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Xenia Jimenez

A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo.
2003 · Douglas Burtrum, Zhenping Zhu, et al. · PubMed · 348
Tailoring in Vitro Selection for a Picomolar Affinity Human Antibody Directed against Vascular Endothelial Growth Factor Receptor 2 for Enhanced Neutralizing Activity
2003 · Dan Lu, Juqun Shen, et al. · Journal of Biological Chemistry · 183
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Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity
2003 · Z Zhu, K Hattori, et al. · Leukemia · 158
Anti-Vascular Endothelial Growth Factor Receptor-1 Antagonist Antibody as a Therapeutic Agent for Cancer
2006 · Yan Wu, Zhaojing Zhong, et al. · Clinical Cancer Research · 152
Monoclonal antibody cetuximab binds to and down-regulates constitutively activated epidermal growth factor receptor vIII on the cell surface.
2007 · Dipa Patel, Armin Lahiji, et al. · PubMed · 148
Selection of high affinity human neutralizing antibodies to VEGFR2 from a large antibody phage display library for antiangiogenesis therapy
2001 · Dan Lu, Xenia Jimenez, et al. · International Journal of Cancer · 138
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Simultaneous Blockade of Both the Epidermal Growth Factor Receptor and the Insulin-like Growth Factor Receptor Signaling Pathways in Cancer Cells with a Fully Human Recombinant Bispecific Antibody
2004 · Dan Lu, Haifan Zhang, et al. · Journal of Biological Chemistry · 127
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Anti–Transforming Growth Factor β Receptor II Antibody Has Therapeutic Efficacy against Primary Tumor Growth and Metastasis through Multieffects on Cancer, Stroma, and Immune Cells
2010 · Zhaojing Zhong, Kyla Driscoll Carroll, et al. · Clinical Cancer Research · 126
Targeting the platelet-derived growth factor receptor α with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts: Implications as a potential therapeutic target
2005 · Nick Loizos, Yan Xu, et al. · Molecular Cancer Therapeutics · 120
Potent neutralization of VEGF biological activities with a fully human antibody Fab fragment directed against VEGF receptor 2
2006 · Hua-Quan Miao, Kun Hu, et al. · Biochemical and Biophysical Research Communications · 89
Involvement of the VEGF receptor 3 in tubular morphogenesis demonstrated with a human anti-human VEGFR-3 monoclonal antibody that antagonizes receptor activation by VEGF-C
2004 · Kris Persaud, Jean-Christophe Tille, et al. · Journal of Cell Science · 79
A recombinant, fully human, bispecific antibody neutralizes the biological activities mediated by both vascular endothelial growth factor receptors 2 and 3
2005 · Xenia Jimenez, Dan Lu, et al. · Molecular Cancer Therapeutics · 66
Development of a Fully Human Anti-PDGFRβ Antibody That Suppresses Growth of Human Tumor Xenografts and Enhances Antitumor Activity of an Anti-VEGFR2 Antibody
2009 · Juqun Shen, Marie Danielle Vil, et al. · Neoplasia · 64
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The effect of variable domain orientation and arrangement on the antigen-binding activity of a recombinant human bispecific diabody
2004 · Dan Lu, Xenia Jimenez, et al. · Biochemical and Biophysical Research Communications · 63
Inhibition of vascular endothelial growth factor induced mitogenesis of human endothelial cells by a chimeric anti-kinase insert domain-containing receptor antibody
1999 · Zhenping Zhu, Dan Lu, et al. · Cancer Letters · 50
Single Variable Domain-IgG Fusion
2006 · Juqun Shen, Marie Danielle Vil, et al. · Journal of Biological Chemistry · 49
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Complete inhibition of vascular endothelial growth factor (VEGF) activities with a bifunctional diabody directed against both VEGF kinase receptors, fms-like tyrosine kinase receptor and kinase insert domain-containing receptor.
2001 · D Lu, X Jimenez, et al. · PubMed · 49
Di-diabody: a novel tetravalent bispecific antibody molecule by design
2003 · Dan Lu, Xenia Jimenez, et al. · Journal of Immunological Methods · 43
An antibody directed against PDGF receptor β enhances the antitumor and the anti-angiogenic activities of an anti-VEGF receptor 2 antibody
2007 · Juqun Shen, Marie D. Vil, et al. · Biochemical and Biophysical Research Communications · 39
Fab-scFv fusion protein: an efficient approach to production of bispecific antibody fragments
2002 · Dan Lu, Xenia Jimenez, et al. · Journal of Immunological Methods · 39
An efficient route to the production of an IgG-like bispecific antibody
2000 · Zhuang Zuo, Xenia Jimenez, et al. · Protein Engineering Design and Selection · 39
Acquired antagonistic activity of a bispecific diabody directed against two different epitopes on vascular endothelial growth factor receptor 2
1999 · Dan Lu, Helen Kotanides, et al. · Journal of Immunological Methods · 38
Inhibition of Both the Autocrine and the Paracrine Growth of Human Leukemia with a Fully Human Antibody Directed Against Vascular Endothelial Growth Factor Receptor 2
2004 · Haifan Zhang, Yiwen Li, et al. · Leukemia & lymphoma/Leukemia and lymphoma · 36
Single variable domain antibody as a versatile building block for the construction of IgG-like bispecific antibodies
2006 · Juqun Shen, Marie Danielle Vil, et al. · Journal of Immunological Methods · 35
Cell-based selection of internalizing fully human antagonistic antibodies directed against FLT3 for suppression of leukemia cell growth
2005 · B Williams, A Atkins, et al. · Leukemia · 35
Works count: 38
Citation count: 2,372
H-index: 25
I10-index: 28
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