Alexey Ishchenko, Lin Zhang, et al. · Bioorganic & Medicinal Chemistry Letters · 30
ATR inhibition augments the efficacy of lurbinectedin in small‐cell lung cancer
2023 · Christopher W Schultz, Yang Zhang, et al. · EMBO Molecular Medicine · 29
PDF
Two upstream elements activate transcription of a major histocompatibility complex class I genein vitro
1992 · Paul H. Driggers, Brian A. Elenbaas, et al. · Nucleic Acids Research · 26
Abstract 369: Antitumor activity of M4344, a potent and selective ATR inhibitor, in monotherapy and combination therapy
2019 · Frank T. Zenke, Astrid Zimmermann, et al. · Cancer Research · 23
Relationship among DDR gene mutations, TMB and PD-L1 in solid tumour genomes identified using clinically actionable biomarker assays
2023 · Danyi Wang, Brian Elenbaas, et al. · npj Precision Oncology · 22
PDF
Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation
2002 · Hahn, William C., Dessain, Scott K., et al. · Molecular and Cellular Biology · 17
PDF
p70S6K/Akt dual inhibitor DIACC3010 is efficacious in preclinical models of gastric cancer alone and in combination with trastuzumab
2023 · Shota Fukuoka, Yoshikatsu Koga, et al. · Scientific Reports · 13
PDF
105 BIIB024, a potent pan-Raf kinase inhibitor for melanoma and solid tumors
2010 · B. Elenbaas, L. Singh, et al. · European Journal of Cancer Supplements · 4
Abstract 369: Antitumor activity of M4344, a potent and selective ATR inhibitor, in monotherapy and combination therapy
2019 · Frank T. Zenke, Astrid Zimmermann, et al. · Experimental and Molecular Therapeutics · 3
Works count: 51
Citation count: 6,984
H-index: 21
I10-index: 23
Year
Topic
Type