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Kiyohiro Hashimoto
Observed names:
Hashimoto, Kiyohiro,
K. Hashimoto,
Kiyohiro HASHIMOTO
Institutions:
Japan Pharmaceutical Manufacturers Association,
Takeda (Japan)
Observed institutions:
University of North Carolina at Chapel Hill,
Taisho Pharmaceutical (Japan),
Takeda (United States),
Japan Pharmaceutical Manufacturers Association,
Takeda (Japan)
ORCID:
0000-0003-4752-6950
Observed ORCID:
0000-0003-4752-6950
OpenAlex ID:
A5015239386
An in vitro micronucleus assay with size-classified micronucleus counting to discriminate aneugens from clastogens
2009
·
Kiyohiro Hashimoto
, Yumi Nakajima
, et al.
·
Toxicology in Vitro
·
75
Comparison of four different treatment conditions of extended exposure in the in vitro micronucleus assay using TK6 lymphoblastoid cells
2010
·
Kiyohiro Hashimoto
, Yumi Nakajima
, et al.
·
Regulatory Toxicology and Pharmacology
·
25
Mutations induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the lacZ and cII genes of Muta? Mouse
2004
·
Kiyohiro Hashimoto
, Koh-ichi Ohsawa
, et al.
·
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
·
25
Analysis of negative historical control group data from the in vitro micronucleus assay using TK6 cells
2017
·
David P. Lovell
, Mick Fellows
, et al.
·
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
·
16
PDF
Involvement of p53 function in different magnitude of genotoxic and cytotoxic responses in in vitro micronucleus assays
2011
·
Kiyohiro Hashimoto
, Yumi Nakajima
, et al.
·
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
·
14
Potential issues associated with the introduction of virtual control groups into non-clinical toxicology studies
2024
·
Gen SATO
, Mikio NAKAJIMA
, et al.
·
Translational and Regulatory Sciences
·
12
PDF
CDK8/19 inhibition plays an important role in pancreatic β-cell induction from human iPSCs
2023
·
Kensuke Sakuma
, Noriko Tsubooka-Yamazoe
, et al.
·
Stem Cell Research & Therapy
·
12
PDF
In vivo genotoxicity testing strategies: Report from the 8th International Workshop on Genotoxicity Testing ( IWGT )
2023
·
Carol Beevers
, Yoshifumi Uno
, et al.
·
Environmental and Molecular Mutagenesis
·
11
PDF
Mitotic slippage underlies the relationship between p53 dysfunction and the induction of large micronuclei by colcemid
2013
·
K. Hashimoto
, T. Todo
·
Mutagenesis
·
8
Difference in susceptibility to morphological changes in the nucleus to aneugens between p53-competent and p53-abrogated lymphoblastoid cell lines (TK6 and NH32 cells) in the in vitro micronucleus assay
2011
·
K. Hashimoto
, Y. Nakajima
, et al.
·
Mutagenesis
·
5
Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction inFANC-deficient cells
2016
·
Kiyohiro Hashimoto
, Vyom Sharma
, et al.
·
Oncotarget
·
4
PDF
Incorporation of metabolic activation potentiates cyclophosphamide-induced DNA damage response in isogenic DT40 mutant cells
2015
·
Kiyohiro Hashimoto
, Shunichi Takeda
, et al.
·
Mutagenesis
·
3
PDF
Interfacility variations in blood chemistry parameters and their implications for virtual control group construction
2025
·
Gen Sato
, Takao Kurooka
, et al.
·
NAM journal.
·
2
Local QSAR based on quantum chemistry calculations for the stability of nitrenium ions to reduce false positive outcomes from standard QSAR systems for the mutagenicity of primary aromatic amines
2024
·
Shigeharu Muto
, Ayako Furuhama
, et al.
·
Genes and Environment
·
2
PDF
Derivation of permitted daily exposure value for trifluoroacetic acid as an impurity in pharmaceutical products
2023
·
Hisakazu Sanada
, Tsukasa Kikuno
, et al.
·
Fundamental Toxicological Sciences
·
2
PDF
A comparison of the lowest effective concentration in culture media for detection of chromosomal damage in vitro and in blood or plasma for detection of micronuclei in vivo
2022
·
David Kirkland
, James Whitwell
, et al.
·
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
·
2
PDF
Analysis of historical negative control group data from the in vitro micronucleus assay using human lymphocytes
2018
·
David P. Lovell
, Mick Fellow
, et al.
·
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
·
2
PDF
A case study of virtual control group verification using historical control data at a single facility
2026
·
Yuichiro Amano
, Hideto Hara
, et al.
·
The Journal of Toxicological Sciences
·
1
PDF
Interpreting the statistical analysis results of a virtual control group in toxicity studies and potential applicability of an artificial synthetic control group
2026
·
Ikuro Takakura
, Gen Sato
, et al.
·
NAM journal.
Summary of Major Conclusions From the 8th International Workshop on Genotoxicity Testing ( IWGT ), Ottawa, Canada
2025
·
Hans‐Joerg Martus
, Carol Beevers
, et al.
·
Environmental and Molecular Mutagenesis
PDF
Differences in metabolite genotoxicity test results of rat liver S9 microsomes treated with various microsomal enzyme inducers
2025
·
Shigeru Igaki
, Kiyohiro Hashimoto
, et al.
·
Toxicology Mechanisms and Methods
PDF
Derivation of permitted daily exposure value for 1,8-diazabicyclo[5.4.0]undec-7-ene in pharmaceutical products
2023
·
Haruna Tahara
, Hisakazu Sanada
, et al.
·
Fundamental Toxicological Sciences
PDF
Derivation of the permitted daily exposure value for p-tert-butylphenol as an impurity in pharmaceutical products
2023
·
Yasuyuki Ohnishi
, Hisakazu Sanada
, et al.
·
Fundamental Toxicological Sciences
PDF
4-NQO-Induced Mutations in the lacZ Gene and Repair Pathways in Stationary Phase of Eschericida coli
1999
·
Kiyohiro Hashimoto
, Qiu-Mei Zhang
, et al.
·
Journal of Radiation Research
Stationary Phase Mutations that occur in lacZ gene in Escherichia coli and the role of DNA damage
1998
·
Kiyohiro Hashimoto
, Qiu-Mei Zhang
, et al.
·
Journal of Radiation Research
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Works count:
30
Citation count:
221
H-index:
8
I10-index:
8
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