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Simon Andrew Hirota

Observed names: Hirota, Simon, Hirota, Simon A., S A Hirota, S Hirota, S. A. Hirota, S. Hirota, S.A. Hirota, Simon A Hirota, Simon A. Hirota, Simon Hirota
Observed institutions: Albert Einstein College of Medicine, University of British Columbia, University of Calgary, Weill Cornell Medical College in Qatar, Weill Cornell Medicine, Alberta Children's Hospital Research Institute, Libin Cardiovascular Institute of Alberta, St. Joseph’s Healthcare Hamilton, Jamia Millia Islamia, McMaster University
ORCID: 0000-0001-5782-1481
Observed ORCID: 0000-0001-5782-1481
OpenAlex ID: A5015809675
Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation
2010 · Braedon McDonald, Keir Pittman, et al. · Science · 1,206
The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD
2010 · Akosua Vilaysane, Justin Chun, et al. · Journal of the American Society of Nephrology · 587
Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis
2012 · Brian D Gulbransen, Mohammad Bashashati, et al. · Nature Medicine · 443
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
2010 · Simon A. Hirota, Jeffrey Ng, et al. · Inflammatory Bowel Diseases · 433
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Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia
2021 · Fernando A. Vicentini, Catherine M. Keenan, et al. · Microbiome · 327
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Clostridium difficile Toxin–Induced Inflammation and Intestinal Injury Are Mediated by the Inflammasome
2010 · Jeffrey Ng, Simon A. Hirota, et al. · Gastroenterology · 259
The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin‐1β
2012 · Nathan A. Bracey, Paul L. Beck, et al. · Experimental Physiology · 188
The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter
2012 · Jeremy A. Hirota, Simon A. Hirota, et al. · Journal of Allergy and Clinical Immunology · 161
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IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria
2016 · K.L. Flannigan, V.L. Ngo, et al. · Mucosal Immunology · 140
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Vancomycin relieves mycophenolate mofetil–induced gastrointestinal toxicity by eliminating gut bacterial β-glucuronidase activity
2019 · Michael R. Taylor, Kyle L. Flannigan, et al. · Science Advances · 121
Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress
2018 · Mahmoud El-Daly, Vivek Krishna Pulakazhi Venu, et al. · Vascular Pharmacology · 116
Mechanisms of hydrogen‐peroxide‐induced biphasic response in rat mesenteric artery
2003 · Yu‐Jing Gao, Simon Hirota, et al. · British Journal of Pharmacology · 112
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Hypoxia-Inducible Factor Signaling Provides Protection in Clostridium difficile-Induced Intestinal Injury
2010 · Simon A. Hirota, Kyla Fines, et al. · Gastroenterology · 101
The Pregnane X Receptor and Indole-3-Propionic Acid Shape the Intestinal Mesenchyme to Restrain Inflammation and Fibrosis
2022 · Kyle L. Flannigan, Kristoff M. Nieves, et al. · Cellular and Molecular Gastroenterology and Hepatology · 95
Ionic mechanisms and Ca2+handling in airway smooth muscle
2007 · S. Hirota, P. Helli, et al. · European Respiratory Journal · 91
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An intact microbiota is required for the gastrointestinal toxicity of the immunosuppressant mycophenolate mofetil
2018 · Kyle L. Flannigan, Michael R. Taylor, et al. · The Journal of Heart and Lung Transplantation · 89
The roles of host and pathogen factors and the innate immune response in the pathogenesis of Clostridium difficile infection
2014 · Xingmin Sun, Simon A. Hirota · Molecular Immunology · 87
Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis
2014 · Joshua Terc, Ashleigh Hansen, et al. · European Journal of Pharmaceutical Sciences · 87
Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation
2016 · Aditya Garg, Angela Zhao, et al. · Journal of Pharmacology and Experimental Therapeutics · 82
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The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation
2019 · Vivek Krishna Pulakazhi Venu, Mahmoud Saifeddine, et al. · American Journal of Physiology-Endocrinology and Metabolism · 78
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Targeting the pregnane X receptor using microbial metabolite mimicry
2020 · Zdeněk Dvořák, Felix Kopp, et al. · EMBO Molecular Medicine · 77
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Giardia duodenalis Infection Reduces Granulocyte Infiltration in an In Vivo Model of Bacterial Toxin-Induced Colitis and Attenuates Inflammation in Human Intestinal Tissue
2014 · James A. Cotton, Jean-Paul Motta, et al. · PLoS ONE · 77
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The reverse mode of the Na+/Ca2+ exchanger provides a source of Ca2+ for store refilling following agonist-induced Ca2+ mobilization
2006 · Simon Hirota, Evi Pertens, et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 68
Colitis-Induced Microbial Perturbation Promotes Postinflammatory Visceral Hypersensitivity
2020 · Nicolas Esquerre, Lilian Basso, et al. · Cellular and Molecular Gastroenterology and Hepatology · 64
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Inflammatory Bowel Disease Cause-specific Mortality
2014 · Zain Kassam, Sara Belga, et al. · Inflammatory Bowel Diseases · 58
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Works count: 170
Citation count: 6,447
H-index: 36
I10-index: 67
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