Author

Ugo Zanelli

Observed names: U Zanelli, U. Zanelli

Observed institutions: Merck KGaA, Darmstadt (Germany), Siena Biotech (Italy), GlaxoSmithKline (Italy), National Research Council, Galderma (Switzerland), Merck Healthcare KGaA, Darmstadt (Germany)

ORCID: 0000-0002-8942-412X

Observed ORCID: 0000-0002-8942-412X

OpenAlex ID: A5009359323

Procognitive and Neuroprotective Activity of a Novel α7 Nicotinic Acetylcholine Receptor Agonist for Treatment of Neurodegenerative and Cognitive Disorders

2009 · Renza Roncarati, Carla Scali, et al. · Journal of Pharmacology and Experimental Therapeutics · 102

Comparison of Cryopreserved HepaRG Cells with Cryopreserved Human Hepatocytes for Prediction of Clearance for 26 Drugs

2011 · Ugo Zanelli, Nicola Pasquale Caradonna, et al. · Drug Metabolism and Disposition · 78

M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 (β5i) Delivering Efficacy in Multiple Myeloma Models

2021 · Michael P. Sanderson, Manja Friese-Hamim, et al. · Molecular Cancer Therapeutics · 40

Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (β5i)

2021 · Markus Klein, Michael Busch, et al. · Journal of Medicinal Chemistry · 38

Comparison of methods for the prediction of human clearance from hepatocyte intrinsic clearance for a set of reference compounds and an external evaluation set

2016 · Tetsuo Yamagata, Ugo Zanelli, et al. · Xenobiotica · 38

Establishing a systematic framework to characterise in vitro methods for human hepatic metabolic clearance

2018 · Varvara Gouliarmou, Alfonso Maria Lostia, et al. · Toxicology in Vitro · 37

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Expression of Tight Junction and Drug Efflux Transporter Proteins in an in vitro Model of Human Blood–Brain Barrier

2012 · Chiara Cioni, Elisa Turlizzi, et al. · Frontiers in Psychiatry · 33

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Fruitful Adrenergic α2C-Agonism/α2A-Antagonism Combination to Prevent and Contrast Morphine Tolerance and Dependence,

2010 · Fabio Del Bello, Laura Mattioli, et al. · Journal of Medicinal Chemistry · 33

Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonists Containing a Urea Moiety: Identification and Characterization of the Potent, Selective, and Orally Efficacious Agonist 1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) Urea (SEN34625/WYE-103914)

2010 · Chiara Ghiron, Simon N. Haydar, et al. · Journal of Medicinal Chemistry · 30

Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: Comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs

2011 · David Hallifax, Elisa Turlizzi, et al. · European Journal of Pharmaceutical Sciences · 26

Induction of peroxisomal β-oxidation and P-450 4A-dependent activities by pivalic and trichloroacetic acid in rat liver and kidney

1996 · U. Zanelli, P. Puccini, et al. · Archives of Toxicology · 22

Structure–activity relationship and properties optimization of a series of Quinazoline-2,4-diones as inhibitors of the canonical Wnt pathway

2015 · Arianna Nencini, Carmela Pratelli, et al. · European Journal of Medicinal Chemistry · 19

Synthesis and toxicity to mammalian cells of the carrot dihydroisocoumarins

1993 · Stefano Superchi, Dario Pini, et al. · Chemical Research in Toxicology · 16

Toxicity of 6-methoxymellein and 6-hydroxymellein to the producing carrot cells

1996 · Flavia Marinelli, Ugo Zanelli, et al. · Phytochemistry · 15

Evaluation of the novel in vitro systems for hepatic drug clearance and assessment of their predictive utility

2012 · J. Brian Houston, Karen Rowland-Yeo, et al. · Toxicology in Vitro · 13

Stabilization of cytochrome P4502E1 protein by ethanol in primary hamster hepatocyte cultures

2000 · U Zanelli, V Longo, et al. · Toxicology in Vitro · 12

Abstract DDT02-01: First-time disclosure of M3258: A selective inhibitor of the immunoproteasome subunit LMP7 with potential for improved therapeutic utility in multiple myeloma compared to pan-proteasome inhibitors

2019 · Michael Sanderson, Michael Busch, et al. · Cancer Research · 9

Determination of low intrinsic clearancein vitro: the benefit of a novel internal standard in human hepatocyte incubations

2018 · Ugo Zanelli, Thomas Michna, et al. · Xenobiotica · 8

Abstract LB-054: Discovery and profiling of M3258, a potent and selective LMP7 inhibitor demonstrating high efficacy in multiple myeloma models

2019 · Markus Klein, Michael Busch, et al. · Cancer Research · 6

Evaluation of the role of intestinal and liver metabolism in the conversion of two different ester prodrugs of sanfetrinem to the parent drug in vitro and in vivo using different rat tissues and a surgically prepared rat model

2002 · Simone Braggio, Alessia Ferrara, et al. · European Journal of Pharmaceutical Sciences · 6

Discovery of a novel series of selective macrocyclic PKCTheta inhibitors

2024 · Stefano Crosignani, Sebastien Campos, et al. · Bioorganic & Medicinal Chemistry Letters · 4

2019 · Michael Sanderson, Michael Busch, et al. · Molecular and Cellular Biology / Genetics · 2

Abstract LB-054: Discovery and profiling of M3258, a potent and selective LMP7 inhibitor demonstrating high efficacy in multiple myeloma models

2019 · Markus Klein, Michael Busch, et al. · Cancer Chemistry · 2

Building In Silico Models to Trigger Retesting: A Strategy on How to Use Predictive Models to Identify Potentially Incorrect In Vitro Intrinsic Clearance Results

2018 · Fabian Pitter Steinmetz, Carl Petersson, et al. · Applied In Vitro Toxicology · 2

Selective Depletion of Mitochondrial Glutathione Content by Pivalic Acid and Valproic Acid in Rat Liver

1996 · U. Zanelli, P. Puccini, et al. · Advances in experimental medicine and biology · 2

Works count: 31

Citation count: 595

H-index: 14

I10-index: 16