Get started
Author

Gregory Caleb Howard

Observed names: G.C. Howard, Gregory C Howard, Gregory C. Howard, Gregory C Howard, Gregory C. Howard
ORCID: 0000-0002-8373-4573
Observed ORCID: 0000-0002-8373-4573
OpenAlex ID: A5009481406
Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC
2015 · Lance R. Thomas, Qingguo Wang, et al. · Molecular Cell · 310
PDF
Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity
2019 · Erin R. Aho, Jing Wang, et al. · Cell Reports · 128
PDF
MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1
2021 · Tessa M Popay, Jing Wang, et al. · eLife · 93
Inhibition of MYC by the SMARCB1 tumor suppressor
2019 · April M. Weissmiller, Jing Wang, et al. · Nature Communications · 87
PDF
WDR5 is a conserved regulator of protein synthesis gene expression
2020 · Audra F Bryan, Jing Wang, et al. · Nucleic Acids Research · 84
PDF
Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC
2018 · Lance R. Thomas, Q. Wang, et al. · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · 64
Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models
2022 · Kevin B. Teuscher, Somenath Chowdhury, et al. · Proceedings of the National Academy of Sciences · 41
WIN site inhibition disrupts a subset of WDR5 function
2022 · Andrew J. Siladi, Jing Wang, et al. · Scientific Reports · 37
PDF
Synergistic action of WDR5 and HDM2 inhibitors in SMARCB1-deficient cancer cells
2022 · Andrea C Florian, Chase M Woodley, et al. · NAR Cancer · 19
Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
2023 · Gregory Caleb Howard, Jing Wang, et al. · eLife · 18
PDF
The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B
2014 · Mélanie Bonizec, Lucas Hérissant, et al. · Nucleic Acids Research · 15
PDF
Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies
2024 · Christian T. Meyer, Brianna N. Smith, et al. · Proceedings of the National Academy of Sciences · 13
Ribosome-directed cancer therapies: the tip of the iceberg?
2025 · Gregory C. Howard, William P. Tansey · Trends in Pharmacological Sciences · 9
Letter to the Editor
2011 · Gregory C. Howard, Galen A. Collins, et al. · Yeast · 9
Characterization of osteoblastic properties of 7F2 and UMR-106 cultures after acclimation to reduced levels of fetal bovine serum
2008 · S. Ganguly, L.A. Ashley, et al. · Canadian Journal of Physiology and Pharmacology · 7
Interaction of Gcn4 with target gene chromatin is modulated by proteasome function
2016 · Gregory C. Howard, William P. Tansey · Molecular Biology of the Cell · 4
Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
2023 · Gregory C. Howard, Jing Wang, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
PDF
Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
2024 · Gregory C. Howard, Jing Wang, et al. · eLife · 1
Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
2023 · Gregory C. Howard, Jing Wang, et al. · eLife · 1
PDF
Author response: Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
2024 · Gregory Caleb Howard, Jing Wang, et al. · eLife
Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
2024 · Gregory Caleb Howard, Jing Wang, et al. · eLife
Author response: Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
2024 · Gregory C. Howard, Jing Wang, et al. · eLife
PDF
Author response: MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1
2020 · Tessa M Popay, Jing Wang, et al. · eLife
Abstract LB-206: Inhibition of MYC by the SMARCB1 tumor suppressor
2018 · April M. Weissmiller, Jing Wang, et al. · Cancer Research
Works count: 25
Citation count: 942
H-index: 12
I10-index: 12
Year
Topic
Type