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Adrian Lloyd Smith

Observed names: A L Smith, A Smith, A. L. SMITH, A. L. Smith, A. Smith, A.L. Smith, Adrian L Smith, Adrian L. Smith, Adrian Smith
Observed institutions: Scripps Research Institute, BC Cancer Agency, The University of Sydney, Amgen (United States), University of Miami, Provincial Health Services Authority, York University, University of Cambridge, Royal Prince Alfred Hospital, Centenary Institute, Calderdale and Huddersfield NHS Foundation Trust, University of California San Diego, University of Warwick, University of Oxford, MSD (UK) Limited (United Kingdom), Scripps Clinic, Drexel University, Columbia University, Cardiff University
ORCID: 0000-0002-0505-0344
Observed ORCID: 0000-0002-0505-0344
OpenAlex ID: A5016729281
Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
2000 · Yue-Ming Li, Min Xu, et al. · Nature · 870
Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems
2021 · Shahar Alon, Daniel R. Goodwin, et al. · Science · 428
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The Enediyne Antibiotics
1996 · Adrian L. Smith, K. C. Nicolaou · Journal of Medicinal Chemistry · 384
L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase Activity
2000 · Mark S. Shearman, Dirk Beher, et al. · Biochemistry · 360
Imaging mass cytometry and multiplatform genomics define the phenogenomic landscape of breast cancer
2020 · H. Raza Ali, Hartland W. Jackson, et al. · Nature Cancer · 314
Chemistry and biology of natural and designed enediynes.
1993 · K C Nicolaou, A L Smith, et al. · Proceedings of the National Academy of Sciences · 260
Molecular design, chemical synthesis, and biological action of enediynes
1992 · Kyriacos C. Nicolaou, Adrian L. Smith · Accounts of Chemical Research · 234
Three-dimensional imaging mass cytometry for highly multiplexed molecular and cellular mapping of tissues and the tumor microenvironment
2021 · Laura Kuett, Raúl Catena, et al. · Nature Cancer · 225
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Visualizing the Neutrophil Response to Sterile Tissue Injury in Mouse Dermis Reveals a Three-Phase Cascade of Events
2011 · Lai Guan Ng, Jim S. Qin, et al. · Journal of Investigative Dermatology · 224
Integration, exploration, and analysis of high‐dimensional single‐cell cytometry data using Spectre
2021 · Thomas Myles Ashhurst, Felix Marsh‐Wakefield, et al. · Cytometry Part A · 166
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Total synthesis of calicheamicin .gamma.1I. 1. Synthesis of the oligosaccharide fragment
1993 · R. D. Groneberg, T. Miyazaki, et al. · Journal of the American Chemical Society · 146
Total synthesis of calicheamicin .gamma.1I. 3. The final stages
1993 · K. C. Nicolaou, C. W. Hummel, et al. · Journal of the American Chemical Society · 131
Total synthesis of calicheamicin .gamma.1I
1992 · K. C. Nicolaou, C. W. Hummel, et al. · Journal of the American Chemical Society · 129
Total synthesis of calicheamicin .gamma.1I. 2. Development of an enantioselective route to (-)-calicheamicinone
1993 · A. L. Smith, E. N. Pitsinos, et al. · Journal of the American Chemical Society · 114
Stereoselective synthesis of (.+-.)-indolizidines 167B, 205A, and 207A. Enantioselective synthesis of (-)-indolizidine 209B
1991 · Andrew B. Holmes, Adrian L. Smith, et al. · The Journal of Organic Chemistry · 112
Selective Inhibitors of the Mutant B-Raf Pathway: Discovery of a Potent and Orally Bioavailable Aminoisoquinoline
2009 · Adrian L. Smith, Frenel F. DeMorin, et al. · Journal of Medicinal Chemistry · 104
Synthesis of dynemicin A models
1990 · K. C. Nicolaou, C. K. Hwang, et al. · Journal of the American Chemical Society · 98
Synthesis and chemistry of dynemicin A models
1991 · K. C. Nicolaou, A. L. Smith, et al. · Journal of the American Chemical Society · 95
Discovery of 1H-Pyrazol-3(2H)-ones as Potent and Selective Inhibitors of Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK)
2015 · Adrian L. Smith, Kristin L. Andrews, et al. · Journal of Medicinal Chemistry · 91
2-Aryl tryptamines: selective high-affinity antagonists for the h5-HT2A receptor
2000 · Graeme I Stevenson, Adrian L Smith, et al. · Bioorganic & Medicinal Chemistry Letters · 85
Enantioselective total synthesis of (-)-calicheamicinone
1992 · A. L. Smith, C. K. Hwang, et al. · Journal of the American Chemical Society · 82
Reverse Cope Elimination of Hydroxylamines and Alkenes or Alkynes: Theoretical Investigation of Tether Length and Substituent Effects
2012 · Elizabeth H. Krenske, Edwin C. Davison, et al. · Journal of the American Chemical Society · 80
Selective and Potent Raf Inhibitors Paradoxically Stimulate Normal Cell Proliferation and Tumor Growth
2010 · Josette Carnahan, Pedro J. Beltran, et al. · Molecular Cancer Therapeutics · 78
Traceless solid phase synthesis of 2,3-disubstituted indoles
1998 · Adrian L. Smith, Graeme I. Stevenson, et al. · Tetrahedron Letters · 73
An efficient solid phase synthetic route to 1,3-disubstituted 2,4(1H,3H)-Quinazolinediones suitable for combinatorial synthesis
1996 · Adrian L. Smith, Christopher G. Thomson, et al. · Bioorganic & Medicinal Chemistry Letters · 67
Works count: 105
Citation count: 6,111
H-index: 39
I10-index: 56
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