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Jeffrey J. DeStefano

Observed names: DeStefano, Jeffrey, DeStefano, Jeffrey J., J DeStefano, J J DeStefano, J. J. DeStefano, J.J. DeStefano, Jeffery J. DeStefano, Jeffrey DeStefano, Jeffrey J DeStefano, Jeffrey J Destefano, Jeffrey J. Destefano
Observed institutions: National Institutes of Health, University of Connecticut, University of Rochester Medicine, National Cancer Institute, University of Rochester, University of Maryland, College Park, Science Applications International Corporation (United States)
ORCID: 0000-0002-8710-7622
Observed ORCID: 0000-0002-8710-7622
OpenAlex ID: A5013289645
Polymerization and RNase H activities of the reverse transcriptases from avian myeloblastosis, human immunodeficiency, and Moloney murine leukemia viruses are functionally uncoupled.
1991 · J J DeStefano, R G Buiser, et al. · Journal of Biological Chemistry · 146
Requirements for strand transfer between internal regions of heteropolymer templates by human immunodeficiency virus reverse transcriptase
1992 · J J DeStefano, L M Mallaber, et al. · Journal of Virology · 130
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Selection of 2′-deoxy-2′-fluoroarabinonucleotide (FANA) aptamers that bind HIV-1 reverse transcriptase with picomolar affinity
2015 · Irani Alves Ferreira-Bravo, Christopher Cozens, et al. · Nucleic Acids Research · 124
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Determinants of the RNase H cleavage specificity of human immunodeficiency virus reverse transcriptase
1993 · Jeffrey J. Destefano, Lisa M. Mallaber, et al. · Nucleic Acids Research · 82
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The mechanism of human immunodeficiency virus reverse transcriptase-catalyzed strand transfer from internal regions of heteropolymeric RNA templates.
1994 · J.J. DeStefano, R.A. Bambara, et al. · Journal of Biological Chemistry · 74
Xeno-Nucleic Acid (XNA) 2’-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor-Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding
2021 · Irani Alves Ferreira-Bravo, Jeffrey J. DeStefano · Viruses · 66
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Human immunodeficiency virus reverse transcriptase displays a partially processive 3‘ to 5‘ endonuclease activity.
1991 · J.J. DeStefano, R.G. Buiser, et al. · Journal of Biological Chemistry · 66
Improving aptamer performance with nucleic acid mimics: de novo and post-SELEX approaches
2021 · Ricardo Oliveira, Eva Pinho, et al. · Trends in biotechnology · 60
Quantitative analysis of RNA cleavage during RNAdirected DNA synthesis by human immunodeficiency and avian myeloblastosis virus reverse transcriptases
1994 · Jeffrey J. DeStefano, Lisa M. Mallaber, et al. · Nucleic Acids Research · 60
Differing Roles of the N- and C-terminal Zinc Fingers in Human Immunodeficiency Virus Nucleocapsid Protein-enhanced Nucleic Acid Annealing
2003 · Megan J. Heath, Suchitra S. Derebail, et al. · Journal of Biological Chemistry · 59
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Parameters that influence processive synthesis and site-specific termination by human immunodeficiency virus reverse transcriptase on RNA and DNA templates
1992 · Jeffrey J. DeStefano, Rodolfo G. Buiser, et al. · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · 55
Mechanism of HIV Reverse Transcriptase Inhibition by Zinc
2011 · Katherine J. Fenstermacher, Jeffrey J. DeStefano · Journal of Biological Chemistry · 53
Parameters that influence the binding of human immunodeficiency virus reverse transcriptase to nucleic acid structures
1993 · Jeffrey J. DeStefano, Robert A. Bambara, et al. · Biochemistry · 49
Selection of primer-template sequences that bind human immunodeficiency virus reverse transcriptase with high affinity
2006 · J. J. DeStefano · Nucleic Acids Research · 47
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Selection of 2'-Deoxy-2'-Fluoroarabino Nucleic Acid (FANA) Aptamers that Bind HIV-1 Integrase with Picomolar Affinity
2019 · Kevin M. Rose, Irani Alves Ferreira-Bravo, et al. · ACS Chemical Biology · 45
Novel Aptamer Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase
2008 · Jeffrey J. Destefano, Gauri R. Nair · Oligonucleotides · 41
Poliovirus Protein 3AB Displays Nucleic Acid Chaperone and Helix-Destabilizing Activities
2006 · Jeffrey J. DeStefano, Oduyebo Titilope · Journal of Virology · 41
Evidence for the Differential Effects of Nucleocapsid Protein on Strand Transfer in Various Regions of the HIV Genome
2003 · Suchitra S. Derebail, Megan J. Heath, et al. · Journal of Biological Chemistry · 41
The orientation of binding of human immunodeficiency virus reverse transcriptase on nucleic acid hybrids
1995 · Jeffrey J. DeStefano · Nucleic Acids Research · 41
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Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis—Binding of Foscarnet
2016 · Kalyan Das, Jan Balzarini, et al. · ACS Chemical Biology · 40
Structure of HIV ‐1 reverse transcriptase bound to a novel 38‐mer hairpin template‐primer DNA aptamer
2015 · Matthew T. Miller, Steve Tuske, et al. · Protein Science · 39
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Interaction of Human Immunodeficiency Virus Nucleocapsid Protein with a Structure Mimicking a Replication Intermediate
1996 · Jeffrey J. DeStefano · Journal of Biological Chemistry · 39
Influence of sequence identity and unique breakpoints on the frequency of intersubtype HIV-1 recombination
2006 · Heather A Baird, Yong Gao, et al. · Retrovirology · 38
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Mutations in the Ribonuclease H Active Site of HIV−RT Reveal a Role for This Site in Stabilizing Enzyme−Primer−Template Binding
2002 · Jason V. Cristofaro, Jason W. Rausch, et al. · Biochemistry · 38
Interaction of human immunodeficiency virus nucleocapsid protein with a structure mimicking a replication intermediate. Effects on stability, reverse transcriptase binding, and strand transfer.
1996 · J J DeStefano · PubMed · 38
Works count: 99
Citation count: 2,302
H-index: 31
I10-index: 56
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