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Mitchell Gulkis

Observed names: Gulkis, Mitchell, M. Gulkis, M.C. Gulkis, Mitchell C. Gulkis
Observed institution: University of Florida
ORCID: 0000-0001-5831-8802
Observed ORCID: 0000-0001-5831-8802
OpenAlex ID: A5010484903
Structures of LIG1 that engage with mutagenic mismatches inserted by polβ in base excision repair
2022 · Qun Tang, Mitchell Gulkis, et al. · Nature Communications · 25
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Unfilled gaps by polβ lead to aberrant ligation by LIG1 at the downstream steps of base excision repair pathway
2024 · Mitchell Gulkis, Ernesto Martinez, et al. · Nucleic Acids Research · 13
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Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA
2024 · Kanal Elamparithi Balu, Mitchell Gulkis, et al. · Journal of Biological Chemistry · 12
Probing the mechanism of nick searching by LIG1 at the single-molecule level
2024 · Surajit Chatterjee, Loïc Chaubet, et al. · Nucleic Acids Research · 7
Impact of polβ/XRCC1 Interaction Variants on the Efficiency of Nick Sealing by DNA Ligase IIIα in the Base Excision Repair Pathway
2023 · Danah Almohdar, Mitchell Gulkis, et al. · Journal of Molecular Biology · 6
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Design, anticancer activity, and mechanistic evaluation of a novel class of selective human carbonic anhydrase IX inhibitors featuring a trifluorodihydroxypropanone pharmacophore
2025 · Nicolino Pala, Federico Ladu, et al. · European Journal of Medicinal Chemistry · 5
Off-target binding of the histone deacetylase inhibitor vorinostat to carbonic anhydrase II and IX
2025 · Mitchell C. Gulkis, James T. Hodgkinson, et al. · Acta Crystallographica Section F Structural Biology Communications · 3
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Structural Characterization of Human Bufavirus 1: Receptor Binding and Endosomal pH-Induced Changes
2024 · Mitchell Gulkis, Mengxiao Luo, et al. · Viruses · 3
Impact of DNA ligase inhibition on the nick sealing of polβ nucleotide insertion products at the downstream steps of base excision repair pathway
2024 · Danah Almohdar, Pradnya Kamble, et al. · Mutagenesis · 3
Molecular editing of NSC-666719 enabling discovery of benzodithiazinedioxide-guanidines as anticancer agents
2024 · Vajja Krishna Rao, Subarno Paul, et al. · RSC Medicinal Chemistry · 1
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AAV2 Crosslinks Actin Filaments: Implications for AAV Gene Therapy Vector Design
2026 · Mitchell Gulkis, James B. Heidings, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Human carbonic anhydrase II in complex with TDP4
2025 · M.C. Gulkis, R. McKenna, et al. · Worldwide Protein Data Bank
Biochemical, structural, and single-molecule characterization of LIG1 active site mutants demonstrate role of F635 and F872 residues for faithful ligation
2024 · Mustafa Kalaycioğlu, Mitchell Gulkis, et al. · bioRxiv (Cold Spring Harbor Laboratory)
Structures of LIG1 active site mutants reveal the importance of DNA end rigidity for mismatch discrimination
2023 · Mitchell Gulkis, Qun Tang, et al. · Research Square
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Abstract 1874: Human DNA ligase I active site mutants demonstrate failure in non-canonical ligation
2023 · Mitchell Gulkis, Qun Tang, et al. · Journal of Biological Chemistry
Structures of LIG1 uncover a lack of sugar discrimination against a ribonucleotide at the 3'-end of nick DNA
2022 · MELIKE CAGLAYAN, Qun Tang, et al. · Research Square
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Structures of LIG1 uncover the mechanism of sugar discrimination against a ribonucleotide at 3’- and 5’-end of the nick DNA
2022 · Qun Tang, Mitchell Gulkis, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Works count: 29
Citation count: 78
H-index: 5
I10-index: 3
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