Author

Hiroto Iwai

Observed name: H. Iwai

Institution: Kyowa Kirin (Japan)

Observed institutions: Horiba (Japan), Kyowa Kirin (Japan), Japan Science and Technology Agency, The University of Tokyo

ORCID: 0009-0008-8781-3077

Observed ORCID: 0009-0008-8781-3077

OpenAlex ID: A5016148236

Targeted delivery to macrophages and dendritic cells by chemically modified mannose ligand-conjugated siRNA

2022 · Keiji Uehara, Toshimasa Harumoto, et al. · Nucleic Acids Research · 80

Antibody affinity maturation in vitro using unconjugated peptide antigen

2010 · Hiroto Iwai, Bengü Öztürk, et al. · Protein Engineering Design and Selection · 20

Simplifying the Chemical Structure of Cationic Lipids for siRNA-Lipid Nanoparticles

2019 · Takeshi Kuboyama, Kaori Yagi, et al. · ACS Medicinal Chemistry Letters · 19

Enhancement of Gene Knockdown on CD22-Expressing Cells by Chemically Modified Glycan Ligand–siRNA Conjugates

2022 · Toshimasa Harumoto, Hiroto Iwai, et al. · ACS Chemical Biology · 18

Position-specific ORF nucleoside-ribose modifications enabled by complete chemical synthesis enhance mRNA stability and translation

2025 · Hiroto Iwai, Yasuaki Kimura, et al. · Nature Communications · 9

Position-Specific Nucleoside Sugar Modifications in mRNA ORF: Enhancing Translational Function through Complete Chemical Synthesis of mRNA

2024 · Hiroto Iwai, Yasuaki Kimura, et al. · ChemRxiv · 7

Creation of a Ligand-Dependent Enzyme by Fusing Circularly Permuted Antibody Variable Region Domains

2016 · Hiroto Iwai, Miki Kojima-Misaizu, et al. · Bioconjugate Chemistry · 7

Activation of Circularly Permutated β-Lactamase Tethered to Antibody Domains by Specific Small Molecules

2011 · Miki Kojima, Hiroto Iwai, et al. · Bioconjugate Chemistry · 6

Concise Affinity‐Based Purification of Ligated mRNA for Structure‐Activity Relationship Studies of Nucleosugar Modification Patterns

2024 · Hiroki Yamada, Hiroto Iwai, et al. · ChemBioChem · 2

Author response for "Characterization of Nuclease Stability and Poly(A)-binding Protein Binding Activity of Chemically Modified Poly(A) Tail for in vivo Applications†"

2025 · Atsushi Hashimoto, Hiroto Iwai, et al. · Publons reviews and discussion

Creation of Antigen-Dependent β-Lactamase Fusion Protein Tethered by Circularly Permuted Antibody Variable Domains

2017 · Hiroto Iwai, Miki Kojima-Misaizu, et al. · Methods in molecular biology

Noncompetitive Detection of Low Molecular Weight Peptides by Open Sandwich Immunoassay

2008 · H. Ueda, S. Lim, et al. · Journal of Proteomics & Bioinformatics

Works count: 12

Citation count: 168

H-index: 7

I10-index: 4