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Angela C. Boroughs
Observed names:
Angela Boroughs,
Angela C Boroughs
Institution:
Arsenal Biosciences (United States)
Observed institutions:
Harvard University,
Massachusetts General Hospital,
Arsenal Biosciences (United States),
Center for Computational and Integrative Biology, Massachusetts General Hospital
ORCID:
0000-0002-9701-9538
Observed ORCID:
0000-0002-9701-9538
OpenAlex ID:
A5012990902
CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity
2019
·
Bryan D. Choi
, Xiaoling Yu
, et al.
·
Nature Biotechnology
·
586
Chimeric antigen receptor costimulation domains modulate human regulatory T cell function
2019
·
Angela C. Boroughs
, Rebecca C. Larson
, et al.
·
JCI Insight
·
147
PDF
C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions
2018
·
Vishnu Mohanan
, Toru Nakata
, et al.
·
Science
·
126
Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma
2019
·
Andrea Schmidts
, Maria Ormhøj
, et al.
·
Blood Advances
·
119
A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq
2020
·
Angela C. Boroughs
, Rebecca C. Larson
, et al.
·
Molecular Therapy
·
106
PDF
TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation
2016
·
Daniel B. Graham
, Ariel Lefkovith
, et al.
·
Cell Reports
·
66
PDF
Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources
2020
·
Andrea Schmidts
, Leah C Marsh
, et al.
·
Journal for ImmunoTherapy of Cancer
·
29
PDF
Quantifying requirements for mitochondrial apoptosis in CAR T killing of cancer cells
2023
·
Alexandra L. Pourzia
, Michael L. Olson
, et al.
·
Cell Death and Disease
·
21
PDF
334 Computational mapping of CAR-T cell exhaustion through single-cell perturbation screens
2024
·
Li Wang
, David DeTomaso
, et al.
·
Journal for ImmunoTherapy of Cancer
·
2
Abstract B037: AB-2100, a PSMA-inducible CA9-specific CAR T cell product intended for the treatment of ccRCC provides long-term tumor responses in preclinical mouse model
2024
·
Suchismita Mohanty
, Jeremy Chen
, et al.
·
Cancer Immunology Research
·
1
Development of AB-2100, an autologous integrated circuit T (ICT) cell therapy targeting CA9 intended for the treatment of ccRCC.
2024
·
Mark Landon
, Irene Scarfo
, et al.
·
Journal of Clinical Oncology
·
1
Abstract 2854: Logic gates controlled by priming receptors increase specificity and potency of CAR T cells
2022
·
Jasper Williams
, Kevin Martinez
, et al.
·
Cancer Research
·
1
DINOcell: learning generalizable perturbation effects through self-distillation
2025
·
Jonathan Li
, Nilgun Tasdemir
, et al.
·
bioRxiv (Cold Spring Harbor Laboratory)
PDF
1125 gx1: virtual target identification for overcoming T cell exhaustion
2025
·
Amaro Taylor-Weiner
, Sofia Kyriazopoulou Panagiotopoulou
, et al.
·
Journal for ImmunoTherapy of Cancer
PDF
282 Improving solid tumor CAR-T therapies by modulating T cell transcriptional states using combinatorial in vitro CRISPR screening followed by in vivo validation
2024
·
Lina M Leon
, Angela C Boroughs
, et al.
·
Journal for ImmunoTherapy of Cancer
Abstract 7034: Pooled CRISPR screening coupled with single-cell sequencing identifies modifiers of CAR T cell state in the context of chronic antigen stimulation
2024
·
Sahil Joshi
, Glenn Wozniak
, et al.
·
Cancer Research
Abstract 7042: Enhancing TCR T cell function in solid tumors through in vivo combinatorial screens and single-cell analysis
2024
·
Dina Polyak
, Jessica Fuhriman
, et al.
·
Cancer Research
Abstract 38: AB-2100, a PSMA-inducible CA9-specific CAR T cell product for the treatment of ccRCC provides long-term tumor responses in preclinical mouse model
2024
·
Suchismita Mohanty
, Jeremy Chen
, et al.
·
Cancer Research
301 Preclinical development of AB-2100, a PSMA neovasculature-inducible CA9 CAR resistant to FASL and TGFb mediated suppression for the treatment of ccRCC
2023
·
Irene Scarfo
, Laura Lim
, et al.
·
Journal for ImmunoTherapy of Cancer
PDF
259 Discovery of synthetic signaling pathway receptors that increase the potency of CAR-T cells through optimized STAT activity
2023
·
Thomas J Gardner
, Beatriz Millare
, et al.
·
Journal for ImmunoTherapy of Cancer
PDF
Abstract 1783: High-throughput arrayed screening of logic-gated CARs enables the selection of candidates for ccRCC with optimal potency and fidelity traits
2023
·
Nishant Mehta
, Jamie Thomas
, et al.
·
Cancer Research
Abstract 5329: High throughput screening strategies in the development of logic gated cell therapies
2023
·
Li Wang
, Sofia Kyriazopoulou Panagiotopoulou
, et al.
·
Cancer Research
Abstract 4088: A neovasculature-inducible CA9 CAR resistant to FASL and TGFb mediated suppression for the treatment of ccRCC
2023
·
Angela C. Boroughs
, Irene Scarfo
, et al.
·
Cancer Research
Abstract 1768: Multiplexed shRNA cassettes targeting orthogonal pathways (FAS/PTPN2/TGFBR) enhance the potency of integrated circuit T cells (ICTs) in multiple solid tumor models
2023
·
Thomas J. Gardner
, Adam Litterman
, et al.
·
Cancer Research
Abstract 4073: Tunable STAT activation by synthetic pathway activators (SPAs) increases engineered T-cell potency and persistence
2023
·
Thomas J. Gardner
, Beatriz Millare
, et al.
·
Cancer Research
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Works count:
29
Citation count:
1,205
H-index:
8
I10-index:
8
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