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Cheng-Jung Lai
Observed names:
C J Lai,
C. Lai,
Chengjung Lai,
Cheng‐Jung Lai
Observed institutions:
Howard Hughes Medical Institute,
Harvard University,
Inserm,
University of Washington,
Taipei Veterans General Hospital,
Curis (United States),
Institut de Recherche en Cancérologie de Montpellier,
Dicerna Pharmaceuticals (United States),
Université Montpellier 1
show all 9
ORCID:
0000-0002-3321-8984
Observed ORCID:
0000-0002-3321-8984
OpenAlex ID:
A5018703558
A frizzled homolog functions in a vertebrate Wnt signaling pathway
1996
·
Julia Yang-Snyder
, Jeffrey R. Miller
, et al.
·
Current Biology
·
471
PDF
Discovery of 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDC-101) as a Potent Multi-Acting HDAC, EGFR, and HER2 Inhibitor for the Treatment of Cancer
2010
·
Xiong Cai
, Hai-Xiao Zhai
, et al.
·
Journal of Medicinal Chemistry
·
264
Cancer Network Disruption by a Single Molecule Inhibitor Targeting Both Histone Deacetylase Activity and Phosphatidylinositol 3-Kinase Signaling
2012
·
Changgeng Qian
, Cheng-Jung Lai
, et al.
·
Clinical Cancer Research
·
249
Specification of the Anteroposterior Neural Axis through Synergistic Interaction of the Wnt Signaling Cascade withnogginandfollistatin
1995
·
L.Lynn McGrew
, Cheng-Jung Lai
, et al.
·
Developmental Biology
·
224
CUDC-101, a Multitargeted Inhibitor of Histone Deacetylase, Epidermal Growth Factor Receptor, and Human Epidermal Growth Factor Receptor 2, Exerts Potent Anticancer Activity
2010
·
Cheng-Jung Lai
, Rudi Bao
, et al.
·
Cancer Research
·
218
PDF
Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis
1995
·
Stephen C. Ekker
, L. Lynn McGrew
, et al.
·
Development
·
208
Hepatitis B virus transcript produced by RNA splicing
1989
·
T S Su
, C J Lai
, et al.
·
Journal of Virology
·
128
PDF
CUDC-305, a Novel Synthetic HSP90 Inhibitor with Unique Pharmacologic Properties for Cancer Therapy
2009
·
Rudi Bao
, Cheng-Jung Lai
, et al.
·
Clinical Cancer Research
·
116
PDF
Specific Inhibition of Hepatic Lactate Dehydrogenase Reduces Oxalate Production in Mouse Models of Primary Hyperoxaluria
2018
·
Chengjung Lai
, Natalie Pursell
, et al.
·
Molecular Therapy
·
108
PDF
Inhibition of Glycolate Oxidase With Dicer-substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type 1
2016
·
Chaitali Dutta
, Nicole Avitahl-Curtis
, et al.
·
Molecular Therapy
·
81
Potential Advantages of CUDC-101, a Multitargeted HDAC, EGFR, and HER2 Inhibitor, in Treating Drug Resistance and Preventing Cancer Cell Migration and Invasion
2013
·
Jing Wang
, Natalie W. Pursell
, et al.
·
Molecular Cancer Therapeutics
·
81
Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage
1995
·
Cheng-Jung Lai
, Stephen C. Ekker
, et al.
·
Development
·
64
Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse Origin
2016
·
Shanthi Ganesh
, Martin L. Koser
, et al.
·
Molecular Cancer Therapeutics
·
62
Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non–small cell lung cancer
2009
·
Rudi Bao
, Cheng-Jung Lai
, et al.
·
Molecular Cancer Therapeutics
·
60
Dissecting Wnt signalling pathways and Wnf-sensitive developmental processes through transient misexpression analyses in embryos of Xenopus laevis
1993
·
Randall T. Moon
, Jan L. Christian
, et al.
·
Development
·
53
Expression of Wnt10a in the Central Nervous System of Developing Zebrafish
1993
·
Gregory M. Kelly
, Cheng-Jung Lai
, et al.
·
Developmental Biology
·
45
Inhibition of Glycogen Synthase II with RNAi Prevents Liver Injury in Mouse Models of Glycogen Storage Diseases
2018
·
Natalie Pursell
, Jessica Gierut
, et al.
·
Molecular Therapy
·
41
PDF
Therapeutic RNA interference: A novel approach to the treatment of primary hyperoxaluria
2021
·
Thomas A. Forbes
, Bob D. Brown
, et al.
·
British Journal of Clinical Pharmacology
·
33
TGF‐β signaling potentiates differentiation of embryonic stem cells to Pdx‐1 expressing endodermal cells
2005
·
Nobuaki Shiraki
, Cheng‐Jung Lai
, et al.
·
Genes to Cells
·
27
β-Catenin mRNA Silencing and MEK Inhibition Display Synergistic Efficacy in Preclinical Tumor Models
2017
·
Shanthi Ganesh
, Xue Shui
, et al.
·
Molecular Cancer Therapeutics
·
21
A First-In-Man Phase 1 Study Of CUDC-907, a First-In-Class Chemically-Designed Dual Inhibitor Of PI3K and HDAC In Patients With Refractory Or Relapsed Lymphoma and Multiple Myeloma
2013
·
Anas Younes
, Ian W. Flinn
, et al.
·
Blood
·
7
Abstract 3744: Antitumor activity of CUDC-907, a dual PI3K and HDAC inhibitor, in hematological cancer models
2012
·
Bao Rudi
, Dagong Wang
, et al.
·
Cancer Research
·
7
590 Final Results of a Phase Ib Study of CUDC-101, a Multitargeted Inhibitor of EGFR, HER2, and HDAC, in Patients with Advanced Head and Neck, Gastric, Breast, Liver, and Non-small Cell Lung Cancer
2012
·
M. Voi
, S. Fu
, et al.
·
European Journal of Cancer
·
5
siRNA Therapeutics to Treat Liver Disorders
2017
·
Chengjung Lai
, Cristina Martin-Higueras
, et al.
·
Springer eBooks
·
3
CUDC-907, a Dual HDAC and PI3K Inhibitor, Potentially Targets Cancer Cells and The Microenvironment In Hematological Malignancies
2013
·
Jing Wang
, Natalie Pursell
, et al.
·
Blood
·
3
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Works count:
55
Citation count:
2,582
H-index:
20
I10-index:
20
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