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Caroline M. Gorvin

Observed names: C. Gorvin, C.M. Gorvin, Caroline M. Gorvin, Caroline Gorvin, Caroline M Gorvin, Caroline M. Gorvin, Gorvin, Caroline, Gorvin, Caroline M.
Observed institutions: University of Nottingham, University of Southern Denmark, Glasgow Royal Infirmary, Churchill Hospital, Odense University Hospital, University of Oxford, Landeskrankenhaus Feldkirch, NIHR Oxford Biomedical Research Centre, Medawar Building for Pathogen Research, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Birmingham
ORCID: 0000-0002-1361-9174
Observed ORCID: 0000-0002-1361-9174
OpenAlex ID: A5011297390
Whole-Exome Sequencing Studies of Nonhereditary (Sporadic) Parathyroid Adenomas
2012 · Paul J. Newey, M. Andrew Nesbit, et al. · The Journal of Clinical Endocrinology & Metabolism · 149
Mutant Prolactin Receptor and Familial Hyperprolactinemia
2013 · Paul J. Newey, Caroline M. Gorvin, et al. · New England Journal of Medicine · 136
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Whole-Exome Sequencing Studies of Nonfunctioning Pituitary Adenomas
2013 · Paul J. Newey, M. Andrew Nesbit, et al. · The Journal of Clinical Endocrinology & Metabolism · 93
Adaptor protein-2 sigma subunit mutations causing familial hypocalciuric hypercalcaemia type 3 (FHH3) demonstrate genotype–phenotype correlations, codon bias and dominant-negative effects
2015 · Fadil M. Hannan, Sarah A. Howles, et al. · Human Molecular Genetics · 92
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Receptor-mediated endocytosis and endosomal acidification is impaired in proximal tubule epithelial cells of Dent disease patients
2013 · Caroline M. Gorvin, Martijn J. Wilmer, et al. · Proceedings of the National Academy of Sciences · 90
Familial Hypocalciuric Hypercalcemia Type 1 and Autosomal-Dominant Hypocalcemia Type 1: Prevalence in a Large Healthcare Population
2020 · Ridge Dershem, Caroline M. Gorvin, et al. · The American Journal of Human Genetics · 86
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AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity
2018 · Caroline M. Gorvin, Angela Rogers, et al. · Cell Reports · 85
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The prolactin receptor: Diverse and emerging roles in pathophysiology
2015 · Caroline M. Gorvin · Journal of Clinical & Translational Endocrinology · 72
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Gα11 mutation in mice causes hypocalcemia rectifiable by calcilytic therapy
2017 · Caroline M. Gorvin, Fadil M. Hannan, et al. · JCI Insight · 69
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Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
2024 · Morten S. Hansen, Kaja Madsen, et al. · Bone Research · 68
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GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells
2023 · Morten S. Hansen, Kent Søe, et al. · European Journal of Endocrinology · 64
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Molecular and clinical insights from studies of calcium-sensing receptor mutations
2019 · Caroline M Gorvin · Journal of Molecular Endocrinology · 64
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Cinacalcet for Symptomatic Hypercalcemia Caused by AP2S1 Mutations
2016 · Sarah A. Howles, Fadil M. Hannan, et al. · New England Journal of Medicine · 58
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Cinacalcet Rectifies Hypercalcemia in a Patient With Familial Hypocalciuric Hypercalcemia Type 2 (FHH2) Caused by a Germline Loss-of-Function Gα11 Mutation
2017 · Caroline M Gorvin, Fadil M Hannan, et al. · Journal of Bone and Mineral Research · 54
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A G-protein Subunit-α11 Loss-of-Function Mutation, Thr54Met, Causes Familial Hypocalciuric Hypercalcemia Type 2 (FHH2)
2016 · Caroline M Gorvin, Treena Cranston, et al. · Journal of Bone and Mineral Research · 51
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A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin–biased signaling
2018 · Caroline M. Gorvin, Valerie N. Babinsky, et al. · Science Signaling · 49
Autosomal Dominant Hypercalciuria in a Mouse Model Due to a Mutation of the Epithelial Calcium Channel, TRPV5
2013 · Nellie Y. Loh, Liz Bentley, et al. · PLoS ONE · 44
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Identification of a G-Protein Subunit-α11 Gain-of-Function Mutation, Val340Met, in a Family With Autosomal Dominant Hypocalcemia Type 2 (ADH2)
2016 · Sian E Piret, Caroline M Gorvin, et al. · Journal of Bone and Mineral Research · 43
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Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β cells
2023 · Weiwei Xu, M.M. Fahd Qadir, et al. · Cell Reports · 42
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Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy
2017 · Valerie N Babinsky, Fadil M Hannan, et al. · Endocrinology · 41
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Association of prolactin receptor (PRLR) variants with prolactinomas
2018 · Caroline M Gorvin, Paul J Newey, et al. · Human Molecular Genetics · 40
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Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors
2017 · Kelly L. Roszko, Ruiye Bi, et al. · JCI Insight · 39
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Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders
2016 · Valerie N. Babinsky, Fadil M. Hannan, et al. · Journal of Biological Chemistry · 37
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G protein-coupled receptor (GPCR) gene variants and human genetic disease
2024 · Miles D. Thompson, Maire E. Percy, et al. · Critical Reviews in Clinical Laboratory Sciences · 35
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Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias
2018 · Caroline M Gorvin, Morten Frost, et al. · Human Molecular Genetics · 32
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Works count: 167
Citation count: 2,251
H-index: 28
I10-index: 53
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