Author

Georgette M. Castanedo

Observed names: Castanedo, Georgette M., Georgette Castanedo, Georgette M Castanedo

Institution: Genentech

Observed institution: Genentech

ORCID: 0000-0003-4584-6715

Observed ORCID: 0000-0003-4584-6715

OpenAlex ID: A5018372628

GDC-0449—A potent inhibitor of the hedgehog pathway

2009 · Kirk D. Robarge, Shirley A. Brunton, et al. · Bioorganic & Medicinal Chemistry Letters · 395

Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton’s Tyrosine Kinase Inhibitor in Early Clinical Development

2018 · James J. Crawford, Adam R. Johnson, et al. · Journal of Medicinal Chemistry · 264

Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer

2011 · Daniel P. Sutherlin, Linda Bao, et al. · Journal of Medicinal Chemistry · 224

Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer

2010 · Daniel P. Sutherlin, Deepak Sampath, et al. · Journal of Medicinal Chemistry · 137

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus

2018 · Hans D. Brightbill, Eric Suto, et al. · Nature Communications · 132

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Rapid Synthesis of 1,3,5-Substituted 1,2,4-Triazoles from Carboxylic Acids, Amidines, and Hydrazines

2011 · Georgette M. Castanedo, Pamela S. Seng, et al. · The Journal of Organic Chemistry · 120

Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor

2010 · Timothy P. Heffron, Megan Berry, et al. · Bioorganic & Medicinal Chemistry Letters · 94

Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition

2012 · Brian S. Safina, Stewart Baker, et al. · Journal of Medicinal Chemistry · 68

Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase Delta

2012 · Jeremy M. Murray, Zachary K. Sweeney, et al. · Journal of Medicinal Chemistry · 66

Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K)

2016 · Georgette M. Castanedo, Nicole Blaquiere, et al. · Journal of Medicinal Chemistry · 65

Synthesis of tetrasubstituted thiophenes on solid-support using the Gewald reaction

2001 · Georgette M Castanedo, Daniel P Sutherlin · Tetrahedron Letters · 58

Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase

2018 · Nicole Blaquiere, Georgette M. Castanedo, et al. · Journal of Medicinal Chemistry · 57

Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf

2012 · Daniel P. Sutherlin, Stewart Baker, et al. · Bioorganic & Medicinal Chemistry Letters · 53

Corrigendum to “GDC-0449—A potent inhibitor of the hedgehog pathway” [Bioorg. Med. Chem. Lett. 19 (2009) 5576]

2009 · Kirk D. Robarge, Shirley A. Brunton, et al. · Bioorganic & Medicinal Chemistry Letters · 44

CDK2/cyclinA inhibitors: Targeting the cyclinA recruitment site with small molecules derived from peptide leads

2005 · Georgette Castanedo, Kevin Clark, et al. · Bioorganic & Medicinal Chemistry Letters · 42

Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors

2020 · Brendan T. Parr, Richard Pastor, et al. · ACS Medicinal Chemistry Letters · 32

Selective α4β7 Integrin Antagonists and Their Potential as Antiinflammatory Agents

2002 · Nathan J. P. Dubree, Dean R. Artis, et al. · Journal of Medicinal Chemistry · 32

Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase

2010 · Steven T. Staben, Timothy P. Heffron, et al. · Bioorganic & Medicinal Chemistry Letters · 31

Identification of GNE-293, a potent and selective PI3Kδ inhibitor: Navigating in vitro genotoxicity while improving potency and selectivity

2013 · Brian S. Safina, Zachary K. Sweeney, et al. · Bioorganic & Medicinal Chemistry Letters · 30

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Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Signal Peptidase

2020 · Homer Pantua, Elizabeth Skippington, et al. · mBio · 26

Introduction of Trifluoroethylamine as Amide Isostere by C–H Functionalization of Heteroarenes

2017 · Marie-Gabrielle Braun, Georgette Castanedo, et al. · Organic Letters · 25

Optimization of globomycin analogs as novel gram-negative antibiotics

2020 · Keira Garland, Homer Pantua, et al. · Bioorganic & Medicinal Chemistry Letters · 24

Solid-phase synthesis of dual α4β1/α4β7 integrin antagonists: two scaffolds with overlapping pharmacophores

2002 · Georgette M. Castanedo, Fredrick C. Sailes, et al. · Bioorganic & Medicinal Chemistry Letters · 17

Abstract DDT02-01: Discovery of GDC-0032: A beta-sparing PI3K inhibitor active against PIK3CA mutant tumors.

2013 · Alan G. Olivero, Timothy P. Heffron, et al. · Cancer Research · 15

Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway

2010 · Georgette M. Castanedo, Shumei Wang, et al. · Bioorganic & Medicinal Chemistry Letters · 14

Works count: 56

Citation count: 2,156

H-index: 22

I10-index: 30