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Laura M. Tsujikawa

Observed names: L M Tsujikawa, L Tsujikawa, L. Tsujikawa, LAURA TSUJIKAWA, Laura M Tsujikawa, Laura Tsujikawa, Tsujikawa, L, Tsujikawa, Laura.
Observed institutions: University of Wisconsin–Madison, University of Alberta, University of Calgary, University of California, Irvine, VA Palo Alto Health Care System, Alberta University of the Arts, Amsterdam UMC Location University of Amsterdam, Resverlogix (Canada), Case Western Reserve University
OpenAlex ID: A5010165450
RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist
2013 · Kevin G. McLure, Emily M. Gesner, et al. · PLoS ONE · 199
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Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism
2019 · Laura M. Tsujikawa, Li Fu, et al. · Clinical Epigenetics · 128
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RVX-208, a BET-inhibitor for treating atherosclerotic cardiovascular disease, raises ApoA-I/HDL and represses pathways that contribute to cardiovascular disease
2016 · Dean Gilham, Sylwia Wasiak, et al. · Atherosclerosis · 117
Different Roles for Basic and Aromatic Amino Acids in Conserved Region 2 of Escherichia coli ς70 in the Nucleation and Maintenance of the Single-stranded DNA Bubble in Open RNA Polymerase-Promoter Complexes
2001 · Mark Tomsic, Laura Tsujikawa, et al. · Journal of Biological Chemistry · 72
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Apabetalone downregulates factors and pathways associated with vascular calcification
2018 · Dean Gilham, Laura M. Tsujikawa, et al. · Atherosclerosis · 65
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Downregulation of the Complement Cascade In Vitro, in Mice and in Patients with Cardiovascular Disease by the BET Protein Inhibitor Apabetalone (RVX-208)
2017 · Sylwia Wasiak, Dean Gilham, et al. · Journal of Cardiovascular Translational Research · 51
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Benefit of Apabetalone on Plasma Proteins in Renal Disease
2017 · Sylwia Wasiak, Laura M. Tsujikawa, et al. · Kidney International Reports · 42
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Interaction of RNA polymerase with forked DNA: Evidence for two kinetically significant intermediates on the pathway to the final complex
2002 · Laura Tsujikawa, Oleg V. Tsodikov, et al. · Proceedings of the National Academy of Sciences · 37
RNA Polymerase Alters the Mobility of an A-Residue Crucial to Polymerase-Induced Melting of Promoter DNA
2002 · Laura Tsujikawa, Michael G. Strainic, et al. · Biochemistry · 30
Epigenetic BET reader inhibitor apabetalone (RVX-208) counters proinflammatory aortic gene expression in a diet induced obesity mouse model and in human endothelial cells
2022 · Sylwia Wasiak, Laura M. Tsujikawa, et al. · Atherosclerosis · 26
Mutational Analysis of Escherichia coli Heat Shock Transcription Factor Sigma 32 Reveals Similarities with Sigma 70 in Recognition of the −35 Promoter Element and Differences in Promoter DNA Melting and −10 Recognition
2005 · Olga V. Kourennaia, Laura Tsujikawa, et al. · Journal of Bacteriology · 19
Data on gene and protein expression changes induced by apabetalone (RVX-208) in ex vivo treated human whole blood and primary hepatocytes
2016 · Sylwia Wasiak, Dean Gilham, et al. · Data in Brief · 17
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Differences in replication of a DNA template containing an ethyl phosphotriester by T4 DNA polymerase and Escherichia coli DNA polymerase I
2003 · L. Tsujikawa · Nucleic Acids Research · 17
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Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro , in Mice and in Patients with Cardiovascular Disease
2020 · Sylwia Wasiak, Dean Gilham, et al. · Cardiovascular Therapeutics · 15
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Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators
2022 · Laura M. Tsujikawa, Olesya A. Kharenko, et al. · Biomedicine & Pharmacotherapy · 13
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Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment
2023 · Dean Gilham, Sylwia Wasiak, et al. · Biomedicines · 12
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Inhibition of epigenetic reader proteins by apabetalone counters inflammation in activated innate immune cells from Fabry disease patients receiving enzyme replacement therapy
2022 · Li Fu, Sylwia Wasiak, et al. · Pharmacology Research & Perspectives · 12
Abstract LB-038: Preclinical development and clinical validation of a whole blood pharmacodynamic marker assay for the BET bromodomain inhibitor ZEN-3694 in metastatic castration-resistant prostate cancer (mCRPC) patients
2017 · Laura Tsujikawa, Karen Norek, et al. · Cancer Research · 9
Abstract LB-207: Preclinical characterization of ZEN-3694, a novel BET bromodomain inhibitor entering phase I studies for metastatic castration-resistant prostate cancer (mCRPC)
2016 · Sarah Attwell, Ravi Jahagirdar, et al. · Cancer Research · 9
Abstract C86: The clinical candidate ZEN-3694, a novel BET bromodomain inhibitor, is efficacious in the treatment of a variety of solid tumor and hematological malignancies, alone or in combination with several standard of care and targeted therapies
2015 · Sarah Attwell, Eric Campeau, et al. · Molecular Cancer Therapeutics · 9
Dual mechanism: Epigenetic inhibitor apabetalone reduces SARS-CoV-2 Delta and Omicron variant spike binding and attenuates SARS-CoV-2 RNA induced inflammation
2023 · Li Fu, Dean Gilham, et al. · International Immunopharmacology · 6
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Corrigendum to “RVX-208, a BET-inhibitor for treating atherosclerotic cardiovascular disease, raises ApoA-I/HDL and represses pathways that contribute to cardiovascular disease” [Atherosclerosis 247 (2016) 48–57]
2016 · Dean Gilham, Sylwia Wasiak, et al. · Atherosclerosis · 5
Probing the Role of Region 2 of Escherichia coli σ70 in Nucleation and Maintenance of the Single-Stranded DNA Bubble in RNA Polymerase-Promoter Open Complexes
2003 · Pieter L. deHaseth, Laura Tsujikawa · Methods in enzymology on CD-ROM/Methods in enzymology · 5
Apabetalone, a Clinical-Stage, Selective BET Inhibitor, Opposes DUX4 Target Gene Expression in Primary Human FSHD Muscle Cells
2023 · Christopher D. Sarsons, Dean Gilham, et al. · Biomedicines · 4
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The BET inhibitor apabetalone decreases neuroendothelial proinflammatory activationin vitroand in a mouse model of systemic inflammation
2023 · Sylwia Wasiak, Li Fu, et al. · Translational Neuroscience · 2
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Works count: 73
Citation count: 938
H-index: 14
I10-index: 17
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