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Heng Ru

AARS1 and AARS2 sense l-lactate to regulate cGAS as global lysine lactyltransferases
2024 · Heyu Li, Chao Liu, et al. · Nature · 408
Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding
2012 · Songying Ouyang, Xianqiang Song, et al. · Immunity · 350
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Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures
2015 · Heng Ru, Melissa G. Chambers, et al. · Cell · 191
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Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity
2024 · Pietro Fontana, Gang Du, et al. · Cell · 125
Characterization of T and B cell repertoire diversity in patients with RAG deficiency
2016 · Yu Nee Lee, Francesco Frugoni, et al. · Science Immunology · 116
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity
2022 · Ziran Qin, Xiuwu Fang, et al. · Nature Immunology · 113
Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage
2014 · Lixia Zhao, Tian Hua, et al. · Cell Research · 102
Targeting FOXM1 condensates reduces breast tumour growth and metastasis
2025 · Feng Xie, Xiaoxue Zhou, et al. · Nature · 95
Crystal structure of the WD40 domain dimer of LRRK2
2019 · Pengfei Zhang, Ying Fan, et al. · Proceedings of the National Academy of Sciences · 93
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DNA melting initiates the RAG catalytic pathway
2018 · Heng Ru, Wei Mi, et al. · Nature Structural & Molecular Biology · 57
New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16
2015 · Xiangmin Ni, Heng Ru, et al. · Journal of Molecular Cell Biology · 50
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Structural basis for termination of AIM2-mediated signaling by p202
2013 · Heng Ru, Xiangmin Ni, et al. · Cell Research · 45
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Structural biology and functional features of phage-derived depolymerase Depo32 on Klebsiella pneumoniae with K2 serotype capsular polysaccharides
2023 · Ruopeng Cai, Zhuolu Ren, et al. · Microbiology Spectrum · 32
Structural gymnastics of RAG-mediated DNA cleavage in V(D)J recombination
2018 · Heng Ru, Pengfei Zhang, et al. · Current Opinion in Structural Biology · 30
S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS
2012 · Heng Ru, Lixia Zhao, et al. · Acta Crystallographica Section D Biological Crystallography · 26
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Structural biology study of human TNF receptor associated factor 4 TRAF domain
2013 · Fengfeng Niu, Heng Ru, et al. · Protein & Cell · 20
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Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures
2015 · Heng Ru, Melissa G. Chambers, et al. · Cell · 16
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Structural insights into the RNA-dependent RNA polymerase complexes from highly pathogenic Marburg and Ebola viruses
2025 · Guobao Li, Tianjiao Du, et al. · Nature Communications · 11
Cryo-EM structure of an activated GPR4–Gs signaling complex
2025 · Yitong Ma, Yijie Wang, et al. · Nature Communications · 11
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Structural insights into cholesterol transport and hydrolase activity of a putative human RNA transport protein SIDT1
2024 · Wenxia Liu, Mengyuan Tang, et al. · Cell Discovery · 5
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Thermus thermophilus-derived protein tags that aid in preparation of insoluble viral proteins
2008 · Naoyuki Kondo, Akio Ebihara, et al. · Analytical Biochemistry · 4
Promiscuity Is Not Always Bad
2014 · Heng Ru, Pengfei Zhang, et al. · Molecular Cell · 3
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Structural insights into measles virus RNA synthesis regulation and pan-paramyxoviral polymerase inhibition by ERDRP-0519
2026 · Tianjiao Du, Jiening Wang, et al. · Proceedings of the National Academy of Sciences · 2
Crystal structure of LRRK2 WD40 domain dimer
2018 · P. Zhang, H. Ru, et al. · Worldwide Protein Data Bank · 2
Structural insight into the activation of adenosine A2AR/A2BR by the dual-agonist MRS3997
2026 · Yuan Weng, Matteo Pavan, et al. · Communications Biology
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Works count: 43
Citation count: 1,906
H-index: 16
I10-index: 19
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