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Nicole M. Okeley

Observed names: N M Okeley, N. Okeley, NM Okeley, Nicole M Okeley, Nicole Okeley
ORCID: 0000-0003-4185-1488
Observed ORCID: 0000-0003-4185-1488
OpenAlex ID: A5011719233
Antibody–drug conjugates: targeted drug delivery for cancer
2010 · Stephen C Alley, Nicole M Okeley, et al. · Current Opinion in Chemical Biology · 660
Contribution of Linker Stability to the Activities of Anticancer Immunoconjugates
2008 · Stephen C. Alley, Dennis R. Benjamin, et al. · Bioconjugate Chemistry · 486
Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate
2010 · Nicole M. Okeley, Jamie B. Miyamoto, et al. · Clinical Cancer Research · 394
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Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models
2016 · Fu Li, Kim K. Emmerton, et al. · Cancer Research · 356
A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology
2013 · Scott C. Jeffrey, Patrick J. Burke, et al. · Bioconjugate Chemistry · 247
Development and Properties of β-Glucuronide Linkers for Monoclonal Antibody−Drug Conjugates
2006 · Scott C. Jeffrey, Jamie B. Andreyka, et al. · Bioconjugate Chemistry · 193
Development of orally active inhibitors of protein and cellular fucosylation
2013 · Nicole M. Okeley, Stephen C. Alley, et al. · Proceedings of the National Academy of Sciences · 189
Facile Chemoselective Synthesis of Dehydroalanine-Containing Peptides
2000 · Nicole M. Okeley, Yantao Zhu, et al. · Organic Letters · 165
Optimization of a PEGylated Glucuronide-Monomethylauristatin E Linker for Antibody–Drug Conjugates
2016 · Patrick J. Burke, Joseph Z. Hamilton, et al. · Molecular Cancer Therapeutics · 159
The Pharmacologic Basis for Antibody-Auristatin Conjugate Activity
2009 · Stephen C. Alley, Xinqun Zhang, et al. · Journal of Pharmacology and Experimental Therapeutics · 135
Metabolic Engineering of Monoclonal Antibody Carbohydrates for Antibody–Drug Conjugation
2013 · Nicole M. Okeley, Brian E. Toki, et al. · Bioconjugate Chemistry · 120
Novel cofactors via post-translational modifications of enzyme active sites
2000 · Nicole M Okeley, Wilfred A van der Donk · Chemistry & Biology · 105
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Anti-CD30 diabody-drug conjugates with potent antitumor activity
2008 · Kristine M. Kim, Charlotte F. McDonagh, et al. · Molecular Cancer Therapeutics · 93
Potent antitumor activity of the anti-CD19 auristatin antibody drug conjugate hBU12-vcMMAE against rituximab-sensitive and -resistant lymphomas
2009 · Hans-Peter Gerber, May Kung-Sutherland, et al. · Blood · 85
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SpaC and NisC, the Cyclases Involved in Subtilin and Nisin Biosynthesis, Are Zinc Proteins
2003 · Nicole M. Okeley, Moushumi Paul, et al. · Biochemistry · 73
Intracellular Actions of Group IIA Secreted Phospholipase A2 and Group IVA Cytosolic Phospholipase A2 Contribute to Arachidonic Acid Release and Prostaglandin Production in Rat Gastric Mucosal Cells and Transfected Human Embryonic Kidney Cells
2006 · Zhanglin Ni, Nicole M. Okeley, et al. · Journal of Biological Chemistry · 69
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Engineered cysteine antibodies: an improved antibody-drug conjugate platform with a novel mechanism of drug-linker stability
2018 · D Sussman, L Westendorf, et al. · Protein Engineering Design and Selection · 56
Synthesis of Isotopically Labeled Arachidonic Acids To Probe the Reaction Mechanism of Prostaglandin H Synthase
2002 · Sheng Peng, Nicole M. Okeley, et al. · Journal of the American Chemical Society · 52
A Designed Probe for Acidic Phospholipids Reveals the Unique Enriched Anionic Character of the Cytosolic Face of the Mammalian Plasma Membrane
2004 · Nicole M. Okeley, Michael H. Gelb · Journal of Biological Chemistry · 45
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An in Vitro Assay Using Cultured Kupffer Cells Can Predict the Impact of Drug Conjugation on in Vivo Antibody Pharmacokinetics
2020 · David W Meyer, Lauren B Bou, et al. · Molecular Pharmaceutics · 35
The Fucosylation Inhibitor, 2-Fluorofucose, Inhibits Vaso-Occlusion, Leukocyte-Endothelium Interactions and NF-ĸB Activation in Transgenic Sickle Mice
2015 · John D. Belcher, Chunsheng Chen, et al. · PLoS ONE · 30
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Development of Novel Antibody–Camptothecin Conjugates
2020 · Ryan D. Lyski, Lauren B. Bou, et al. · Molecular Cancer Therapeutics · 29
SGN-CD228A Is an Investigational CD228-Directed Antibody–Drug Conjugate with Potent Antitumor Activity across a Wide Spectrum of Preclinical Solid Tumor Models
2023 · Rebecca Mazahreh, Marsha L. Mason, et al. · Molecular Cancer Therapeutics · 28
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Heterologous expression and purification of SpaB involved in subtilin biosynthesis
2002 · Lili Xie, Champak Chatterjee, et al. · Biochemical and Biophysical Research Communications · 26
Structural Characterization of a Pentadienyl Radical Intermediate Formed during Catalysis by Prostaglandin H Synthase-2
2001 · Sheng Peng, Nicole M. Okeley, et al. · Journal of the American Chemical Society · 26
Works count: 110
Citation count: 4,027
H-index: 25
I10-index: 31
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