Author

John Dulos

Observed names: Dulos, John, J DULOS, J Dulos, JOHN DULOS, John Dulos (12568)

Institutions: SDS Biotech (Japan), Foundation Centrum '45

Observed institutions: Merck & Co., Inc., Rahway, NJ, USA (United States), University Medical Center Utrecht, SDS Biotech (Japan), Merck B.V. (Netherlands), Foundation Centrum '45, Johnson & Johnson (Netherlands), MSD (Netherlands), Communication cellulaire et MicroEnvironnement Tumoral, Organon (Netherlands), Wageningen University & Research

ORCID: 0009-0003-0928-9971

Observed ORCID: 0009-0003-0928-9971

OpenAlex ID: A5015564877

PD-1 Blockade Augments Th1 and Th17 and Suppresses Th2 Responses in Peripheral Blood From Patients With Prostate and Advanced Melanoma Cancer

2012 · John Dulos, Gregory J. Carven, et al. · Journal of Immunotherapy · 319

APRIL signaling via TACI mediates immunosuppression by T regulatory cells in multiple myeloma: therapeutic implications

2018 · Yu-Tzu Tai, Liang Lin, et al. · Leukemia · 90

CYP7B expression and activity in fibroblast‐like synoviocytes from patients with rheumatoid arthritis: Regulation by proinflammatory cytokines

2005 · John Dulos, Monique A. J. van der Vleuten, et al. · Arthritis & Rheumatism · 58

A potent and selective p38 inhibitor protects against bone damage in murine collagen‐induced arthritis: a comparison with neutralization of mouse TNFα

2008 · K Mihara, C Almansa, et al. · British Journal of Pharmacology · 51

Zigakibart demonstrates clinical safety and efficacy in a Phase 1/2 trial of healthy volunteers and patients with IgA nephropathy

2025 · Laura Kooienga, Jeannette Lo, et al. · Kidney International · 46

Therapeutic Antibody Targeting of CD97 in Experimental Arthritis: the Role of Antigen Expression, Shedding, and Internalization on the Pharmacokinetics of Anti-CD97 Monoclonal Antibody 1B2

2009 · Dorien M de Groot, Gerard Vogel, et al. · The Journal of Immunology · 44

Bacillus Calmette–Guérin-Induced Trained Immunity Is Not Protective for Experimental Influenza A/Anhui/1/2013 (H7N9) Infection in Mice

2018 · L. Charlotte J. de Bree, Renoud J. Marijnissen, et al. · Frontiers in Immunology · 40

Severity of murine collagen‐induced arthritis correlates with increased CYP7B activity: Enhancement of dehydroepiandrosterone metabolism by interleukin‐1β

2004 · John Dulos, Evert Verbraak, et al. · Arthritis & Rheumatism · 39

Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor α but not estrogen receptor β

2010 · John Dulos, Peter Vijn, et al. · Arthritis Research & Therapy · 35

T cell lessons from the rheumatoid arthritis synovium SCID mouse model: CD3‐rich synovium lacks response to CTLA‐4ig but is successfully treated by interleukin‐17 neutralization

2011 · Marije I. Koenders, Renoud J. Marijnissen, et al. · Arthritis & Rheumatism · 27

Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab

2020 · Beth Hutchins, Gary C. Starling, et al. · Molecular Cancer Therapeutics · 25

Origin of primordial germ cells, as characterized by the presence of nuage, in embryos of the teleost fish Barbus conchonius.

1992 · P Gevers, J Dulos, et al. · PubMed · 21

Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 inhibitors

2011 · Allard Kaptein, Arthur Oubrie, et al. · Bioorganic & Medicinal Chemistry Letters · 20

Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b

2005 · John Dulos, Allard Kaptein, et al. · Arthritis Research & Therapy · 19

Exposure to Candida albicans Polarizes a T-Cell Driven Arthritis Model towards Th17 Responses, Resulting in a More Destructive Arthritis

2012 · Renoud J. Marijnissen, Marije I. Koenders, et al. · PLoS ONE · 17

p38 inhibition and not MK2 inhibition enhances the secretion of chemokines from TNF-α activated rheumatoid arthritis fibroblast-like synoviocytes.

2013 · J Dulos, F P G Wijnands, et al. · PubMed · 16

DHEA Metabolism in Arthritis: A Role for the p450 Enzyme Cyp7b at the Immune–Endocrine Crossroad

2006 · JOHN DULOS, ANNEMIEKE H. BOOTS · Annals of the New York Academy of Sciences · 13

A study on cell lineage, especially the germ cell line, in embryos of the teleost fish,Barbus conchonius

1992 · Petra Gevers, John Dulos, et al. · Development Genes and Evolution · 9

ADAMTS-5 inhibition reduces muscle inflammation and fibrosis and improves function in mouse models of Duchenne muscular dystrophy

2025 · John Dulos, Danielle A. Debruin, et al. · Science Translational Medicine · 5

APRIL Is Significantly Elevated at All Stages of Multiple Myeloma (MM) and Interferes with Anti-Bcma Monoclonal Antibody-Mediated Cytolysis, Supporting the Clinical Evaluation of Bion-1301 As a Novel Therapeutic Approach in MM

2018 · Yu-Tzu Tai, John Dulos, et al. · Blood · 5

A selective estrogen receptor alpha agonist (ORG 37663) suppresses inflammation and arthritis in mouse models

2006 · John Dulos, Claudia L. Hofstra, et al. · University of Groningen research database (University of Groningen / Centre for Information Technology) · 4

Corrigendum: Bacillus Calmette–Guérin-Induced Trained Immunity Is Not Protective for Experimental Influenza A/Anhui/1/2013 (H7N9) Infection in Mice

2018 · L. Charlotte J. de Bree, Renoud J. Marijnissen, et al. · Frontiers in Immunology · 3

Abstract 2645: Development of a first in class APRIL fully blocking antibody BION-1301 for the treatment of multiple myeloma

2017 · John Dulos, Lilian Driessen, et al. · Cancer Research · 3

Bion-1301: A Novel Fully Blocking APRIL Antibody for the Treatment of Multiple Myeloma

2016 · John Dulos, Driessen Lilian, et al. · Blood · 3

Zigakibart Potently Inhibits A Proliferation-Inducing Ligand-Mediated IgA Production, Addressing IgAN Pathogenesis Root Causes

2026 · John Dulos, Joost Kreijtz, et al. · Kidney International Reports · 2

Works count: 42

Citation count: 916

H-index: 16

I10-index: 17