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Sascha Young Kupke

Observed names: Kupke, S., Kupke, Sascha Y., Kupke, Sascha Young, S.Y. Kupke, Sascha Young Kupke, Sascha Kupke, Sascha Y. Kupke
ORCID: 0000-0003-3943-9718
Observed ORCID: 0000-0003-3943-9718
OpenAlex ID: A5016107448
Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infection
2015 · Frank S. Heldt, Sascha Y. Kupke, et al. · Nature Communications · 182
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Influenza virus intracellular replication dynamics, release kinetics, and particle morphology during propagation in MDCK cells
2016 · Timo Frensing, Sascha Y. Kupke, et al. · Applied Microbiology and Biotechnology · 71
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A Novel Type of Influenza A Virus-Derived Defective Interfering Particle with Nucleotide Substitutions in Its Genome
2018 · Sascha Young Kupke, Dietmar Riedel, et al. · Journal of Virology · 47
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Multiscale modeling of influenza A virus replication in cell cultures predicts infection dynamics for highly different infection conditions
2019 · Daniel Rüdiger, Sascha Young Kupke, et al. · PLoS Computational Biology · 44
Antiviral Activity of Influenza A Virus Defective Interfering Particles against SARS-CoV-2 Replication In Vitro through Stimulation of Innate Immunity
2021 · U. Rand, S.Y. Kupke, et al. · Cells · 39
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Semi-continuous Propagation of Influenza A Virus and Its Defective Interfering Particles: Analyzing the Dynamic Competition To Select Candidates for Antiviral Therapy
2021 · Lars Pelz, Daniel Rüdiger, et al. · Journal of Virology · 36
OP7, a novel influenza A virus defective interfering particle: production, purification, and animal experiments demonstrating antiviral potential
2020 · Marc D. Hein, Heike Kollmus, et al. · Applied Microbiology and Biotechnology · 33
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Cell culture–based production of defective interfering influenza A virus particles in perfusion mode using an alternating tangential flow filtration system
2021 · Marc D. Hein, Anshika Chawla, et al. · Applied Microbiology and Biotechnology · 29
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Cell culture-based production and in vivo characterization of purely clonal defective interfering influenza virus particles
2021 · Marc D. Hein, Prerna Arora, et al. · BMC Biology · 29
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Single-Cell Analysis Uncovers a Vast Diversity in Intracellular Viral Defective Interfering RNA Content Affecting the Large Cell-to-Cell Heterogeneity in Influenza A Virus Replication
2020 · Sascha Young Kupke, Lam-Ha Ly, et al. · Viruses · 25
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Broad-Spectrum Antiviral Activity of Influenza A Defective Interfering Particles against Respiratory Syncytial, Yellow Fever, and Zika Virus Replication In Vitro
2023 · Lars Pelz, Elena Piagnani, et al. · Viruses · 18
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Multiscale model of defective interfering particle replication for influenza A virus infection in animal cell culture
2021 · Daniel Rüdiger, Lars Pelz, et al. · PLoS Computational Biology · 17
Absolute quantification of viral proteins during single-round replication of MDCK suspension cells
2022 · Jan Küchler, Sebastian Püttker, et al. · Journal of Proteomics · 11
Generation of “OP7 chimera” defective interfering influenza A particle preparations free of infectious virus that show antiviral efficacy in mice
2023 · Tanya Dogra, Lars Pelz, et al. · Scientific Reports · 10
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Production of retroviral vectors in continuous high cell density culture
2023 · Marc D. Hein, Daniel Kazenmaier, et al. · Applied Microbiology and Biotechnology · 10
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Mathematical model calibrated to in vitro data predicts mechanisms of antiviral action of the influenza defective interfering particle “OP7”
2024 · Daniel Rüdiger, Julita Piasecka, et al. · iScience · 5
Production of antiviral “OP7 chimera” defective interfering particles free of infectious virus
2024 · Lars Pelz, Tanya Dogra, et al. · Applied Microbiology and Biotechnology · 2
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Prophylactic and therapeutic antiviral effects of the influenza A defective interfering particle OP7 in human lung epithelial cells in vitro
2026 · Patricia Opitz, Jan Küchler, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
Data-Driven Multiscale Modeling Deciphers MOI-Dependent Dual Antiviral Mechanisms of OP7
2026 · Daniel Rüdiger, Patricia Opitz, et al. · SSRN Electronic Journal · 1
Fed-batch production of antiviral „OP7 chimera” defective interfering influenza A particles
2026 · Wiebke Holste, Sascha Y. Kupke, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Model-Guided Engineering of NS1-Truncated Influenza OP7 Particles with Enhanced Interferon-Mediated Antiviral Activity
2026 · Julita Piasecka, Daniel Rüdiger, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Semi-continuous propagation of influenza A virus and its defective interfering particles - analyzing the dynamic competition to select antiviral candidates
2021 · Lars Pelz, Daniel Rüdiger, et al.
Multiscale model of influenza A virus and defective interfering particle co-infection in animal cell culture
2021 · Daniel Rüdiger, Lars Pelz, et al.
Evolution and selection of influenza a virus defective interfering particles in a semi-continuous production system for the use as antiviral
2020 · Lars Pelz, Daniel Rüdiger, et al.
The novel influenza A virus defective interfering particle "OP7" as an antiviral agent: discovery, production, and animal trials
2020 · Sascha Young Kupke, Marc D. Hein, et al. · MPG.PuRe (Max Planck Society)
Works count: 43
Citation count: 612
H-index: 12
I10-index: 15
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