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Alex G. S. Preston

Observed names: Alex G. Preston, Alex G.S. Preston, Alex Preston, Preston, Alex
ORCID: 0000-0003-0334-0679
Observed ORCID: 0000-0003-0334-0679
OpenAlex ID: A5015539344
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation
2020 · Omer Gilan, Inmaculada Rioja, et al. · Science · 459
The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor
2020 · Jonathan T. Seal, Stephen J. Atkinson, et al. · Journal of Medicinal Chemistry · 77
Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives
2016 · Susan M. Westaway, Alex G. S. Preston, et al. · Journal of Medicinal Chemistry · 72
Design and Synthesis of a Highly Selective and In Vivo -Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins
2020 · Alex Preston, Stephen Atkinson, et al. · Journal of Medicinal Chemistry · 66
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Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives
2016 · Susan M. Westaway, Alex G. S. Preston, et al. · Journal of Medicinal Chemistry · 64
Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor
2011 · John Liddle, Francis L. Atkinson, et al. · Bioorganic & Medicinal Chemistry Letters · 60
Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit
2021 · Francesco Rianjongdee, Stephen J. Atkinson, et al. · Journal of Medicinal Chemistry · 53
Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors
2021 · Helen E. Aylott, Stephen J. Atkinson, et al. · Journal of Medicinal Chemistry · 35
GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family
2020 · Alex Preston, Stephen J. Atkinson, et al. · ACS Medicinal Chemistry Letters · 34
Identification of a Series of N -Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins
2021 · Lee A. Harrison, Stephen J. Atkinson, et al. · Journal of Medicinal Chemistry · 30
Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors
2021 · Simon C. C. Lucas, Stephen J. Atkinson, et al. · Journal of Medicinal Chemistry · 28
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Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors
2021 · Jonathan T. Seal, Stephen J. Atkinson, et al. · Journal of Medicinal Chemistry · 28
Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate
2022 · Philip G. Humphreys, Stephen J. Atkinson, et al. · Journal of Medicinal Chemistry · 23
Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors
2016 · Neil S. Garton, Michael D. Barker, et al. · Bioorganic & Medicinal Chemistry Letters · 11
Multigram Synthesis of Tetrasubstituted Dihydrobenzofuran GSK973 Enabled by High-Throughput Experimentation and a Claisen Rearrangement in Flow
2022 · Catherine M. Alder, Matthew Gray, et al. · Organic Process Research & Development · 7
Design and Characterization of 1,3-Dihydro-2 H -benzo[ d ]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors
2023 · Paul Bamborough, Chun-wa Chung, et al. · ACS Medicinal Chemistry Letters · 6
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Discovery of Highly Potent BET Inhibitors based on a Tractable Tricyclic Scaffold
2025 · Jaffer M. Zaidi, Eleonora Comeo, et al. · ACS Medicinal Chemistry Letters · 5
BET Isoform Selectivity through Diverse Linkers for Bivalent Inhibitors: GSK785, a BRD2/4-Selective Bivalent BET Inhibitor
2025 · Francesco Rianjongdee, Stephen J. Atkinson, et al. · Journal of Medicinal Chemistry · 1
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Correction to “Multigram Synthesis of Tetrasubstituted Dihydrobenzofuran GSK973 Enabled by High-Throughput Experimentation and a Claisen Rearrangement in Flow”
2022 · Catherine M. Alder, Matthew Gray, et al. · Organic Process Research & Development
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CCDC 2001550: Experimental Crystal Structure Determination
2020 · Seal, Jonathan T., Atkinson, Stephen J., et al. · The Cambridge Structural Database
Works count: 20
Citation count: 1,059
H-index: 13
I10-index: 14
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