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Shi‐Ying Cai
Observed names:
Cai, Shi-Ying,
S. -Y. Cai,
S.-Y. Cai,
Shi-Ying Cai,
Shi-ying Cai,
ShiYing Cai,
Shiying Cai,
Shi‐ying Cai,
Shi–Ying Cai
show all 9
Observed institutions:
Mount Desert Island Biological Laboratory,
Southampton General Hospital,
University Hospital Southampton NHS Foundation Trust,
Yale University,
NIHR Southampton Biomedical Research Centre,
University of Southampton
show all 6
ORCID:
0000-0001-6601-4040
Observed ORCID:
0000-0001-6601-4040
OpenAlex ID:
A5010793553
Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTα-OSTβ in cholestasis in humans and rodents
2006
·
James L. Boyer
, Michael Trauner
, et al.
·
American Journal of Physiology-Gastrointestinal and Liver Physiology
·
305
Mechanisms of bile acid mediated inflammation in the liver
2017
·
Man Li
, Shi-Ying Cai
, et al.
·
Molecular Aspects of Medicine
·
272
Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response
2017
·
Shi-Ying Cai
, Xinshou Ouyang
, et al.
·
JCI Insight
·
257
Mrp4−/− mice have an impaired cytoprotective response in obstructive cholestasis
2006
·
Albert Mennone
, Carol J. Soroka
, et al.
·
Hepatology
·
179
PDF
Stat1 as a Component of Tumor Necrosis Factor Alpha Receptor 1-TRADD Signaling Complex To Inhibit NF-κB Activation
2000
·
Yingjian Wang
, Tong R. Wu
, et al.
·
Molecular and Cellular Biology
·
167
The role of bile acids in cholestatic liver injury
2021
·
Shi-Ying Cai
, James L. Boyer
·
Annals of Translational Medicine
·
122
PDF
ATP8B1 Deficiency Disrupts the Bile Canalicular Membrane Bilayer Structure in Hepatocytes, But FXR Expression and Activity Are Maintained
2008
·
Shi–Ying Cai
, Samir Gautam
, et al.
·
Gastroenterology
·
119
PDF
Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells
2010
·
Hongwei He
, Albert Mennone
, et al.
·
Hepatology
·
118
PDF
Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis
2018
·
Xinshou Ouyang
, Sheng-Na Han
, et al.
·
Cell Metabolism
·
115
PDF
Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression
2010
·
Shuhua Xu
, Jittima Weerachayaphorn
, et al.
·
American Journal of Physiology-Gastrointestinal and Liver Physiology
·
96
Elevated hepatic multidrug resistance-associated protein 3/ATP-binding cassette subfamily C 3 expression in human obstructive cholestasis is mediated through tumor necrosis factor alpha and c-Jun NH2-terminal kinase/stress-activated protein kinase–signaling pathway
2011
·
Jin Chai
, Yu He
, et al.
·
Hepatology
·
95
PDF
The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology
2021
·
Baixue Li
, Shi-Ying Cai
, et al.
·
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
·
89
PDF
A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division
1999
·
Shi-Ying Cai
, Roger W. Babbitt
, et al.
·
Proceedings of the National Academy of Sciences
·
88
Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms
2010
·
Shi-Ying Cai
, Hongwei He
, et al.
·
Journal of Lipid Research
·
85
PDF
Elevated hepatic expression of H19 long noncoding RNA contributes to diabetic hyperglycemia
2018
·
Na Zhang
, Tingting Geng
, et al.
·
JCI Insight
·
80
PDF
Nuclear factor erythroid 2–related factor 2 is a positive regulator of human bile salt export pump expression # †
2009
·
Jittima Weerachayaphorn
, Shi-Ying Cai
, et al.
·
Hepatology
·
75
PDF
A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis
2020
·
Yetao Xu
, Xiaoli Sun
, et al.
·
Cell Reports
·
72
PDF
The anti-fibrotic effects of epigallocatechin-3-gallate in bile duct-ligated cholestatic rats and human hepatic stellate LX-2 cells are mediated by the PI3K/Akt/Smad pathway
2015
·
Dong-ke Yu
, Cai-xia Zhang
, et al.
·
Acta Pharmacologica Sinica
·
71
PDF
Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis
2015
·
Jin Chai
, Shi-Ying Cai
, et al.
·
Journal of Hepatology
·
70
Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations
2001
·
Shi-Ying Cai
, Lin Wang
, et al.
·
American Journal of Physiology-Gastrointestinal and Liver Physiology
·
65
Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis
2020
·
Shi-Ying Cai
, Dongke Yu
, et al.
·
Journal of Hepatology
·
62
PDF
FXR: a target for cholestatic syndromes?
2006
·
Shi-Ying Cai
, James L Boyer
·
Expert Opinion on Therapeutic Targets
·
62
Unique DUOX2+ACE2+ small cholangiocytes are pathogenic targets for primary biliary cholangitis
2023
·
Xi Li
, Yan Li
, et al.
·
Nature Communications
·
57
PDF
Runt-related transcription factor-1 ameliorates bile acid–induced hepatic inflammation in cholestasis through JAK/STAT3 signaling
2023
·
Liangjun Zhang
, Qiong Pan
, et al.
·
Hepatology
·
56
Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct–Ligated Mouse
2019
·
Shi-Ying Cai
, Maoxu Ge
, et al.
·
Cellular and Molecular Gastroenterology and Hepatology
·
51
PDF
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Works count:
74
Citation count:
3,738
H-index:
36
I10-index:
55
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