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Laura Iturrino

Discovery of 3-Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor
2012 · Jose María Cid, Gary Tresadern, et al. · Journal of Medicinal Chemistry · 84
Discovery of New Tetracyclic Tetrahydrofuran Derivatives as Potential Broad-Spectrum Psychotropic Agents
2004 · Javier Fernández, José M. Alonso, et al. · Journal of Medicinal Chemistry · 74
Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging
2012 · José-Ignacio Andrés, Jesús Alcázar, et al. · Journal of Medicinal Chemistry · 53
Discovery of a New Series of Centrally Active Tricyclic Isoxazoles Combining Serotonin (5-HT) Reuptake Inhibition with α2-Adrenoceptor Blocking Activity
2004 · J. Ignacio Andrés, Jesús Alcázar, et al. · Journal of Medicinal Chemistry · 51
Discovery of a Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitor for the Potential Treatment of Schizophrenia
2014 · José Manuel Bartolomé-Nebreda, Francisca Delgado, et al. · Journal of Medicinal Chemistry · 45
Synthesis, In Vivo Occupancy, and Radiolabeling of Potent Phosphodiesterase Subtype-10 Inhibitors as Candidates for Positron Emission Tomography Imaging
2011 · José-Ignacio Andrés, Meri De Angelis, et al. · Journal of Medicinal Chemistry · 42
Synthesis and structure–activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT2A/2C receptor antagonists. Part 1
2002 · J.Ignacio Andrés, Jesús Alcázar, et al. · Bioorganic & Medicinal Chemistry Letters · 42
Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM)
2016 · Jose María Cid, Gary Tresadern, et al. · Journal of Medicinal Chemistry · 41
Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer
2019 · Frederik J. R. Rombouts, Lieven Declercq, et al. · Journal of Medicinal Chemistry · 35
NMR investigations of protein–carbohydrate interactions: insights into the topology of the bound conformation of a lactose isomer and β-galactosyl xyloses to mistletoe lectin and galectin-1
2001 · José Manuel Alonso-Plaza, Marı́a Angeles Canales, et al. · Biochimica et Biophysica Acta (BBA) - General Subjects · 32
Novel Approach for Chemotype Hopping Based on Annotated Databases of Chemically Feasible Fragments and a Prospective Case Study: New Melanin Concentrating Hormone Antagonists
2009 · Julen Oyarzabal, Trevor Howe, et al. · Journal of Medicinal Chemistry · 30
Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors
2002 · J.Ignacio Andrés, José M Alonso, et al. · Bioorganic & Medicinal Chemistry Letters · 29
Synthesis of 2-N,N-Dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo-[b,f]furo[2,3-d]oxepin Derivatives as Potential Anxiolytic Agents
2004 · Andrés Avelino Trabanco, José Manuel Alonso, et al. · Chemical and Pharmaceutical Bulletin · 28
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Dihydrothiazolopyridone Derivatives as a Novel Family of Positive Allosteric Modulators of the Metabotropic Glutamate 5 (mGlu5) Receptor
2013 · José Manuel Bartolomé-Nebreda, Susana Conde-Ceide, et al. · Journal of Medicinal Chemistry · 24
Synthesis, cytostatic and trichomonacide activities of 3,5-bis-(halomethyl)pyrazoles
1987 · Laura Iturrino, Pilar Navarro, et al. · European Journal of Medicinal Chemistry · 23
Synthesis of 7-amino-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazole derivatives displaying combined α2-adrenoceptor antagonistic and 5-HT reuptake inhibiting activities
2006 · J. Ignacio Andrés, Jesús Alcázar, et al. · Bioorganic & Medicinal Chemistry · 20
Synthesis and structure–activity relationship of 2-(aminoalkyl)-3,3a,8,12b-tetrahydro-2H-dibenzocyclohepta[1,2-b]furan derivatives: a novel series of 5-HT2A/2C receptor antagonists
2004 · José Cid, José M. Alonso, et al. · Bioorganic & Medicinal Chemistry Letters · 18
Synthesis of 3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles, displaying combined 5-HT uptake inhibiting and α2-adrenoceptor antagonistic activities. Part 2: Further exploration on the cinnamyl moiety
2004 · Joaquı́n Pastor, Jesús Alcázar, et al. · Bioorganic & Medicinal Chemistry Letters · 18
2-(Dimethylaminomethyl)-tetrahydroisoxazolopyridobenzazepine derivatives. Synthesis of a new 5-HT2C antagonist with potential anxiolytic properties
2002 · J.Ignacio Andrés, José M. Alonso, et al. · Bioorganic & Medicinal Chemistry Letters · 17
Synthesis of novel 3-substituted-2,3-dihydro-1,4-dioxino[2,3-b]pyridines as potential new scaffolds for drug discovery: selective introduction of substituents on the pyridine ring
2003 · Jesús Alcázar, José M. Alonso, et al. · Tetrahedron Letters · 10
Automated open-access liquid chromatography high resolution mass spectrometry to support drug discovery projects
2019 · Alberto Fontana, Laura Iturrino, et al. · Journal of Pharmaceutical and Biomedical Analysis · 8
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Orthogonal analytical screening for liquid chromatography–mass spectrometry method development and preparative scale-up
2010 · Luis M. Font, A. Fontana, et al. · Journal of Chromatography A · 7
4-Phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives, a novel class of selective δ-opioid agonists
2005 · Andrés A. Trabanco, Shirley Pullan, et al. · Bioorganic & Medicinal Chemistry Letters · 7
Synthesis and structure–Activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT2A/2C receptor antagonists. Part 2
2002 · J Ignacio Andrés, Jesús Alcázar, et al. · Bioorganic & Medicinal Chemistry Letters · 7
Correction to Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer
2020 · Frederik J. R. Rombouts, Lieven Declercq, et al. · Journal of Medicinal Chemistry · 1
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Works count: 30
Citation count: 746
H-index: 18
I10-index: 20
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