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Paula Costales

Microbial mucosal colonic shifts associated with the development of colorectal cancer reveal the presence of different bacterial and archaeal biomarkers
2014 · L. Mira-Pascual, R. Cabrera-Rubio, et al. · Journal of Gastroenterology · 271
Hypoxia Stimulates Low-Density Lipoprotein Receptor–Related Protein-1 Expression Through Hypoxia-Inducible Factor-1α in Human Vascular Smooth Muscle Cells
2011 · Jose Castellano, Rosa Aledo, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 84
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K Domain CR9 of Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1) Is Critical for Aggregated LDL-induced Foam Cell Formation from Human Vascular Smooth Muscle Cells
2015 · Paula Costales, Pablo Fuentes-Prior, et al. · Journal of Biological Chemistry · 72
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Sterol Regulatory Element-binding Protein-2 Negatively Regulates Low Density Lipoprotein Receptor-related Protein Transcription
2006 · V. Llorente-Cortés, P. Costales, et al. · Journal of Molecular Biology · 69
Cholesteryl Esters of Aggregated LDL Are Internalized by Selective Uptake in Human Vascular Smooth Muscle Cells
2005 · Vicenta Llorente-Cortés, Marta Otero-Viñas, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 61
Angiotensin II upregulates LDL receptor-related protein (LRP1) expression in the vascular wall: a new pro-atherogenic mechanism of hypertension
2008 · J. Sendra, V. Llorente-Cortes, et al. · Cardiovascular Research · 55
EC-70124, a Novel Glycosylated Indolocarbazole Multikinase Inhibitor, Reverts Tumorigenic and Stem Cell Properties in Prostate Cancer by Inhibiting STAT3 and NF-κB
2016 · Gianluca Civenni, Nicole Longoni, et al. · Molecular Cancer Therapeutics · 44
Lipopolysaccharide downregulates CD91/low-density lipoprotein receptor-related protein 1 expression through SREBP-1 overexpression in human macrophages
2012 · P. Costales, J. Castellano, et al. · Atherosclerosis · 44
Selective role of sterol regulatory element binding protein isoforms in aggregated LDL-induced vascular low density lipoprotein receptor-related protein-1 expression
2010 · P. Costales, R. Aledo, et al. · Atherosclerosis · 36
Inhibition of FLT3 and PIM Kinases by EC-70124 Exerts Potent Activity in Preclinical Models of Acute Myeloid Leukemia
2018 · Noelia Puente-Moncada, Paula Costales, et al. · Molecular Cancer Therapeutics · 24
Genetic Engineering in Combination with Semi‐Synthesis Leads to a New Route for Gram‐Scale Production of the Immunosuppressive Natural Product Brasilicardin A
2021 · Alma Botas, Michael Eitel, et al. · Angewandte Chemie International Edition · 19
IMiDs mobilize acute myeloid leukemia blasts to peripheral blood through downregulation of CXCR4 but fail to potentiate AraC/Idarubicin activity in preclinical models of non del5q/5q- AML
2018 · Belen Lopez-Millan, Rafael Diaz de la Guardia, et al. · OncoImmunology · 16
The multikinase inhibitor EC‐70124 synergistically increased the antitumor activity of doxorubicin in sarcomas
2018 · Oscar Estupiñan, Laura Santos, et al. · International Journal of Cancer · 15
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Transcriptional Reprogramming and Inhibition of Tumor-propagating Stem-like Cells by EC-8042 in ERG-positive Prostate Cancer
2018 · Dheeraj Shinde, Domenico Albino, et al. · European Urology Oncology · 12
Molecular and functional characterization of LRP1 promoter polymorphism c.1-25 C>G (rs138854007)
2014 · R. Aledo, P. Costales, et al. · Atherosclerosis · 8
Fragment-Based Discovery and Structure-Led Optimization of MSC778, the First Potent, Selective, and Orally Bioavailable FEN1 Inhibitor
2025 · Sam E. Mann, Julien Lefranc, et al. · Journal of Medicinal Chemistry · 7
Novel chiral naphthalimide-cycloalkanediamine conjugates: Design, synthesis and antitumor activity
2021 · Paula Costales, Nicolás Ríos-Lombardía, et al. · Bioorganic Chemistry · 6
The Multi-Kinase Inhibitor EC-70124 Is a Promising Candidate for the Treatment of FLT3-ITD-Positive Acute Myeloid Leukemia
2022 · Belen Lopez-Millan, Paula Costales, et al. · Cancers · 5
The multi-kinase inhibitor EC-70124 delivers a double-hit to prostate cancer stem cells interfering with both STAT3 and NF-kB signaling
2017 · G. Civenni, D. Shinde, et al. · European Urology Supplements · 5
Abstract 312: The ATR inhibitor ART0380 shows preclinical efficacy in monotherapy or in combination with gemcitabine, aPD1, PARP inhibitors and topoisomerase 1 poisons
2023 · Jayesh Bhanabhai Majithiya, Marina Roy Luzarraga, et al. · Cancer Research · 4
The Pharmacologic Profile of ART6043, a First-in-Class Clinical DNA Polymerase Theta Polymerase Domain Inhibitor Potentiating PARP Inhibitor Efficacy
2026 · Helen M.R. Robinson, Vera Grinkevich, et al. · Clinical Cancer Research · 2
139 (PB127): ART6043: a first-in-class clinical DNA Polymerase Theta polymerase domain inhibitor for potentiating PARP inhibitor efficacy
2024 · H. Robinson, V. Grinkevich, et al. · European Journal of Cancer · 1
Genetic Engineering in Combination with Semi‐Synthesis Leads to a New Route for Gram‐Scale Production of the Immunosuppressive Natural Product Brasilicardin A
2021 · Alma Botas, Michael Eitel, et al. · Angewandte Chemie · 1
487 EC-70124, a multi-kinase inhibitor, blocks NF-kB and STAT3 dependent signaling in prostate cancer stem cells
2014 · G. Civenni, P. Costales, et al. · European Journal of Cancer · 1
La hipoxia estimula la expresión del receptor LRP1 a través del factor de transcripción HIF-1α en células musculares lisas de pared vascular humana
2012 · José Castellano, Rosa Aledo, et al. · Clínica e Investigación en Arteriosclerosis · 1
Works count: 62
Citation count: 863
H-index: 13
I10-index: 14
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