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Ngee Kiat Chua

Observed names: Chua, Ngee Kiat, N. K. Chua, Ngee K. Chua
ORCID: 0000-0003-2785-2767
Observed ORCID: 0000-0003-2785-2767
OpenAlex ID: A5016985970
Reduction of Squalene Epoxidase by Cholesterol Accumulation Accelerates Colorectal Cancer Progression and Metastasis
2020 · Soo Young Jun, Andrew J. Brown, et al. · Gastroenterology · 158
Squalene monooxygenase: a journey to the heart of cholesterol synthesis
2020 · Ngee Kiat Chua, Hudson W. Coates, et al. · Progress in Lipid Research · 112
A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate
2020 · Hiromasa Yoshioka, Hudson W. Coates, et al. · Proceedings of the National Academy of Sciences · 86
Caspase‐8‐driven apoptotic and pyroptotic crosstalk causes cell death and IL‐1β release in X‐linked inhibitor of apoptosis (XIAP) deficiency
2023 · Sebastian A Hughes, Meng Lin, et al. · The EMBO Journal · 74
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The shape of human squalene epoxidase expands the arsenal against cancer
2019 · Andrew J. Brown, Ngee Kiat Chua, et al. · Nature Communications · 72
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Cholesterol homeostasis: How do cells sense sterol excess?
2016 · Vicky Howe, Laura J. Sharpe, et al. · Chemistry and Physics of Lipids · 69
A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis
2017 · Ngee Kiat Chua, Vicky Howe, et al. · Journal of Biological Chemistry · 68
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The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change
2015 · Vicky Howe, Ngee Kiat Chua, et al. · Journal of Biological Chemistry · 47
Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase
2019 · Ngee Kiat Chua, Gene Hart-Smith, et al. · Journal of Biological Chemistry · 45
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Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms
2022 · Christoph Grohmann, Charlene M. Magtoto, et al. · Nature Communications · 42
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Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin
2022 · Gwo Yaw Ho, Elizabeth L. Kyran, et al. · Cancer Research · 26
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The E3-ome gene-centric compendium reveals the human E3 ligase landscape
2026 · Ngee Kiat Chua, Tania J. González-Robles, et al. · Cell · 24
Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24‐dehydrocholesterol reductase
2020 · P. Simonen, S. Li, et al. · Journal of Internal Medicine · 20
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Cholesterol, cancer, and rebooting a treatment for athlete’s foot
2018 · Ngee Kiat Chua, Hudson W. Coates, et al. · Science Translational Medicine · 15
Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene
2019 · Hudson W. Coates, Ngee Kiat Chua, et al. · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 14
Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron
2019 · Ngee Kiat Chua, Nicola A. Scott, et al. · Biochemical Journal · 11
The benchmarking and application of tag-degraders in vivo to validate therapeutic targets
2026 · Charlene M. Magtoto, Stephen Mieruszynski, et al. · Nature Communications · 4
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Mallostery: Filling a niche between quality and metabolic control
2018 · Ngee Kiat Chua, Andrew J. Brown · Journal of Biological Chemistry · 4
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The Degron Architecture of Squalene Monooxygenase and How Specific Lipids Calibrate Levels of This Key Cholesterol Synthesis Enzyme
2020 · Ngee Kiat Chua, Andrew J. Brown · Advances in experimental medicine and biology · 3
Efferocytosis of apoptotic bodies drives SARS-CoV-2 infection and macrophage inflammation
2026 · Thanh Kha Phan, Dylan Sheerin, et al. · Nature Communications · 2
INTS12 Bridges Integrator and NELF to Prevent the Release of Non-processive RNA Polymerase II Complexes
2026 · Laura D Corso, Isela Sarahi Rivera, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
Lipids Meet Immunity: Metabolic Control of cGAS-STING
2026 · Chui Yan Mah, Xuan Yuan Aw, et al. · Lipidology
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Supplementary Data from Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin
2025 · Gwo Yaw Ho, Elizabeth L. Kyran, et al.
Supplementary Data from Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin
2025 · Gwo Yaw Ho, Elizabeth L. Kyran, et al.
Data from Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin
2023 · Gwo Yaw Ho, Elizabeth L. Kyran, et al.
Works count: 42
Citation count: 897
H-index: 14
I10-index: 16
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