Author

Joseph Ryan McDermott

Observed names: Joseph McDermott, Joseph Mcdermott, Joseph R. McDermott, McDermott, Joseph Ryan

Observed institutions: Oakland University, Dallas International University, Chinese Academy of Sciences, University of Michigan, Shanghai Institutes for Biological Sciences, Center for Excellence in Molecular Cell Science

ORCID: 0009-0004-6038-3768

Observed ORCID: 0009-0004-6038-3768

OpenAlex ID: A5010789473

Members of rice plasma membrane intrinsic proteins subfamily are involved in arsenite permeability and tolerance in plants

2012 · Kareem A. Mosa, Kundan Kumar, et al. · Transgenic Research · 219

Jen1p: A High Affinity Selenite Transporter in Yeast

2010 · Joseph R. McDermott, Barry P. Rosen, et al. · Molecular Biology of the Cell · 87

A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction

2016 · Lei Hou, Dan Wang, et al. · Cell Metabolism · 68

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Identification of an S-adenosylmethionine (SAM) dependent arsenic methyltransferase in Danio rerio

2012 · Mohamad Hamdi, Masafumi Yoshinaga, et al. · Toxicology and Applied Pharmacology · 47

Trivalent arsenicals and glucose use different translocation pathways in mammalian GLUT1

2009 · Xuan Jiang, Joseph R. McDermott, et al. · Metallomics · 47

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Pentavalent methylated arsenicals are substrates of human AQP9

2009 · Joseph R. McDermott, Xuan Jiang, et al. · BioMetals · 41

Zinc- and bicarbonate-dependent ZIP8 transporter mediates selenite uptake

2016 · Joseph R. McDermott, Xiangrong Geng, et al. · Oncotarget · 37

Formation and activation of thermogenic fat

2015 · Jun Wu, Heejin Jun, et al. · Trends in Genetics · 36

Copper Deficiency in the Lungs of TNF-α Transgenic Mice

2016 · Liu Liu, Xiangrong Geng, et al. · Frontiers in Physiology · 35

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Role of AQP9 in transport of monomethyselenic acid and selenite

2017 · Xiangrong Geng, Joseph McDermott, et al. · BioMetals · 17

Artificial intelligence platform, RADR®, aids in the discovery of DNA damaging agent for the ultra-rare cancer Atypical Teratoid Rhabdoid Tumors

2022 · Joseph McDermott, Drew Sturtevant, et al. · Frontiers in Drug Discovery · 12

Preclinical Efficacy of LP-184, a Tumor Site Activated Synthetic Lethal Therapeutic, in Glioblastoma

2023 · Bachchu Lal, Aditya Kulkarni, et al. · Clinical Cancer Research · 9

A machine learning-based gene signature of response to the novel alkylating agent LP-184 distinguishes its potential tumor indications

2021 · Umesh Kathad, Aditya Kulkarni, et al. · BMC Bioinformatics · 9

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Conditional Dependency of LP-184 on Prostaglandin Reductase 1 is Synthetic Lethal in Pancreatic Cancers with DNA Damage Repair Deficiencies

2023 · Diana Restifo, Joseph R. McDermott, et al. · Molecular Cancer Therapeutics · 7

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The acylfulvene alkylating agent, LP-184, retains nanomolar potency in non-small cell lung cancer carrying otherwise therapy-refractory mutations

2021 · Aditya Kulkarni, Joseph Ryan McDermott, et al. · Oncotarget · 4

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In silico approaches to patient selection: Credentialing elraglusib as a novel treatment in metastatic melanoma resistant to checkpoint inhibitors.

2023 · Joseph McDermott, Taylor Weiskittel, et al. · Journal of Clinical Oncology · 2

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Glioblastoma response to blood-brain-barrier permeable, MGMT-agnostic therapeutic LP-184 and sensitization by nucleotide-excision repair deficiency.

2022 · Joseph McDermott, Bachchu Lal, et al. · Journal of Clinical Oncology · 1

Synthetic lethality of LP-184, a next generation acylfulvene, in ex vivo PDX models with homologous recombination defects.

2021 · Aditya Kulkarni, Diana Restifo, et al. · Journal of Clinical Oncology · 1

Supplementary figures and tables legends from Conditional Dependency of LP-184 on Prostaglandin Reductase 1 is Synthetic Lethal in Pancreatic Cancers with DNA Damage Repair Deficiencies