Author

Keisuke Kitakaze

Observed names: K. Kitakaze, KEISUKE KITAKAZE, KITAKAZE, Keisuke, Kitakaze Keisuke, 北風, 圭介

Observed institutions: Kawasaki Medical School, Tokushima University

ORCID: 0000-0002-4852-1257

Observed ORCID: 0000-0002-4852-1257

OpenAlex ID: A5011013891

Chemical Synthesis of Biologically Active Monoglycosylated GM2‐Activator Protein Analogue Using N‐Sulfanylethylanilide Peptide

2013 · Kohei Sato, Akira Shigenaga, et al. · Angewandte Chemie International Edition · 170

Growth differentiation factor 15 facilitates lung fibrosis by activating macrophages and fibroblasts

2020 · Yasuhiro Takenouchi, Keisuke Kitakaze, et al. · Experimental Cell Research · 79

Therapeutic Potential of Intracerebroventricular Replacement of Modified Human β-Hexosaminidase B for GM2 Gangliosidosis

2011 · Kazuhiko Matsuoka, Tomomi Tamura, et al. · Molecular Therapy · 66

PDF

Lyso-GM2 Ganglioside: A Possible Biomarker of Tay-Sachs Disease and Sandhoff Disease

2011 · Takashi Kodama, Tadayasu Togawa, et al. · PLoS ONE · 47

PDF

ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model

2021 · Keisuke Kitakaze, Miho Oyadomari, et al. · Molecular Metabolism · 39

PDF

Protease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model

2016 · Keisuke Kitakaze, Yasumichi Mizutani, et al. · Journal of Clinical Investigation · 34

PDF

Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity

2019 · Keisuke Kitakaze, Shusuke Taniuchi, et al. · eLife · 28

The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate

2015 · Kohei Sato, Keisuke Kitakaze, et al. · Chemical Communications · 23

PDF

Development of a Chemical Methodology for the Preparation of Peptide Thioesters Applicable to Naturally Occurring Peptides Using a Sequential Quadruple Acyl Transfer System

2015 · Yusuke Tsuda, Akira Shigenaga, et al. · ChemistryOpen · 20

PDF

Sphingosine 1-phosphate receptor type 2 positively regulates interleukin (IL)-4/IL-13-induced STAT6 phosphorylation

2021 · Yasuo Okamoto, Keisuke Kitakaze, et al. · Cellular Signalling · 15

Involvement of acid ceramidase in the degradation of bioactive N-acylethanolamines

2021 · Kazuhito Tsuboi, Tatsuya Tai, et al. · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 15

Chemical Synthesis of Biologically Active Monoglycosylated GM2‐Activator Protein Analogue Using N‐Sulfanylethylanilide Peptide

2013 · Kohei Sato, Akira Shigenaga, et al. · Angewandte Chemie · 12

Coculture in vitro with endothelial cells induces cytarabine resistance of acute myeloid leukemia cells in a VEGF-A/VEGFR-2 signaling–independent manner

2021 · Shuichiro Okamoto, Kei Miyano, et al. · Biochemical and Biophysical Research Communications · 10

GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator

2023 · Keisuke Kitakaze, Hanif Ali, et al. · Communications Biology · 9

PDF

Development of a selective fluorescence-based enzyme assay for glycerophosphodiesterase family members GDE4 and GDE7

2021 · Keisuke Kitakaze, Kazuhito Tsuboi, et al. · Journal of Lipid Research · 7

PDF

Tailored Synthesis of 162‐Residue S‐Monoglycosylated GM2‐Activator Protein (GM2AP) Analogues that Allows Facile Access to a Protein Library

2016 · Takahiro Nakamura, Kohei Sato, et al. · ChemBioChem · 7

N-glycan-modified α-L-iduronidase produced by transgenic silkworms ameliorates clinical signs in a Japanese macaque with mucopolysaccharidosis I

2025 · Chika Shinoda, Keisuke Kitakaze, et al. · Communications Medicine · 4

PDF

GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression

2024 · Yasuo Okamoto, Keisuke Kitakaze, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 4

Targeted Deletion of ATF4 in ß Cells Leads to the Vulnerability and Dedifferentiation during ER Stress

2018 · KEISUKE KITAKAZE, KIYOE KURAHASHI, et al. · Diabetes · 4

Sweat Protects against Contact Hypersensitivity: Transient Sweat Suppression Compromises Skin Barrier Function in Mice

2024 · Hironobu Ishimaru, Kenta Nakamoto, et al. · Journal of Investigative Dermatology · 3

Author response: Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity

2019 · Keisuke Kitakaze, Shusuke Taniuchi, et al. · 3

Combined replacement effects of human modified β-hexosaminidase B and GM2 activator protein on GM2 gangliosidoses fibroblasts

2016 · Keisuke Kitakaze, Chikako Tasaki, et al. · Biochemistry and Biophysics Reports · 2

PDF

PERK/ATF3-dependent induction of GDE4 modulates intracellular lysophospholipid-PPARα/γ signaling

2026 · Keisuke Kitakaze, Risa Misumi, et al. · bioRxiv (Cold Spring Harbor Laboratory)

PDF

Alveolar epithelial cell senescence predominates over macrophage senescence in driving pulmonary fibrosis

2026 · Yasuhiro Takenouchi, Keisuke Kitakaze, et al. · Research Square

PDF

AAV-based gene therapy with modified HEXB confers lasting therapeutic benefits in GM2 gangliosidosis models