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Patrick C. Fraering

Observed names: Fraering, P., Fraering, Patrick, Fraering, Patrick C, Fraering, Patrick C., Patrick C Fraering, Patrick Fraering, Patrick C. Fraering
Observed institutions: University of Geneva, Brigham and Women's Hospital, Harvard University, University of Fribourg, École Polytechnique Fédérale de Lausanne, European Organization for Nuclear Research, Icahn School of Medicine at Mount Sinai
ORCID: 0000-0002-5841-5327
Observed ORCID: 0000-0002-5841-5327
OpenAlex ID: A5017201073
Substrate-targeting γ-secretase modulators
2008 · Thomas L. Kukar, Thomas B. Ladd, et al. · Nature · 280
Purification and Characterization of the Human γ-Secretase Complex
2004 · Patrick C. Fraering, Wenjuan Ye, et al. · Biochemistry · 226
Assembly of the γ-Secretase Complex Involves Early Formation of an Intermediate Subcomplex of Aph-1 and Nicastrin
2003 · Matthew J. LaVoie, Patrick C. Fraering, et al. · Journal of Biological Chemistry · 210
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Electron microscopic structure of purified, active γ-secretase reveals an aqueous intramembrane chamber and two pores
2006 · Vlado K. Lazarov, Patrick C. Fraering, et al. · Proceedings of the National Academy of Sciences · 161
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Detergent-Dependent Dissociation of Active γ-Secretase Reveals an Interaction between Pen-2 and PS1-NTF and Offers a Model for Subunit Organization within the Complex
2003 · Patrick C. Fraering, Matthew J. LaVoie, et al. · Biochemistry · 127
Cryoelectron Microscopy Structure of Purified γ-Secretase at 12 Å Resolution
2008 · Pamela Osenkowski, Hua Li, et al. · Journal of Molecular Biology · 116
The GPI Transamidase Complex ofSaccharomyces cerevisiaeContains Gaa1p, Gpi8p, and Gpi16p
2001 · Patrick Fraering, Isabella Imhof, et al. · Molecular Biology of the Cell · 111
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γ-Secretase Substrate Selectivity Can Be Modulated Directly via Interaction with a Nucleotide-binding Site
2005 · Patrick C. Fraering, Wenjuan Ye, et al. · Journal of Biological Chemistry · 100
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Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production
2017 · Hermeto Gerber, Fang Wu, et al. · Journal of Biological Chemistry · 90
Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production
2013 · Mitko Dimitrov, Jean-René Alattia, et al. · Nature Communications · 90
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A Compressible Scaffold for Minimally Invasive Delivery of Large Intact Neuronal Networks
2014 · Amélie Béduer, Thomas Braschler, et al. · Advanced Healthcare Materials · 85
Processing of the Synaptic Cell Adhesion Molecule Neurexin-3β by Alzheimer Disease α- and γ-Secretases
2010 · Nathalie Bot, Claude Schweizer, et al. · Journal of Biological Chemistry · 81
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Alzheimer's Disease-Linked Mutations in Presenilin-1 Result in a Drastic Loss of Activity in Purified γ-Secretase Complexes
2012 · Matthias Cacquevel, Lorène Aeschbach, et al. · PLoS ONE · 75
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The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease
2018 · Susanne Walter, Thorsten Jumpertz, et al. · Acta Neuropathologica · 64
Inactivation of brain Cofilin-1 by age, Alzheimer's disease and γ-secretase
2014 · Eugenio Barone, Sebastien Mosser, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 62
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Discovery of a Novel Pharmacological and Structural Class of Gamma Secretase Modulators Derived from the Extract of Actaea racemosa
2012 · Mark A. Findeis, Frank Schroeder, et al. · ACS Chemical Neuroscience · 61
A Simple and Reliable PDMS and SU-8 Irreversible Bonding Method and Its Application on a Microfluidic-MEA Device for Neuroscience Research
2015 · Yufei Ren, Shun-Ho Huang, et al. · Micromachines · 60
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Label-Free Imaging of Cerebral β-Amyloidosis with Extended-Focus Optical Coherence Microscopy
2012 · Tristan Bolmont, Arno Bouwens, et al. · Journal of Neuroscience · 56
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The Alzheimer’s Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides
2017 · Gabriele Siegel, Hermeto Gerber, et al. · Cell Reports · 53
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Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence
2016 · Ajinkya Revandkar, Maria Luna Perciato, et al. · Nature Communications · 50
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Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells
2016 · Yinzhong Lu, Jun Wan, et al. · The FASEB Journal · 48
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The Role of γ-Secretase Activating Protein (GSAP) and Imatinib in the Regulation of γ-Secretase Activity and Amyloid-β Generation
2012 · Ishrut Hussain, Julien Fabrègue, et al. · Journal of Biological Chemistry · 45
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Rapid purification of active γ‐secretase, an intramembrane protease implicated in Alzheimer’s disease
2007 · Matthias Cacquevel, Lorene Aeschbach, et al. · Journal of Neurochemistry · 41
Perturbations of the Straight Transmembrane α-Helical Structure of the Amyloid Precursor Protein Affect Its Processing by γ-Secretase
2014 · Thomas Lemmin, Mitko Dimitrov, et al. · Journal of Biological Chemistry · 39
Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells
2014 · Aleksandra Filipović, Ylenia Lombardo, et al. · Breast Cancer Research and Treatment · 37
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Works count: 73
Citation count: 2,800
H-index: 31
I10-index: 41
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