Author

Patrick Lacombe

Observed names: Lacombe Patrick, P. LACOMBE, P. Lacombe

Observed institution: Merck Canada Inc. (Canada)

OpenAlex ID: A5011192338

Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment

2010 · Michel Gallant, Renee Aspiotis, et al. · Bioorganic & Medicinal Chemistry Letters · 44

Structure–Activity Relationship of Biaryl Acylsulfonamide Analogues on the Human EP3 Prostanoid Receptor

2002 · M. Gallant, M.C. Carrière, et al. · Bioorganic & Medicinal Chemistry Letters · 44

Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor

2005 · Dwight Macdonald, Anthony Mastracchio, et al. · Bioorganic & Medicinal Chemistry Letters · 31

L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition

2007 · Z. Huang, R. Dias, et al. · Biochemical Pharmacology · 30

Reduction of olefins on solid support using diimide

1998 · Patrick Lacombe, Bastien Castagner, et al. · Tetrahedron Letters · 30

A ring closing metathesis-osmylation approach to oxygenated oxepanes as carbohydrate surrogates

1999 · Jerome C.Y. Wong, Patrick Lacombe, et al. · Tetrahedron Letters · 24

New class of biphenylene dibenzazocinones as potent ligands for the human EP1 prostanoid receptor

1999 · Réjean Ruel, Patrick Lacombe, et al. · Bioorganic & Medicinal Chemistry Letters · 22

Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of pyridone-substituted piperidines

2011 · Austin Chen, Louis-Charles Campeau, et al. · Bioorganic & Medicinal Chemistry Letters · 17

Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension

2010 · Austin Chen, Christopher Bayly, et al. · Bioorganic & Medicinal Chemistry Letters · 17

Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study

2010 · Austin Chen, Daniel Dubé, et al. · Bioorganic & Medicinal Chemistry Letters · 16

Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of tertiary alcohol-bearing piperidines

2011 · Austin Chen, Elizabeth Cauchon, et al. · Bioorganic & Medicinal Chemistry Letters · 15

Samarium(II) Iodide-Mediated Synthesis of Chlorohydrins

1998 · Bastien Castagner, Patrick Lacombe, et al. · The Journal of Organic Chemistry · 14

Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents

2011 · Jean-François Lévesque, Kelly Bleasby, et al. · Bioorganic & Medicinal Chemistry Letters · 13

Design, synthesis, and biological evaluation of 8-biarylquinolines: A novel class of PDE4 inhibitors

2008 · Michel Gallant, Nathalie Chauret, et al. · Bioorganic & Medicinal Chemistry Letters · 12

Design and synthesis of potent, isoxazole-containing renin inhibitors

2012 · Pierre-André Fournier, Mélissa Arbour, et al. · Bioorganic & Medicinal Chemistry Letters · 10

The discovery and synthesis of potent zwitterionic inhibitors of renin

2011 · Renee Aspiotis, Austin Chen, et al. · Bioorganic & Medicinal Chemistry Letters · 10

3,4-Diarylpiperidines as potent renin inhibitors

2012 · Patrick Lacombe, Mélissa Arbour, et al. · Bioorganic & Medicinal Chemistry Letters · 9

Identification of a new biaryl scaffold generating potent renin inhibitors

2010 · Patrick Lacombe, Renée Aspiotis, et al. · Bioorganic & Medicinal Chemistry Letters · 9

Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors

2009 · Patrick Lacombe, Nathalie Chauret, et al. · Bioorganic & Medicinal Chemistry Letters · 3

Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors

2006 · Patrick Lacombe, Denis Deschênes, et al. · Bioorganic & Medicinal Chemistry Letters · 3

Substituted 8-arylquinoline

2002 · Mastracchio Anthony, Lacombe Patrick, et al. · Europe PMC (PubMed Central)

ChemInform Abstract: A Ring Closing Metathesis—Osmylation Approach to Oxygenated Oxepanes as Carbohydrate Surrogates.

2000 · Jerome C. Y. Wong, Patrick Lacombe, et al. · ChemInform

ChemInform Abstract: Samarium(II) Iodide‐Mediated Synthesis of Chlorohydrins.

1998 · B. CASTAGNER, P. LACOMBE, et al. · ChemInform

Works count: 23

Citation count: 373

H-index: 13

I10-index: 16